N/A
N=8
Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy
Primary Progressive Aphasia · PPA
Bottom Line
View on ClinicalTrials.gov: NCT03728582 ↗Enrolled (actual)
8
Serious AEs
0.0%
Results posted
Apr 2023
Primary outcome: Primary: Change in Accuracy of Naming Trained Verbs (0 to 15, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery (OANB) — 2.3; 2.05 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Active tDCS plus Speech-Language Therapy (Device); Sham tDCS plus Speech-Language Therapy (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Johns Hopkins University
- Primary completion
- Mar 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Accuracy of Naming Trained Verbs (0 to 15, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery (OANB) |
2.3; 2.05 | — |
| SECONDARY Change in Accuracy of Naming Untrained Verbs (0 to 85, Higher Scores Reflect Better Naming Abilities) and Nouns (0 to 162, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery |
5.27; -0.408 | — |
| SECONDARY Change in Accuracy of Naming Trained Verbs (0 to 15, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery |
0.48; 1.0 | — |
| SECONDARY Change in Accuracy of Naming Untrained Verbs (0 to 85, Higher Scores Reflect Better Naming Abilities) and Untrained Nouns (0 to 162, Higher Scores Reflect Better Naming Abilities) as Assessed by Object and Action Naming Battery |
4.25; -8.84 | — |
| SECONDARY Change in Functional Communication Skills as Assessed by the Functional Assessment of Communication Skills for Adults (ASHA FACS) |
0.145; -0.59 | — |
| SECONDARY Change in Functional Communication Skills as Assessed by the Functional Assessment of Communication Skills for Adults (ASHA FACS) |
0.145; -0.59 | — |
Summary
People with Primary Progressive Aphasia (PPA) are is a debilitating disorder characterized by the gradual loss of language functioning, even though cognitive functioning is relatively well preserved until the advanced stages of the disease. There are very few evidence-based treatment options available. This study investigates the behavioral and neural effects of multiple consecutive tDCS sessions paired with language therapy targeting verbs in sentences with individuals with PPA.
Eligibility Criteria
Inclusion Criteria
- Diagnosis of PPA, based on the PPA criteria and presence of naming deficits
- Capable of giving informed consent or indicating another to provide informed consent
- 18 years of age to 100 years of age..
Exclusion Criteria
- Did not speak English before the age of five
- Less than 10 years of education
- Severe naming deficits
- Significant history of drug or alcohol abuse
- History of psychiatric or neurological problems affecting the brain (besides PPA)
- Has experienced seizures during the previous 12 months
- History of brain surgery or any metal in the head
- Uncorrected visual loss or hearing loss by self-report
- Use of medications that lower the seizure threshold (e.g., methylphenidate) or use of N-Methyl-D-aspartate (NMDA) receptor antagonists (e.g., memantine)
- Scalp sensitivity (per participant report)
Data sourced from ClinicalTrials.gov (NCT03728582). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.