N/A
Completed N=50
Isokinetic Exercises in Patients With Multiple Sclerosis
Source: ClinicalTrials.gov NCT03779724 ↗Enrolled (actual)
50
Serious AEs
—
Results posted
Jul 2019
Primary outcomePrimary: Isokinetic Muscle Strength Test of the More and Less Affected Knees — 110.48; 141.05; 123.02; 127.83 Newton/meter
Summary
The investigators evaluated the effects of isokinetic muscle strengthening exercises of the quadriceps and hamstring on muscle strength, joint position sense, pain, kinesiophobia and quality of life in patients with multiple sclerosis.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Isokinetic Muscle Strength Test of the More and Less Affected Knees |
110.48; 141.05; 123.02; 127.83; 69.25; 85.87 | — |
| PRIMARY Joint Position Sense of the More and Less Affected Knees |
5.56; 4.39; 5.70; 5.03; 4.94; 4.38 | — |
| PRIMARY Tampa Scale of Kinesiophobia |
42.42; 40.57; 40.33; 40.33 | — |
| PRIMARY Multiple Sclerosis Quality of Life-54 Total Score, Physical and Emotional Composite Scores, and Pain Subscale Score |
52.20; 57.00; 61.38; 59.39; 50.79; 54.69 | — |
| PRIMARY Visual Analog Scale |
40.78; 36.68; 41.66; 42.14 | — |
Eligibility Criteria
Inclusion Criteria
- definite relapsing remitting MS and secondary progressive MS diagnosis
- mild and moderate MS determined by Kurtzke Expanded Disability Status Scale (EDSS) scores below 6.5
- a disease duration of more than one year.
Exclusion Criteria
- having an acute exacerbation within the last three months
- intravenous pulse steroid therapy in the last four weeks
- grade 3-4 spasticity according to the Modified Ashworth Scale
- severe vision impairment
- severe fatigue and depression
- past knee surgery
- other neurologic diseases
- systemic diseases
- pregnancy
- having received an exercise program within the last four weeks.
Data sourced from ClinicalTrials.gov (NCT03779724). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.