Phase 3 Completed N=90 Randomized Single-blind Treatment

Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction

Source: ClinicalTrials.gov NCT03818932 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Mar 2026

Primary outcomePrimary: Pain Levels Using the Visual Analog Scale — 2.5; 4.06 score on a scale (0-10 on VAS pain scale — p=<0.001

◆ Published Evidence

No publication linked

No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.

Summary

This is a randomized, single blinded, standard of care controlled clinical trial. This project aims to compare postoperative pain control in patients in two treatment arms of anterior cruciate ligament reconstruction: a treatment group given a nonopioid pain control regimen, and a standard of care control group given standard opioid pain control regimen

Outcome Measures

Outcome	Result	p-value
PRIMARY Pain Levels Using the Visual Analog Scale	2.5; 4.06	<0.001 sig
PRIMARY Patient-Reported Outcomes Measurement Information System	61.4; 66.3	<0.001 sig

Eligibility Criteria

Eligibility Criteria:

Inclusion Criteria

All adult patients over age 18 and scheduled for a primary or revision anterior cruciate ligament reconstruction

Exclusion Criteria

Exclusion criteria will include patients with a medical history of known allergies or intolerance to allergies or intolerance to Celebrex, Tylenol, Neurontin, dexamethasone, tramadol, substantial alcohol or drug abuse, and pregnancy, history of narcotics within 6 months of surgery, renal impairment, peptic ulcer disease, GI bleeding. Secondary exclusion criterion is an intact anterior cruciate ligament reconstruction

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03818932). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.