N/A
N=31
The Relationship Between Autobiographical Memory and Motivation
Psychosis
Bottom Line
View on ClinicalTrials.gov: NCT03677635 ↗Enrolled (actual)
31
Serious AEs
0.0%
Results posted
Jul 2025
Primary outcome: Primary: Post-Intervention Motivation Score — 81.01; 72.89 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Guided Autobiographical Memory Recall (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- King's College London
- Primary completion
- Mar 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Post-Intervention Motivation Score |
81.01; 72.89 | — |
| SECONDARY Post-Intervention Anticipatory Pleasure |
84.35; 86.58 | — |
Summary
People with a diagnosis of psychosis often experience low motivation and pleasure when thinking about doing future activities. This leads, quite understandably, to doing fewer activities they used to enjoy and not taking up opportunities to do new activities. One model suggests that this may be partly due to difficulties using memories of previous events to help boost motivation and anticipation before a future activity. Research shows that people with psychosis may recall previous events in less detail. These memories therefore may not be as helpful as they could be for motivation. This study will investigate this by asking people with experience of psychosis and low motivation who are seen by a care team in South London and Maudsley NHS Trust to attend two research sessions. In the first session the participants will be asked to recall memories of events from their lives and the researcher will assess how detailed the memories are and how much the participant refers to the past and future. Alongside this task the participants will also be asked to complete measures of symptoms such as low pleasure and motivation as well as a measure of depression. These will be used to find out if the detail and specificity of the memories are related to these symptoms in people with psychosis. The second half of the study will then investigate whether additional prompts to support positive memory retrieval can increase the specificity of this and subsequently improve mood, motivation and self-belief. Participants will be randomised to one of two groups. The clinical group will be guided through their memory recall using prompts and a control group will be asked to recall positive memories without prompts. If the investigators show that supporting memory recall is beneficial then memories for past events may be an important target for future therapies.
Eligibility Criteria
Inclusion Criteria
- A diagnosis of non-affective psychosis (as determined by medical records).
- Above 18yrs old.
- A score of at least 18 on the Clinical Assessment Interview for Negative Symptoms.
- A sufficient command of the English language to engage with the research materials
Exclusion Criteria
- Lack of capacity to provide informed consent.
- Primary diagnosis of intellectual disability, head injury, substance misuse or known organic cause of psychosis
Data sourced from ClinicalTrials.gov (NCT03677635). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.