N/A
N=17
High Frequency Oscillation in Pediatric Epilepsy Surgery
Pediatric Epilepsy · Epilepsy Surgery · High Frequency Oscillation
Bottom Line
View on ClinicalTrials.gov: NCT03790280 ↗Enrolled (actual)
17
Serious AEs
0.0%
Results posted
Sep 2023
Primary outcome: Primary: Post-operative Seizure-free Rate — 4; 5; 4; 4 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- HFO analysis (Diagnostic_test)
- Age
- Pediatric, Adult · 0+ yrs
- Sex
- All
- Sponsor
- University of California, Los Angeles
- Primary completion
- Jul 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Post-operative Seizure-free Rate |
4; 5; 4; 4 | — |
| SECONDARY Post-operative Complication |
0; 0 | — |
Summary
High Frequency Oscillation (HFO) on ElectroCorticoGraphy (ECoG) has been identified as a new biomarker for epileptogenic tissue. The purpose of this study is to see if epilepsy surgery guided by the combination of HFO on ECoG and standard clinical practice can result in a greater likelihood of seizure freedom, versus standard clinical practice alone, without HFOs.
Eligibility Criteria
Inclusion Criteria
- Age 0-21 years
- Refractory focal epilepsy
- Planned resective epilepsy neurosurgery
- Includes intraoperative or extraoperative electrocorticography with grids
- Planned resective epilepsy surgery approved by institutional surgery board
Exclusion Criteria
- Subjects undergoing non-resective neurosurgery
- Does not include intraoperative or extraoperative electrocorticography with grids
- Planned resective surgery is a hemispherectomy/hemispherotomy
Data sourced from ClinicalTrials.gov (NCT03790280). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.