N/A N=16 Randomized Treatment

Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome · ARDS

Bottom Line

View on ClinicalTrials.gov: NCT03793842 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Oct 2023

Primary outcome: Primary: Mechanical Power — 1.87; -2.50 J/min — p=.002

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Usual care (Other); PEEP titration by EIT (Device)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Michigan
Primary completion: Jun 2022

Outcome Measures

Outcome	Result	p-value
PRIMARY Mechanical Power	1.87; -2.50	.002 sig
SECONDARY Change in Lung Inflammation as Measured by Physiologic Parameter: Partial Pressure of Arterial Oxygen/Fraction of Inspired Oxygen (P/F Ratio)	25.14; -0.89	0.2
SECONDARY Change in Lung Inflammation as Measured by Physiologic Parameter: Plateau Pressure	2.06; -2.48	0.006 sig
SECONDARY Lung Inflammation as Measured by Physiologic Parameter: Driving Pressure	1.34; -1.58	0.003 sig
SECONDARY Change in Lung Inflammation as Measured by Physiologic Parameter: Static Compliance	3.24; -4.6	0.008 sig
SECONDARY Partial Pressure of Arterial Oxygen (PaO2)	—	—
SECONDARY Dynamic Compliance (Cdyn)	—	—
SECONDARY Change in Compliance Over the Last 20% of Inspiration (C20/Dyn)	—	—
SECONDARY Ultrasound Surrogates of Lung Aeration	—	—

Summary

Doctors follow a standard ventilator management strategy when making adjustments to the breathing machine to optimize the amount of oxygen into the lungs. The purpose of this study is to assess whether the EIT (electrical impedance tomography) device can be an additional useful tool for ventilator management and identifying the ideal positive end-expiratory pressure (PEEP).

Eligibility Criteria

Inclusion Criteria

Endotracheal ventilation for 5 cm water for > 30 min.

ii. bilateral opacities not fully explained by effusions, lobar/lung collapse, or nodules iii. respiratory failure not fully explained by cardiac failure or fluid overload

-All criteria listed in (3) developed within 1 week of a known clinical insult or new or worsening respiratory symptoms

Exclusion Criteria

Lack of informed consent
Known pregnancy
Extracorporeal membrane oxygenation (ECMO) use
Severe chronic respiratory disease requiring home oxygen therapy or ventilation
Calculated BMI of greater than 50

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03793842). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.