Observational cohort study of influenza A/H1N1 pneumonia outcomes in Vietnam.
Flu Pneumonia Risk: Why Nearly Half Need ICU Care
This is a retrospective cohort study of 158 adult patients with influenza A(H1N1)pdm09 pneumonia in Vietnam. The study found high rates of I…
This research highlights specific warning signs that predict severe flu complications.
Intravenous Recombinant Human Plasma Gelsolin Safety and Pharmacokinetics Evaluated in Phase 1 Trial of Healthy Volunteers
Can this new IV drug be safely given? Early results show mild effects.
This Phase 1 randomized controlled trial evaluated the safety and pharmacokinetics of intravenous recombinant human plasma gelsolin in 32 he…
A new IV drug caused only mild side effects in healthy volunteers, but doctors must wait for more data before using it to treat sick patient…
LSTM-based model showed improved ventilator triggering metrics compared to Auto-Trak in a small trial.
Smarter Ventilators May Finally Breathe in Sync With You
This clinical trial evaluated an LSTM-based model versus an Auto-Trak model for ventilator triggering control in 10 volunteers and 5 patient…
A new AI-powered breathing machine controller may reduce the dangerous mismatch between a ventilator's rhythm and a patient's own breathing …
Prolonged prone positioning shows oxygenation benefit but inconclusive mortality effect in COVID-19 ARDS
Longer prone positioning may improve oxygen levels in COVID-19 ARDS patients
A meta-analysis of 996 COVID-19 patients with moderate-to-severe ARDS compared prolonged (>24 h/session) to standard (≤24 h/session) prone p…
Prolonged prone positioning for severe lung failure showed a trend toward lower death rates but increased pressure injury risks in COVID-19 …
Extended prone positioning associated with lower mortality but more pressure injuries in COVID-19 ARDS
Could longer time spent face-down help more COVID-19 patients on ventilators survive?
A meta-analysis of 2412 adults with moderate-to-severe COVID-19 ARDS found extended prone positioning (≥24 h) was associated with reduced mo…
Keeping COVID-19 patients face-down longer than 24 hours lowers death risk but increases pressure sores, with no change to ventilator time.
Extracellular histones drive thrombo-inflammation in sepsis, stroke, and ARDS, review finds
Could tiny proteins released during cell death be making blood clots worse?
A systematic review synthesizes evidence on extracellular histones as damage-associated molecular patterns (DAMPs) in thrombo-inflammatory c…
Tiny proteins released when cells die may trigger dangerous blood clots and inflammation in severe illnesses like sepsis and stroke, offerin…
Hyper-oncotic Albumin Reduces Mortality in ARDS Compared to Crystalloid
Could hyper-oncotic albumin save lives in patients with severe lung issues?
Meta-analysis shows hyper-oncotic albumin reduces mortality in ARDS (OR=0.61, CI 0.43-0.85) vs. crystalloid. RCTs show no benefit.
Patients with severe lung issues had lower death rates when given hyper-oncotic albumin instead of standard fluids, though results varied by…