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Home › Conditions › Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome

Subtypes of Acute Respiratory Distress Syndrome

Acute Lung Injury 4 Hyaline membrane disease 1 Neonatal respiratory distress syndrome 1 Preterm Infant Respiratory Distress 0

24 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Acute Respiratory Distress Syndrome

67 trials tracked for Acute Respiratory Distress Syndrome: 12 in phase 3 or 4 and 10 with published results. The most-cited published study has 1406 citations.

67Trials tracked
12Phase 3 & 4
0Recruiting
10With published results
Phase distribution
Phase 4 1 Phase 3 11 Phase 2 23 Phase 1 3 Other / NA 29
  1. Phase 3 Post-exposure Prophylaxis / Preemptive Therapy for SARS-Coronavirus-2 Completed · 1,406 cited
  2. Phase 3 Reevaluation Of Systemic Early Neuromuscular Blockade Completed · 876 cited
  3. Phase 3 Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial Completed · 813 cited
  4. Phase 3 Vitamin D to Improve Outcomes by Leveraging Early Treatment Completed · 301 cited
  5. Phase 3 Pre-exposure Prophylaxis for SARS-Coronavirus-2 Completed · 128 cited
  6. Phase 3 Comparison of Aerosol Delivery of Infasurf to Usual Care in Spontaneously Breathing RDS Patients Completed · 91 cited
Show 44 more trials
  1. Phase 3 Dornase Alfa for ARDS in Patients With Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Completed · 75 cited
  2. Phase 3 Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure Completed · 27 cited
  3. Phase 3 A Multi-center Trial to Determine if Curosurf® Reduces the Duration of Mechanical Ventilation in Very Preterm Infants Completed · 19 cited
  4. Phase 3 A Study to Test Whether Different Doses of Alteplase Help People With Severe Breathing Problems Because of COVID-19 Completed · 3 cited
  5. Phase 4 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed
  6. Phase 3 Nitric Oxide Administration for Acute Respiratory Distress Syndrome Completed
  7. Phase 2 Trial to Assess the Safety and Tolerability of Lucinactant for Inhalation in Premature Neonates Completed
  8. Phase 2 Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury Completed
  9. Phase 2 Fibrinolytic Therapy to Treat ARDS in the Setting of COVID-19 Infection Completed
  10. Phase 2 Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19) Completed
  11. Phase 2 Extracorporeal Membrane Oxygenation (ECMO) in Non-intubated Patients With Acute Respiratory Distress Syndrome (ARDS) Completed
  12. Phase 2 Losartan for Patients With COVID-19 Requiring Hospitalization Completed
  13. Phase 2 LIPS-B: Lung Injury Prevention Study With Budesonide and Beta Completed
  14. Phase 2 Tenecteplase in Patients With COVID-19 Completed
  15. Phase 2 LSALT Peptide vs. Placebo to Prevent ARDS and Acute Kidney Injury in Patients Infected With SARS-CoV-2 (COVID-19) Completed
  16. Phase 2 Efficacy and Safety of Itolizumab in COVID-19 Complications Completed
  17. Phase 2 The Safety and Efficacy of Lucinactant for Inhalation in Premature Neonates 26 to 32 Weeks Gestational Age Completed
  18. Phase 2 Safety, Tolerability and Preliminary Efficacy of FP-1201 in ALI and ARDS. Phase I/II Completed
  19. Phase 2 Double-blind, Randomized, Controlled Clinical Trial to Assess Efficacy of MSC in Patients With COVID-19 ARDS Completed
  20. Phase 2 A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19 Completed
  21. Phase 2 Losartan for Patients With COVID-19 Not Requiring Hospitalization Completed
  22. Phase 2 Use of UC-MSCs for COVID-19 Patients Completed
  23. Phase 2 Vadadustat for the Prevention and Treatment of Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Completed
  24. Phase 2 Mesenchymal Stromal Cells for the Treatment of SARS-CoV-2 Induced Acute Respiratory Failure (COVID-19 Disease) Completed
  25. Phase 2 LIPS-A: Lung Injury Prevention Study With Aspirin Completed
  26. Phase 2 Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure Completed
  27. Phase 2 A Phase II Randomized Trial of Fish Oil in Patients With Acute Lung Injury (ALI) Completed
  28. Phase 2 Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery Completed
  29. Phase 2 Extracellular Vesicle Infusion Treatment for COVID-19 Associated ARDS Completed
  30. Phase 1 Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome Completed
  31. Phase 1 Defibrotide Therapy for SARS-CoV2 (COVID-19) Acute Respiratory Distress Syndrome (ARDS) Completed
  32. Phase 1 Human Mesenchymal Stem Cells For Acute Respiratory Distress Syndrome Completed
  33. N/A Restore Resilience in Critically Ill Children Completed
  34. N/A A Study Promoting Critical Illness Recovery in the Elderly Completed
  35. N/A Ventilator-induced Lung Injury Vortex in Patients With SARS-CoV-2 Completed
  36. N/A Comparative Effectiveness Study of Bubble CPAP Devices in the NICU Completed
  37. N/A Prehospital Telemedicine Feasibility/Acceptability Pilot Completed
  38. N/A Early PP With HFNC Versus HFNC in COVID-19 Induced Moderate to Severe ARDS Completed
  39. N/A The Role of Circulating Soluble CD74 in Acute Lung Injury Completed
  40. N/A A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation Completed
  41. N/A Retrospective Review of Mechanically Ventilated Patients Using a Continuous Data Collection System. Completed
  42. N/A ED Lung Protective Ventilation to Reduce Complications Completed
  43. N/A Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study Completed
  44. N/A Trial of Non Invasive Ventilation for Respiratoy Distress Syndrome Completed

