Early Phase 1 Completed N=79 Treatment

Perceptual-motor Interaction to Improve Bimanual Coordination After Stroke

Source: ClinicalTrials.gov NCT03755076 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2025

Primary outcomePrimary: Maximum Cross-correlation Coefficient — 0.989; 0.945; 0.995; 0.996 cross-correlation coefficient — p=<0.001

Summary

Significant difficulty in incorporating the weaker arm in daily activities after stroke is, in part, driven by difficulty in engaging both arms interactively in a coordinated manner. The current study aims to determine the nature of bimanual coordination deficits after stroke and takes initial steps to test a novel theory-driven approach to improve interactive bimanual coordination in patients with stroke. This project will advance stroke rehabilitation by identifying novel, scientifically-based strategies to improve the engagement of the weaker arm in coordinated and interactive bimanual actions of daily life, thus improving quality of life in individuals after stroke.

Outcome Measures

Outcome	Result	p-value
PRIMARY Maximum Cross-correlation Coefficient	0.989; 0.945; 0.995; 0.996; 0.985; 0.951	<0.001 sig
PRIMARY Between Hands Time-lag	19.57; 72.75; 0.35; 1.55; 15.92; 51.51	<0.001 sig

Eligibility Criteria

Inclusion Criteria

Clinical diagnosis of unilateral stroke
ability to reach along a diagonal direction at least 80% of their arm length while fully supported on a frictionless surface and trunk constrained.
Mini-mental scale score > 26, OR s score of 4 or above on auditory verbal comprehension part of the Western Aphasia Battery to ensure intact comprehension and following commands.

(e) no evidence of hemispatial neglect tested by a line bisection test.

Exclusion Criteria

bilateral stroke,
complete paralyses,
basal ganglia/cerebellar stroke,
pain or stiffness in upper extremity that will interfere with the task or inability to follow task instructions.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03755076). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.