N/A
Completed N=21
Low Intensity Focused Ultrasound for Learning and Memory and Emotion Regulation
Brain Diseases · Memory Disorders · Learning Disabilities · Mild Cognitive Impairment
Source: ClinicalTrials.gov NCT03717922 ↗
Enrolled (actual)
21
Serious AEs
0.0%
Results posted
Mar 2024
Primary outcomePrimary: Rey Auditory Verbal Learning Task — 50.00; 50.29; 47.59; 47.88 Words Recalled
Summary
The goal of this clinical trial is to investigate the impact of low intensity focused ultrasound pulsation (LIFUP) to two different brain regions, the amygdala and entorhinal cortex, in older adults. The main questions it aims to answer are:
1. Will LIFUP change brain activity in the targeted regions?
2. Will LIFUP to the amygdala have an impact on anxiety and emotion regulation?
3. Will LIFUP to the entorhinal cortex have an impact on memory performance?
Participants will complete two in-person visits including neuropsychological testing, MRI of the brain, and LIFUP to the brain.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Rey Auditory Verbal Learning Task |
50.00; 50.29; 47.59; 47.88; 10.18; 10.06 | — |
| PRIMARY State Trait Anxiety Inventory - State (STAIS) |
25.81; 30.69; 29.25; 30.63 | — |
| PRIMARY Average Perfusion in Regions Of Interest |
15.75; 6.72; 7.07; 19.52 | — |
| SECONDARY Emotional Reactivity Task |
2.24; 2.20; 2.14; 3.02; -0.10; -0.18 | — |
| SECONDARY Brief Visuospatial Memory Test |
9.63; 10.50; 8.56; 8.63 | — |
Eligibility Criteria
Inclusion Criteria
- Must be right handed
- English must be the dominant language
Exclusion Criteria
- contraindications for MRI (e.g. metal implants, pregnancy)
- history of head injury sufficient to warrant medical attention
- history of alcohol abuse or dependence
- history of substance abuse or dependence
- history of major psychiatric illness requiring treatment
- history of cancer or other neoplastic syndromes
- history of major neurologic illness (e.g. epilepsy).
Data sourced from ClinicalTrials.gov (NCT03717922). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.