Study of Avelumab-M3814 Combinations

Inclusion Criteria

• Part A and Part FE (M3814 + avelumab): Participants had histologically or cytologically proven advanced or metastatic solid tumors for which no standard therapy exists, standard therapy has failed, or participants are intolerant to or have rejected established therapy known to provide clinical benefit for their condition
• Part B (M3814 + Radiotherapy [RT] + avelumab): histologically or cytologically proven advanced or metastatic solid tumors for which no standard therapy exists, standard therapy has failed, or participants are intolerant to or have rejected established therapy known to provide benefit for their condition and are amenable to receive RT
• Part A, B and FE: Measurable or evaluable disease according to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v 1.1)
• Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 to 1 at study entry
• Part A, B and FE: Female participants of childbearing potential should be willing to use a highly effective contraceptive method
• Part A, B and FE: Male participants should agree to refrain from donating sperm plus, either: abstain from any activity that allows for exposure to ejaculate
• Use an adequate method of contraception starting with the first dose of study therapy through 90 days after the last dose of study therapy
• Part A, B and FE: Be willing to provide informed consent for the trial
• Other protocol defined inclusion criteria could apply

Exclusion Criteria

• Participants who had received prior chemotherapy, hormonal anticancer therapy with the exception of luteinizing hormone-releasing hormone analogs, biologic therapy, or any other anticancer therapy within 28 days of the first dose of study treatments (6 weeks for nitrosoureas or mitomycin C)
• Participants who had undergone major surgery for any reason, except diagnostic biopsy, within 4 weeks of the study intervention and/or has not fully recovered from the surgery within 4 weeks of the study intervention
• Participants with evidence of active or history of autoimmune disease that might deteriorate when receiving an immune-stimulatory agent
• Participants with brain metastases, except those meeting the following criteria: a) brain metastases that have been treated locally and are clinically stable for greater than or equal to (>=) 4 weeks prior to randomization b) no ongoing neurological symptoms that are related to the brain localization of the disease (sequelae that are a consequence of the treatment of the brain metastases are acceptable) c) participants must be either off steroids or on a stable or decreasing dose of less than ( =) 3 irAEs that did not respond to steroid rescue; or neurologic irAE with significant clinical sequelae
• Participants with irAE requiring hormone replacement therapy (e.g., thyroxine, insulin, or physiologic dose of corticosteroid replacement therapy for adrenal or pituitary insufficiency) may participate as long as the endocrinopathy is well controlled and the participant is not otherwise symptomatic from hormone insufficiency
• Physiologic corticosteroid dose is defined as = 30% of bone marrow reserve or prior bone marrow/stem cell transplantation within 5 years before study start
• If participant hepatic metastatic lesion is selected to be irradiated: - the non-tumor liver volume = 8
• Other protocol defined exclusion criteria could apply