Early Phase 1
N=79
Perceptual-motor Interaction to Improve Bimanual Coordination After Stroke
Stroke
Bottom Line
View on ClinicalTrials.gov: NCT03755076 ↗Enrolled (actual)
79
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcome: Primary: Maximum Cross-correlation Coefficient — 0.989; 0.945; 0.995; 0.996 cross-correlation coefficient — p=<0.001
Study Design & Population
- Study type
- Interventional
- Phase
- Early Phase 1
- Interventions
- Perceptual cuing (Behavioral)
- Age
- Adult, Older Adult · 21+ yrs
- Sex
- All
- Sponsor
- Albert Einstein Healthcare Network
- Primary completion
- Jan 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Maximum Cross-correlation Coefficient |
0.989; 0.945; 0.995; 0.996; 0.985; 0.951 | <0.001 sig |
| PRIMARY Between Hands Time-lag |
19.57; 72.75; 0.35; 1.55; 15.92; 51.51 | <0.001 sig |
Summary
Significant difficulty in incorporating the weaker arm in daily activities after stroke is, in part, driven by difficulty in engaging both arms interactively in a coordinated manner.
The current study aims to determine the nature of bimanual coordination deficits after stroke and takes initial steps to test a novel theory-driven approach to improve interactive bimanual coordination in patients with stroke. This project will advance stroke rehabilitation by identifying novel, scientifically-based strategies to improve the engagement of the weaker arm in coordinated and interactive bimanual actions of daily life, thus improving quality of life in individuals after stroke.
Eligibility Criteria
Inclusion Criteria
- Clinical diagnosis of unilateral stroke
- ability to reach along a diagonal direction at least 80% of their arm length while fully supported on a frictionless surface and trunk constrained.
- Mini-mental scale score > 26, OR s score of 4 or above on auditory verbal comprehension part of the Western Aphasia Battery to ensure intact comprehension and following commands.
(e) no evidence of hemispatial neglect tested by a line bisection test.
Exclusion Criteria
- bilateral stroke,
- complete paralyses,
- basal ganglia/cerebellar stroke,
- pain or stiffness in upper extremity that will interfere with the task or inability to follow task instructions.
Data sourced from ClinicalTrials.gov (NCT03755076). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.