N/A Completed N=38 Randomized Double-blind Supportive Care

Brain Connections and Blood Pressure

Hypertension · Mild Cognitive Impairment

Source: ClinicalTrials.gov NCT03736434 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Nov 2024

Primary outcomePrimary: Change in Resting State Network

Summary

This pilot randomized controlled study evaluates Mindfulness and DASH Diet resting state network and blood pressure in 36 (n=12 intervention; n=12 attention control; n = 12 control) Black and African American older adults with early Alzheimer's disease and related dementia disorders and hypertension.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Resting State Network	—	—
PRIMARY Change in Systolic Blood Pressure	-10.4; -3.2; -13.8	—
PRIMARY Change in Diastolic Blood Pressure	-4.1; -3.4; -5.7	—
SECONDARY Dietary Approaches to Stop Hypertension Questionnaire (DASH-Q) Change	-1.6; 0.2; -6	—
SECONDARY Cognitive and Affective Mindfulness Scale Change	-3.1; -2.1; 3.9	—
SECONDARY Perceived Stress Scale Change	1.2; 0.8; -5.9	—

Eligibility Criteria

Inclusion Criteria

Diagnosis of hypertension with or without medication use
Diagnosis of Alzheimer's disease or related dementia disorder or, if no formal diagnosis of Alzheimer's disease, then a Self-Assessment Gerocognitive Evaluation score 17-10 or a Montreal Cognitive Assessment Screen 25-19

Exclusion Criteria

Unable to understand spoken English
Expect to move out of the area within six months
fMRI imaging contraindicated (history of shrapnel, metal in the body, heart pacemaker, heart defibrillator, metal in the eye, gunshot wound, or some types of metal elsewhere within the body such as certain surgical clips for aneurysms in the head, heart valve prostheses, electrodes, and some other implanted devices) or claustrophobia. However, the participant can be included in the study without fMRI.
Self-reported history of a stroke
<6 on the Brief Assessment of Understanding of the Study

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03736434). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.