Phase 2
Completed N=65
A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Moderate to Severe Atopic Dermatitis
Source: ClinicalTrials.gov NCT03747575 ↗Enrolled (actual)
65
Serious AEs
1.5%
Results posted
May 2023
Primary outcomePrimary: Percent Change of Total Eczema Area and Severity Index (EASI) Score — -51.47; -58.24 Percentage
Summary
This study will assess the efficacy and safety of MSTT1041A (astegolimab) in participants with moderate to severe atopic dermatitis (AD). The study consists of a screening period, a 16-week treatment period, and an 8-week follow-up period.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percent Change of Total Eczema Area and Severity Index (EASI) Score |
-51.47; -58.24 | — |
| SECONDARY Proportion of Participants Who Achieve Investigator's Global Assessment (IGA) Response of 0 or 1 |
15.2; 6.3 | — |
| SECONDARY Proportion of Participants Who Achieve >/=75% Reduction From Baseline in Eczema Area and Severity Index (EASI-75) Score |
27.3; 18.8 | — |
| SECONDARY Percent Change in Pruritus as Assessed by a Numeric Rating Scale (NRS) |
-31.22; -39.43 | — |
| SECONDARY Percent Change in Body Surface Area (BSA) With Atopic Dermatitis (AD) Involvement |
-42.23; -38.87 | — |
| SECONDARY Percent Change in Disease Severity as Assessed by SCORing Atopic Dermatitis (SCORAD) |
-35.45; -39.50 | — |
| SECONDARY Percentage of Participants With Adverse Events (AE) |
14; 18 | — |
| SECONDARY Serum Concentrations of MSTT1041A |
NA; 42.6; 37.6; 36.6; 40.1; 38.2 | — |
| SECONDARY Incidence of Treatment-Emergent Anti-Drug Antibodies (ADAs) |
1; 0 | — |
Eligibility Criteria
Inclusion criteria
- Ability to comply with the study protocol
- Chronic AD that has been present for at least 3 years before the screening visit
- Documented recent history (within 6 months before the screening visit) of inadequate response to treatment with topical medications (medications or treatments applied directly to part of the body) or for whom topical treatments are otherwise medically inadvisable
Exclusion criteria
- Prior treatment with MSTT1041A
- Treatment with any investigational therapy (with the exception of biologics) within 8 weeks or within 5 half-lives whichever is longer, before screening
- Treatment with any cell-depleting agents within 6 months before screening, or until lymphocyte count returns to normal, whichever is longer
- Treatment with other biologics within 3 months or 5 half-lives before screening, whichever is longer
- Comorbid conditions that may interfere with evaluation of investigational medicinal product
- History or evidence of substance abuse that would pose a risk to participant safety, interfere with the conduct of the study, have an impact on the study results, or affect the participant's ability to participate in the study
- History of anaphylaxis, hypersensitivity to a biologic agent, or known hypersensitivity to any component of the MSTT1041A or placebo injection
- Planned surgical intervention during the course of the study
- Pregnant or breastfeeding, or intending to become pregnant during the study
- Participant who is a member of the investigational team or his/her immediate family
Data sourced from ClinicalTrials.gov (NCT03747575). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.