N/A
N=5
Analysis of Electrocorticographic Signals
Epilepsy
Bottom Line
View on ClinicalTrials.gov: NCT03785028 ↗Enrolled (actual)
5
Serious AEs
0.0%
Results posted
May 2024
Primary outcome: Primary: Qualitative Measure: Prioritization Cue-related Changes in the Neural Representation of Stimuli Reported as Binary for Prioritized and Unprioritized Item Decodability — 1; 1; 1; 0 group of all participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- working memory and attention (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Wisconsin, Madison
- Primary completion
- Feb 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Qualitative Measure: Prioritization Cue-related Changes in the Neural Representation of Stimuli Reported as Binary for Prioritized and Unprioritized Item Decodability |
1; 1; 1; 0; 0; 0 | — |
| PRIMARY Qualitative Measure: Working Memory Delay Period Phase-amplitude Coupling Reported as Direction (Increase/Decrease) for Region and Stimulus Type |
1; 1; 0; 0; 1; 1 | — |
| PRIMARY Experiment 3.b. Covert Spatial Attention-related Changes in Phase-amplitude Coupling |
— | — |
Summary
The objectives of this research are to understand how the brain can keep information in mind ("working memory"), and use this information to guide behavior. The two experiments that fall under this study will collect brain signals from epilepsy patients who are having surgery as part of their treatment. More specifically, these signals will be studied from the time while the patient is performing two cognitive tasks.The endpoints are publication of the results from each of the proposed experiments in peer-reviewed journals.
Eligibility Criteria
Inclusion Criteria
- Participants with implanted electrode arrays who are willing to participate and able to cooperate and follow research instructions will be recruited.
- Must be able to read
- Must be able to name objects
- Must be able to articulate thoughts with spoken language
Exclusion Criteria
- post-operative pain requiring narcotics
- repeated seizures clouding consciousness
- IQ of 85 and below
- post-operative subdural bleeding
- cerebral pathology affecting the cortical regions from which recordings are made
- women who are pregnant, or who think they may be pregnant
Data sourced from ClinicalTrials.gov (NCT03785028). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.