Nanomedicine strategies show promise for targeting pancreatic ductal adenocarcinoma
Nanomedicine options for pancreatic cancer remain theoretical in current reviews
This narrative review surveys nanomedicine approaches for pancreatic ductal adenocarcinoma, including polymeric nanoparticles, small-molecul…
Current reviews suggest nanomedicine and other advanced therapies for pancreatic cancer are still theoretical concepts without proven clinic…
Narrative review on KMT2C alterations in gastrointestinal cancers and therapeutic implications
Genetic changes in gut cancers may open new treatment doors for patients
This narrative review synthesizes evidence on KMT2C alterations across gastrointestinal malignancies. It links KMT2C dysfunction to transcri…
A review of genetic changes in gastrointestinal cancers suggests new ways to treat tumors by targeting specific DNA repair weaknesses.
Case report and literature review on IgG4-related disease misdiagnosed as pancreatic cancer in a 70-year-old male
A 70-year-old man avoided unnecessary surgery after doctors found a treatable autoimmune condition
This case report and literature review examines a 70-year-old male patient with IgG4-related autoimmune pancreatitis initially suspected as …
A 70-year-old man with a pancreatic mass was found to have a treatable autoimmune disease, sparing him from unnecessary surgery.
Robot-assisted distal pancreatectomy reduces blood loss and conversions but increases operative time and cost
Robot Surgery Matches Laparoscopic for Pancreas Cancer Outcomes
This systematic review and meta-analysis of 15790 patients undergoing distal pancreatectomy found that robot-assisted distal pancreatectomy …
New data shows robot-assisted pancreas surgery matches standard laparoscopic methods in safety and cancer control, while cutting blood loss …
AI models improve diagnostic accuracy for pancreatic ductal adenocarcinoma compared to conventional methods
AI models improve pancreatic cancer diagnosis accuracy in large review
This systematic review and meta-analysis evaluated radiomics-based models derived from computed tomography, magnetic resonance imaging, posi…
A large review shows AI tools using scans can detect pancreatic cancer with higher accuracy than standard methods, offering hope for earlier…
RNK08954 shows unconfirmed responses in KRASG12D-mutant NSCLC and PDAC in Phase Ia trial
New drug shows promise for KRASG12D lung and pancreatic cancers
This phase Ia trial evaluated RNK08954 in 36 patients with KRASG12D-mutant non-small cell lung cancer or pancreatic ductal adenocarcinoma.
An early trial of RNK08954 shrank tumors in 58% of lung cancer patients with a specific KRAS mutation.
Narrative review outlines miRNA-based strategies and challenges in pancreatic ductal adenocarcinoma management
Tiny RNA tricks could help immunotherapy fight pancreatic cancer
This narrative review examines miRNA-based strategies within the context of pancreatic ductal adenocarcinoma treatment options available tod…
MicroRNAs may help immunotherapy work in hard-to-treat pancreatic cancer by reshaping the tumor environment.
Machine learning model predicted FOLFIRINOX dose modifications in pancreatic ductal adenocarcinoma cohort
Most patients on strong pancreatic cancer chemo needed a dose change
This cohort study included 514 patients with pancreatic ductal adenocarcinoma treated at UCSF oncology clinics.
Over 60% of patients with pancreatic cancer needed a dose adjustment during treatment with FOLFIRINOX at UCSF clinics.
Systematic review and meta-analysis of CLDN18.2 expression prevalence in pancreatic ductal adenocarcinoma
Half of Pancreatic Cancers May Have a Hidden Target for New Therapies
This systematic review and meta-analysis evaluated CLDN18.2 expression prevalence in 2,025 adult patients with pancreatic ductal adenocarcin…
A hidden doorway may exist inside many pancreatic tumors.
Narrative review reports Onca model performance on pancreatic cancer tasks versus other LLMs
New AI tool helps doctors find pancreatic cancer trials faster
This narrative review and model development report evaluates an open 9B dense language model, Onca, against four comparators for pancreatic …
A new AI tool helps doctors quickly match patients with pancreatic cancer trials using open data.
