Trial of Neoadjuvant and Adjuvant Nivolumab and BMS-813160 With or Without GVAX for Locally Advanced Pancreatic Ductal Adenocarcinomas.

Inclusion Criteria

• Age ≥18 years.
• Patients with histologically- or cytologically-proven, surgically unresectable, locally advanced pancreatic adenocarcinoma.
• If the patient does not have a diagnostic biopsy that is adequate for review at our institution, the patient must agree to a research core biopsy to be performed at Johns Hopkins.
• If the patient's available imaging is not adequate for review by our institution, the patient must agree to a repeat imaging to be performed at Johns Hopkins.
• ECOG performance status 0 or 1
• Life expectancy greater than 3 months.
• Able to swallow pills or capsules.
• Patient must have adequate organ function defined by the study-specified laboratory tests.
• Patients must be eligible to receive FOLFIRINOX-based chemotherapy.
• Patients must be willing to be treated with stereotactic body radiation therapy (SBRT) only at Johns Hopkins Hospital.
• Patients must be willing to undergo a core biopsy of the pancreatic cancer.
• Patients must be willing to undergo a biopsy of the pancreatic cancer if the patient is not deemed a surgical candidate during the pre-surgical evaluation.
• Must use acceptable form of birth control while on study.
• Ability to understand and willingness to sign a written informed consent document.

Exclusion Criteria

• Patients cannot have had any prior therapy for the locally advanced pancreatic adenocarcinoma.
• Have received any anti-neoplastic biologics, vaccines or hormonal treatment, including investigational drugs, within 28 days of the first dose of study.
• History of past treatment with immunotherapy agents prior to initial enrollment into this study (including, but not limited to: IL-2, interferon, anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, anti-OX-40, anti-CD40, anti-CTLA-4 or anti-CCR2/5 drugs).
• Have had prior organ or tissue allograft or allogeneic bone marrow transplantation, including corneal transplants.
• Is currently participating or has participated in a study of an investigational agent or using an investigational device for the treatment of cancer.
• Current use of immunosuppressive medications within 14 days prior to study medications.
• Have received any vaccine within 14 days prior to study medications.
• Receiving growth factors including, but not limited to, granulocyte-colony stimulating factor (G-CSF), GM-CSF, erythropoietin, within 14 days of the first dose of study medication.
• History of any autoimmune disease. Patients with thyroid disease will be allowed.
• Has a history of (non-infectious) pneumonitis or current pneumonitis.
• Has a pulse oximetry < 92% on room air.
• Requires the use of home oxygen.
• Patients with uncontrolled intercurrent illness including, but not limited to, myocardial infarction or stroke/transient ischemic attack within the past 6 months, uncontrolled infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• 12-lead electrocardiogram with QRS ≥ 120 msec, except right bundle branch block ; QTcF (QT corrected for heart rate using Fridericia's method) ≥ 480 msec, except right bundle branch block
• Has an active infection requiring systemic therapy.
• Infection with HIV or hepatitis B or C.
• Any concurrent malignancy other than non-melanoma skin cancer, non-invasive bladder cancer, early stage prostate cancer, or carcinoma in situ of the cervix.
• Current or recent (within 3 months of study treatment administration) gastrointestinal disease that could impact the absorption of study treatment.
• Any gastrointestinal surgery that is likely impact upon the absorption of study treatment.
• Inability to tolerate oral medication.
• Unable to have blood drawn.
• Have had surgery within 28 days of the first dose of study medication.
• Prior use of strong/moderate CYP3A4 inhibitors or inducers within 28 days of the first dose of BMS-813160.
• Prior use of Class I antiarrhythmi