Phase 2
Completed N=10
The Effects of Sedatives on Tobacco Use Disorder
Source: ClinicalTrials.gov NCT03813121 ↗Enrolled (actual)
10
Serious AEs
0.0%
Results posted
Jun 2022
Primary outcomePrimary: Side Effects — 1.3; 1.4 score on a scale
Summary
This proposal will obtain preliminary data on the effect of a single sub-anesthetic dose of a sedative on cigarette craving and smoking behavior as well as measuring tolerability and acceptability.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Side Effects |
1.3; 1.4 | — |
Eligibility Criteria
Inclusion Criteria
- smoke at least 5 cigarettes per day
- smoked at least 2 years
- negative urine drug screen for psychoactive drugs and negative breath alcohol concentration
- live in Little Rock AR or surrounding area
Exclusion Criteria
- unstable or stable medical condition that would interact with study medication or participation
- serious head trauma or neurological disorder
- hypertension, abnormal ECG or metabolic blood results
- meet criteria for psychosis, schizophrenia, major depressive disorder, or bipolar disorder
- use of psychoactive drugs or medications
- BMI > 40
- among women, pregnancy or breastfeeding
Data sourced from ClinicalTrials.gov (NCT03813121). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.