Narrative review on fructose metabolism in pancreatic ductal adenocarcinoma stress tolerance
Fructose Fuels Pancreatic Cancer Survival
This narrative review synthesizes evidence on fructose metabolism in pancreatic ductal adenocarcinoma.
Understanding how sugar and stress signals work together opens doors for new ways to starve these tumors.
SCOPE platform predicts outcomes for metastatic colorectal and pancreatic cancers using organoid screening
A Lab-Built Tumor Test May Predict If Cancer Drugs Will Work
This preclinical platform development study utilized a machine learning system integrating patient-derived organoids and clinical data to pr…
A platform called SCOPE uses tiny lab-grown copies of a patient's tumor to predict — before a large trial even starts — whether a cancer dru…
Research across Cancer
Related studies from across the Cancer family.
Guideline-based case report: neoadjuvant alectinib in ALK-rearranged stage IIIB lung cancer
One woman shows how alectinib shrinks lung cancer before surgery
This guideline-based case report describes a 57-year-old woman with ALK-rearranged stage IIIB lung cancer treated with neoadjuvant alectinib…
A single case shows alectinib shrinking lung cancer before surgery. This report offers hope for specific patients but needs more study.
FDA approves OPDIVO QVANTIG for multiple advanced cancer indications including renal cell carcinoma and melanoma
FDA approves subcutaneous nivolumab combination for multiple advanced cancers
This FDA approval document grants authorization for OPDIVO QVANTIG, a subcutaneous combination of nivolumab and hyaluronidase, for specified…
The FDA has approved a new subcutaneous form of nivolumab for several advanced cancers, offering a more convenient treatment option for elig…
Case report on ivonescimab for EGFR-TKI-resistant lung adenocarcinoma with pericardial effusion
One Drug Shrinks Lung Tumors When Others Stop Working
This is a case report and literature review of a 77-year-old female with EGFR-TKI-resistant advanced lung adenocarcinoma and malignant peric…
A 77-year-old woman with advanced lung cancer saw her tumors shrink and dangerous fluid around her heart disappear after trying a new drug c…
Case report and literature review on oxaliplatin and tegafur for AEG with intramural metastasis
A rare cancer spread inside the esophagus wall needs careful treatment plans for older adults
This case report and literature review examines a 77-year-old male with adenocarcinoma of the esophagogastric junction and esophageal intram…
A doctor reviewed a rare case where cancer spread inside the esophagus wall. This condition often means the disease is already in the body. …
Systematic review and meta-analysis of survival outcomes in HPV-independent versus HPV-associated cervical adenocarcinoma
One Type of Cervical Cancer Is Far More Dangerous Than Others
This systematic review and meta-analysis synthesized comparative studies on HPV-independent and HPV-associated cervical adenocarcinoma. It f…
A large new analysis reveals that women with HPV-negative cervical adenocarcinoma face nearly three times the risk of death compared to thos…
Meta-analysis shows neoadjuvant chemoradiation improves resection and survival outcomes for esophageal squamous cell carcinoma patients compared to chemotherapy alone
Adding radiation before surgery helps some esophageal cancer patients get better surgery results and live longer
This meta-analysis of 2,174 patients reveals that adding radiation to chemotherapy significantly boosts resection rates and survival for squ…
A large review found that adding radiation to chemotherapy before surgery helped remove more tumors in certain cancer types. This approach a…
TaTME shows lower conversion rates with similar short-term safety compared to LapTME for low rectal cancer
New surgical approach for rectal cancer cuts conversion rate
This randomized trial compared transanal total mesorectal excision with laparoscopic total mesorectal excision for patients with low rectal …
A new surgical technique for rectal cancer reduces the need to switch to open surgery, with similar complication rates.
Meta-analysis shows percutaneous irreversible electroporation plus immunotherapy improves outcomes in locally advanced pancreatic cancer
Adding immunotherapy to ablation therapy extends life for pancreatic cancer patients
This systematic review and meta-analysis evaluated percutaneous irreversible electroporation combined with immunotherapy versus irreversible…
Adding immune therapy to ablation therapy helps patients live longer with locally advanced pancreatic cancer without causing more side effec…
Retrospective analysis finds sarcopenia associated with shorter disease-free survival in pancreatic neuroendocrine tumor patients
Low muscle mass linked to shorter disease-free survival in pancreatic tumor patients
This retrospective cohort study included 86 patients who underwent curative-intent resection for pancreatic neuroendocrine tumors.
