N/A
Completed N=163
Behavioral Memory Modulation in Nicotine Addiction
Source: ClinicalTrials.gov NCT03744559 ↗Enrolled (actual)
163
Serious AEs
0.0%
Results posted
Dec 2024
Primary outcomePrimary: Mean Craving Questionnaire Score, Response to the Novel Cue — 3.43; 3.73; 2.55; 2.88 score on a scale, average of 4 responses
Summary
The purpose of the study is to see if a behavioral intervention known as retrieval-extinction training (RET) might affect craving in response to nicotine cues (e.g., pictures, videos and objects) and smoking behavior in men and women who smoke cigarettes.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Craving Questionnaire Score, Response to the Novel Cue |
3.43; 3.73; 2.55; 2.88; 2.40; 2.59 | — |
| PRIMARY Mean Cigarettes Smoked Per Day |
9.4; 10.1; 7.2; 6.7; 7.5; 8.2 | — |
| SECONDARY Percentage of Smoking Days |
98.5; 98.1; 72.5; 70.2; 76.1; 74.7 | — |
| SECONDARY Mean Mood-Craving Response to the Novel Cue |
62.1; 69.5; 38.1; 46.5; 32.3; 33.5 | — |
Eligibility Criteria
Inclusion Criteria
- Healthy men and women, ages 25 to 65, who have smoked at least 10 cigarettes per day for at least 3 years.
- Participants must live within a 50-mile radius of the research facility and have reliable transportation.
- Participants must be willing to abstain from smoking starting the night before the baseline visit, and starting the night before visit 1 and remain abstinent for four consecutive days.
- Participants must agree to forego any other medication or behavioral treatment for smoking cessation while enrolled in the study (with the exception of the SC Quitline).
Exclusion Criteria
- Participants who are dependent on substances other than nicotine.
- Women who are pregnant during the clinical assessment session or either of the fMRI sessions. These participants must agree to notify the study staff if they become pregnant during the study.
Data sourced from ClinicalTrials.gov (NCT03744559). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.