Showing the 50 most-cited and recently-updated of 67 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Prediction models show moderate discrimination for ARDS occurrence and mortality in sepsis patients
Rheumatology Meta-analysis
Prediction models show moderate discrimination for ARDS occurrence and mortality in sepsis patients Machine Learning Models Show Mixed Results for Predicting Sepsis Lung Injury
This systematic review and meta-analysis evaluated prediction models for ARDS occurrence and short-term mortality in patients with sepsis-as…
New analysis shows that while machine learning can predict lung injury in sepsis patients, these models do not consistently outperform stand…
Frontiers Jun 9, 2026
Metabolomics profiles show elevated phenylalanine and lactate alongside depleted sphingosine 1-phosphate and citrulline in ARDS patients
Pulmonology & Critical Care Meta-analysis
Metabolomics profiles show elevated phenylalanine and lactate alongside depleted sphingosine 1-phosphate and citrulline in ARDS patients Metabolomics profiles reveal metabolic signatures in patients with acute respiratory distress syndrome
This systematic review and meta-analysis examines metabolomics profiles in patients with acute respiratory distress syndrome compared to tho…
A new analysis shows specific chemical changes in the blood of patients with acute respiratory distress syndrome compared to those without t…
Jun 1, 2026
Lung Ultrasound Shows Good Diagnostic Accuracy for ARDS in Meta-Analysis of 5888 Patients
Pulmonology & Critical Care Meta-analysis
Lung Ultrasound Shows Good Diagnostic Accuracy for ARDS in Meta-Analysis of 5888 Patients Lung ultrasound shows high accuracy for detecting severe breathing trouble in ICU patients
This systematic review and meta-analysis of 5888 patients found that lung ultrasound (LUS) has good diagnostic accuracy for acute respirator…
A large review of 5,888 patients found lung ultrasound is a highly accurate, safe way to check for severe lung injury without using radiatio…
May 1, 2026
Evidence-based review of transducer selection for lung ultrasound in dogs and cats with pulmonary pathology
Pulmonology & Critical Care Sys. Review
Evidence-based review of transducer selection for lung ultrasound in dogs and cats with pulmonary pathology Choosing the right ultrasound probe can improve lung diagnoses for dogs and cats
This evidence-based review examines transducer selection for lung ultrasound in dogs and cats with pulmonary pathology.
Veterinary lung ultrasound accuracy depends on probe choice. This review highlights how transducer selection affects diagnosis in emergency …
Frontiers May 1, 2026
Lung ultrasound and thoracic radiography for acute respiratory distress in dogs and cats
Pulmonology & Critical Care Cohort
Lung ultrasound and thoracic radiography for acute respiratory distress in dogs and cats Lung Scans Beat X-Rays for Pets in Breathing Trouble, Study Finds
This prospective observational cohort study in 144 dogs and cats with acute respiratory distress compared lung ultrasound (LUS) and thoracic…
When a pet can’t breathe, every second counts—and this research shows which test gets answers faster and more reliably.
Frontiers Apr 23, 2026
Admission blood glucose levels associated with NRDS severity in neonates
Pediatrics Cohort
Admission blood glucose levels associated with NRDS severity in neonates High blood sugar linked to worse breathing in newborns with lung distress
This retrospective cohort study of 219 neonates with NRDS at a tertiary hospital in China found that hyperglycemia at admission was associat…
Newborns with high blood sugar had more severe breathing trouble and needed longer support than those with normal sugar levels.
Frontiers Apr 23, 2026
Observational cohort study of influenza A/H1N1 pneumonia outcomes in Vietnam
Infectious Disease
Observational cohort study of influenza A/H1N1 pneumonia outcomes in Vietnam Flu Pneumonia Risk: Why Nearly Half Need ICU Care
This is a retrospective cohort study of 158 adult patients with influenza A(H1N1)pdm09 pneumonia in Vietnam.
This research highlights specific warning signs that predict severe flu complications.
medRxiv Apr 23, 2026
Intravenous Recombinant Human Plasma Gelsolin Safety and Pharmacokinetics Evaluated in Phase 1 Trial of Healthy Volunteers
Drug Pipeline RCT
Intravenous Recombinant Human Plasma Gelsolin Safety and Pharmacokinetics Evaluated in Phase 1 Trial of Healthy Volunteers Can this new IV drug be safely given? Early results show mild effects
This Phase 1 randomized controlled trial evaluated the safety and pharmacokinetics of intravenous recombinant human plasma gelsolin in 32 he…
A new IV drug caused only mild side effects in healthy volunteers, but doctors must wait for more data before using it to treat sick patient…
medRxiv Apr 19, 2026
Review of preclinical EVs for sepsis-associated acute lung injury
Pulmonology & Critical Care Sys. Review
Review of preclinical EVs for sepsis-associated acute lung injury Lungs Heal Themselves Using Body’s Own Repair System
This narrative review examines extracellular vesicles (EVs) and EV-inspired biomimetic nanosystems as a potential therapeutic approach for…
Tiny cell bubbles calm deadly lung inflammation in sepsis, offering a new way to help the body fix its own lungs during severe infections.
Frontiers Apr 18, 2026
Factors associated with time to discharge among preterm neonates in a Ugandan NICU retrospective cohort study
Pediatrics Cohort
Factors associated with time to discharge among preterm neonates in a Ugandan NICU retrospective cohort study Why Some Preterm Babies Stay in the NICU Longer
This retrospective cohort study analyzed 847 preterm neonates admitted to a Ugandan NICU to identify predictors of discharge.
Better prenatal care and local support help preterm babies go home sooner, with 70% leaving the hospital within four weeks in rural Uganda.
medRxiv Apr 18, 2026
Paracetamol or ibuprofen treatment outcomes in preterm infants with patent ductus arteriosus: a retrospective cohort analysis
Pediatrics Cohort
Paracetamol or ibuprofen treatment outcomes in preterm infants with patent ductus arteriosus: a retrospective cohort analysis Tiny Hearts, Big Risk: New Clues to a Common Preemie Problem
This retrospective cohort study evaluated pharmacological treatment with intravenous paracetamol or ibuprofen in 60 preterm infants with pat…
For the tiniest premature babies, an open heart passage that doesn't close can be life-threatening, but early treatment helps most infants r…
medRxiv Apr 18, 2026
Plasma hyaluronic acid levels predict ARDS and intubation in adult COVID-19 patients
Infectious Disease Cohort
Plasma hyaluronic acid levels predict ARDS and intubation in adult COVID-19 patients Could a simple blood test help predict who needs breathing support for COVID-19?
This retrospective single-center cohort study evaluated plasma hyaluronic acid (HA) levels in 502 adult patients with COVID-19.
High levels of a specific blood substance linked to severe lung trouble could help doctors spot who needs breathing support for COVID-19 soo…
Frontiers Apr 17, 2026

