Early Phase 1 Completed N=90 Health Services Research

Prevalence of Lidocaine Ineffectiveness in Adults With and Without ADHD

Attention Deficit Hyperactivity Disorder · PMS

Source: ClinicalTrials.gov NCT03676725 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jul 2021

Primary outcomePrimary: Number of Subjects With Lidocaine Ineffectiveness — 11; 9; 16; 5 Participants — p=0.017

Summary

This work will assess the prevalence in the general population of the ineffectiveness of the anesthetic Lidocaine compared to males with ADHD and females with ADHD with or without PMS.

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Subjects With Lidocaine Ineffectiveness	11; 9; 16; 5; 15; 3	0.017 sig

Eligibility Criteria

Inclusion Criteria

Exclusion Criteria for both arms:

(1) known adverse reactions to lidocaine; (2) ADHD, ADD, and other inattention disorders; (3) epilepsy, IQ <80, severe head trauma, birth weight <2270 grams, and severe autism; (4) treatment currently with potassium or potassium-elevating drugs such as renin-angiotensin-aldosterone blockers; (5) generalized anxiety disorders (but dental-specific anxiety will not be an exclusion because many of these individuals may be ones with anxiety because of painful dental experiences with lidocaine ineffectiveness); (6) mouth sores; (7) Ehlers Danlos syndrome, (8) red hair, and (9) current pregnancy.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03676725). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.