N/A
Completed N=55
Moderate-Intensity Exercise Versus High-Intensity Interval Training to Recover Walking Post-Stroke
Source: ClinicalTrials.gov NCT03760016 ↗Enrolled (actual)
55
Serious AEs
7.3%
Results posted
Jul 2023
Primary outcomePrimary: Six-Minute Walk Test Distance — 27; 12 meters
Summary
The objective of this study is to determine the optimal training intensity and the minimum training duration needed to maximize immediate improvements in walking capacity in chronic stroke. A single-blind, phase II, 3-site randomized controlled trial has been planned. Fifty persons >6 months post stroke will randomize to either moderate-intensity aerobic locomotor training or high-intensity interval locomotor training; each for 45 minutes, 3x/week for up to 36 total sessions over approximately 12 weeks. Clinical measures of walking function, aerobic fitness, daily walking activity and quality of life will be assessed at baseline (PRE) and after 4, 8 and 12 weeks of training (POST-4WK, POST-8WK, POST-12WK).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Six-Minute Walk Test Distance |
71; 27 | — |
| SECONDARY Comfortable Gait Speed |
0.19; 0.06 | — |
| SECONDARY Fast Gait Speed |
0.28; 0.09 | — |
| SECONDARY Aerobic Fitness |
1.9; 1.4 | — |
| SECONDARY PROMIS-Fatigue Scale |
-1.1; -0.1 | — |
Eligibility Criteria
Inclusion Criteria
- Age 40-80 years at time of consenting
- Single stroke for which participant sought treatment, 6 months to 5 years prior to consent date
- Walking speed 2)
- Recent history ( 3 cumulative hours) during clinical or research therapy in the past year
Data sourced from ClinicalTrials.gov (NCT03760016). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.