N/A
N=19
Visualizing Vascular Mechanisms of Salt Sensitivity
Obesity · Cardiovascular Risk Factor · Salt; Excess
Bottom Line
View on ClinicalTrials.gov: NCT03696433 ↗Enrolled (actual)
19
Serious AEs
0.0%
Results posted
Jan 2025
Primary outcome: Primary: Mean Arterial Blood Pressure Following High-salt Diet and Low-salt Diet — 83.3; 89.5 mmHg
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Low-salt diet (Dietary_supplement); High-salt diet (Dietary_supplement)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Vanderbilt University Medical Center
- Primary completion
- Nov 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Arterial Blood Pressure Following High-salt Diet and Low-salt Diet |
83.3; 89.5 | — |
Summary
This study aims to assess the salt sensitive blood pressure response to dietary salt load compared with radiological markers of salt handling.
Eligibility Criteria
Inclusion Criteria
- Identification as black race
- Age between 18 and 55 years
- Body mass index between 25 and <35 kg/m2
- Normotensive or pre-hypertensive
- Willing to adhere to study diets
- Able to provide informed consent and communicate with study personnel
Exclusion Criteria
- Prevalent cardiovascular disease or use of medications for cardiovascular disease
- Current or prior history of hypertension or use of blood pressure lowering medications
- Current or prior history of diabetes mellitus or use of anti-diabetic medications
- Prevalent renal disease (eGFR < 60 ml/min/1.73m2), abnormal serum sodium or potassium
- Current or prior smoker
- Current pregnancy, or use of hormone replacement therapy or oral contraceptive
- Current steroid use
- Contraindications to MRI
- Active infection or open wounds on the top of the feet or hands
Data sourced from ClinicalTrials.gov (NCT03696433). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.