N/A
N=235
Understanding the Post-Surgical Non-Small Cell Lung Cancer Patient's Symptom Experience
Fatigue · Self Efficacy · Quality of Life · Physical Activity · Lung Cancer
Bottom Line
View on ClinicalTrials.gov: NCT03724331 ↗Enrolled (actual)
235
Serious AEs
0.0%
Results posted
Feb 2026
Primary outcome: Primary: Cancer-related Fatigue Severity Using The Brief Fatigue Inventory. — 0.56; 4.19; 4.93 Scores on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Light Physical Activity 1 (Behavioral); Light Physical Activity 2 (Behavioral); Support Education Activity (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Nebraska
- Primary completion
- Nov 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Cancer-related Fatigue Severity Using The Brief Fatigue Inventory. |
0.56; 4.19; 4.93 | — |
| PRIMARY Cancer-Related Fatigue Fatigability as Assessed Using the 6 Minute Walk Test. |
389; 312; 300 | — |
| SECONDARY Other Symptoms Severity |
0.81; 1.57; 1.93 | — |
| SECONDARY Perceived Self-Efficacy for Fatigue Self-Management |
9.39; 6.31; 5.3 | — |
| SECONDARY Self-Efficacy for Walking Duration |
7.99; 5.15; 4.59 | — |
| SECONDARY Activities-Specific Balance Confidence |
9.1; 8; 7.54 | — |
| SECONDARY Steps Per Day |
3939; 3620; 2802 | — |
| SECONDARY Functional Status Performance |
45.97; 39.51; 35.57 | — |
| SECONDARY Quality of Life as Assessed Using the Quality of Life Index |
24.98; 23.61; 21.92 | — |
Summary
Among 13 core symptoms across 3,106 breast, colorectal, prostate, and lung cancer patients, persons with lung cancer were the most symptomatic, with moderate to severe fatigue being reported with the greatest prevalence. This is a proposed randomized controlled trial of a novel rehabilitative intervention for persons with non-small cell lung cancer after surgery that promotes self-management of cancer-related fatigue (CRF) and is practical, portable, low cost, and safe. The results of the study will provide a novel exercise intervention, and its optimal timing, that helps a vulnerable population by reducing CRF severity and fatigability and is applicable to nearly all post-thoracotomy lung cancer patients.
Eligibility Criteria
Inclusion Criteria
- Women and men
- At least 18 years of age (Michigan) and 19 years of age in (Nebraska)
- With suspected non-small cell lung cancer to be confirmed after surgery
- Karnofsky Performance Status score of at least 70%
- Thoracic surgeon approval pre- and post-surgery
- Medically stable comorbid conditions allowing for non-small cell lung cancer surgery clearance
- Has phone access capability
- Able to speak and write English
- Able to hear and speak for phone interviews
- Owns a television
- Lives within 2 hours driving distance of recruitment site
Exclusion Criteria
- Severe impairment of sight, hearing, speaking
- Active treatment for malignancy within past 3 months (other than non-melanoma skin cancer or long-term hormonal treatment for common cancers such as breast and prostate if disease is stable
- Weight greater than 330 pounds
- History of photosensitive seizures
- Any condition or disorder that would impede safe participation as directed
- Plans to relocate outside the area during the study period or unable to fully participate
Data sourced from ClinicalTrials.gov (NCT03724331). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.