Low muscle mass before surgery was linked to shorter disease-free survival in patients with pancreatic neuroendocrine tumors, though this li…
H. pylori prevalence 34.3% in French Guiana; gastric adenocarcinoma found in 1.65%
One Third of Stomach Tests Show Hidden Bacteria Risk
A retrospective cohort study of 545 patients with H.
A new look at stomach biopsies shows one in three patients carry a hidden bacteria that can lead to serious disease.
Adjuvant chemotherapy improves overall survival in resectable stage I-III duodenal adenocarcinoma patients
After Surgery, This Extra Step May Extend Survival in Rare Cancer
This retrospective cohort study evaluated 98 patients with resectable stage I-III duodenal adenocarcinoma at two Chinese institutions.
After surgery for duodenal cancer, adding chemotherapy may nearly double survival time, but larger trials are still needed.
In a prospective cohort, periampullary tumor surgery affected quality of life and survival metrics
Life After Major Cancer Surgery Isn’t What We Thought
This prospective cohort study evaluated 111 patients undergoing pancreaticoduodenectomy for periampullary tumors at a University Medical Cen…
Imagine waking up after major cancer surgery.
Questions about Pancreatic Ductal Adenocarcinoma
What is the prevalence of CLDN18.2 expression in patients with pancreatic ductal adenocarcinoma?
About 52% of PDAC patients express CLDN18.2, but prevalence varies by testing method; 27% meet clinical trial positivity criteria.
Full answer →Can AI models improve diagnostic accuracy for pancreatic ductal adenocarcinoma compared to conventional methods?
Yes, AI models improve diagnostic accuracy for pancreatic ductal adenocarcinoma compared to conventional methods, with radiomics and machine learning showing high sensitivity and specificity.
Full answer →All Pancreatic Ductal Adenocarcinoma Articles
- Nanomedicine strategies show promise for targeting pancreatic ductal adenocarcinoma
- Narrative review on KMT2C alterations in gastrointestinal cancers and therapeutic implications
- Case report and literature review on IgG4-related disease misdiagnosed as pancreatic cancer in a 70-year-old male
- Robot-assisted distal pancreatectomy reduces blood loss and conversions but increases operative time and cost
- RNK08954 shows unconfirmed responses in KRASG12D-mutant NSCLC and PDAC in Phase Ia trial
- AI models improve diagnostic accuracy for pancreatic ductal adenocarcinoma compared to conventional methods
- Machine learning model predicted FOLFIRINOX dose modifications in pancreatic ductal adenocarcinoma cohort
- Narrative review outlines miRNA-based strategies and challenges in pancreatic ductal adenocarcinoma management
- Narrative review reports Onca model performance on pancreatic cancer tasks versus other LLMs
- Systematic review and meta-analysis of CLDN18.2 expression prevalence in pancreatic ductal adenocarcinoma
- Narrative review on fructose metabolism in pancreatic ductal adenocarcinoma stress tolerance
- PRISM EHR-based model identifies adults at high risk for pancreatic ductal adenocarcinoma in real-world setting
- Review describes Virtual Spectral Decomposition framework for cancer imaging analysis
- SCOPE platform predicts outcomes for metastatic colorectal and pancreatic cancers using organoid screening
- Gemcitabine exposure associated with higher TP53 and PI3K pathway alterations in pancreatic ductal adenocarcinoma tumors
- Review of Virtual Spectral Decomposition for pancreatic cancer detection on CT scans
- Review of CAR-T cell therapy for pancreatic ductal adenocarcinoma reports no specific outcomes or safety data
- Setidegrasib shows antitumor activity in advanced NSCLC and pancreatic cancer with p.G12D variants
- Epigenomic ctDNA profiling identifies PDAC subtypes and improves prognostication over tissue-based methods in metastatic disease
- Tumor-associated neutrophils regulate PDAC progression via TGF-β and CXCR2 pathways
- New-onset diabetes in adults over 50 associated with higher pancreatic cancer risk within 3 years