Questions about Acute Respiratory Distress Syndrome

Is prone positioning recommended for adults with moderate-to-severe COVID-19 ARDS?

Yes, prone positioning is recommended for adults with moderate-to-severe COVID-19 ARDS, especially when receiving mechanical ventilation, as it improves oxygenation and may reduce mortality.

Full answer →
Can artificial intelligence help treat patients in the intensive care unit?

Yes, AI shows promise in ICU care for tasks like ARDS subphenotyping, ventilator synchrony, and imaging analysis, but real-world use remains limited by data quality and implementation challenges.

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Can nasal high-flow oxygen replace CPAP for primary respiratory support in babies with respiratory distress syndrome?

Nasal high-flow oxygen cannot replace CPAP for primary respiratory support in babies with respiratory distress syndrome because clinical trials show it leads to significantly higher treatment failure rates compared to CPAP.

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Are LISA and ENSURE treatments equally good for preterm babies with respiratory distress syndrome?

Research shows that LISA and ENSURE are equally good at reducing the need for mechanical ventilation in preterm babies with respiratory distress syndrome.

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What are the mortality effects of prone positioning for COVID-19 Acute Respiratory Distress Syndrome?

Prone positioning for COVID-19 ARDS improves oxygenation and may reduce mortality, especially with extended sessions (>24 h), but increases pressure injury risk.

Full answer →
Does prolonged prone positioning improve oxygenation for Acute Respiratory Distress Syndrome?

Yes, prolonged prone positioning (≥24 hours) improves oxygenation in ARDS, but its effect on mortality is uncertain and it increases pressure injury risk.

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Can lung ultrasound accurately diagnose Acute Respiratory Distress Syndrome?

Yes, lung ultrasound is a reliable, non-invasive tool for diagnosing ARDS, with high specificity (87%) and good sensitivity (75%) according to a large meta-analysis.

Full answer →
See all 7 questions about Acute Respiratory Distress Syndrome →

All Acute Respiratory Distress Syndrome Articles