N/A N=672 Randomized Single-blind Supportive Care

Patient-centered and Efficacious Advance Care Planning in Cancer: the PEACe Comparative Effectiveness Trial

Cancer · Advance Care Planning

Bottom Line

View on ClinicalTrials.gov: NCT03824158 ↗

Enrolled (actual)

672

Serious AEs

0.0%

Results posted

Jan 2025

Primary outcome: Primary: Advance Care Planning Engagement — 4.08; 4.34 score on a scale — p=0.0014

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Facilitated advance care planning (in-person or telephonic) (Behavioral); Web-based advance care planning (Behavioral)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Pittsburgh
Primary completion: Jan 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Advance Care Planning Engagement	4.08; 4.34	0.0014 sig
SECONDARY Number of Participants Who Have Had Advance Care Planning Discussions With Caregivers	117; 120	0.76
SECONDARY Number of Participants Who Have Had Advance Care Planning Discussions With Physicians	54; 67	0.13
SECONDARY Number of Participants Who Have Completed an Advance Directive	80; 101	0.008 sig
SECONDARY Documented Care Goals	4; 18; 1; 8; 29; 31	0.002 sig
SECONDARY Caregiver Depression Symptoms	5.87; 5.34	0.50
SECONDARY Caregiver Anxiety Symptoms	6.72; 6.56	0.84
SECONDARY Receipt of Goal-concordant End-of-life Care - Patient Wishes Followed	37; 46; 11; 2; 1; 0	0.01 sig
SECONDARY Receipt of Goal-concordant End-of-life Care - Place of Death	34; 37	0.83
SECONDARY Quality of End-of-life Care	5.62; 5.69; 5.51; 5.45; 7.67; 7.7	0.32
SECONDARY Caregiver Post-traumatic Stress Symptoms	1.15; 0.96; 1.99; 1.48; 1.06; 0.74	0.01 sig
SECONDARY Caregiver Depression Symptoms	5.87; 5.34	0.50
SECONDARY Caregiver Anxiety Symptoms	6.72; 6.56	0.84

Summary

The overall goal of this study is to identify the most effective and efficient advance care planning (ACP) strategy for patients with advanced cancer. The specific aims are to: Aim 1. Compare the effectiveness of in-person, facilitated ACP versus web-based ACP on patient and family caregiver outcomes. Aim 2. Assess implementation costs and the effects of in-person, facilitated ACP and web-based ACP on healthcare utilization at end of life. Aim 3. Identify contexts and mechanisms that influence the effectiveness of in-person, facilitated ACP versus web-based ACP.

Eligibility Criteria

Patient Inclusion Criteria:

18 years of age or older
Solid tumor
The oncologist "would not be surprised" if the patient died within the next year
Eastern Cooperative Oncology Group performance status (ECOG PS) of 0, 1, or 2
Planning to receive ongoing care at a participating oncology clinic
Willing to participate in either a web-based or facilitated program

Patient Exclusion Criteria:

Does not speak English
Inability to consent, using a validated teach-back method
Hematologic malignancy
No phone for additional study contacts and follow-up interviews
Unable to participate in advance care planning, as assessed by clinician
Unable to complete the baseline interview

Patients will be able to identify and enroll a caregiver, designated by the patient as the primary family member or friend involved in their care and best able to participate in the study.

Caregiver Inclusion criteria:

18 years of age or older
Family member or friend of an eligible patient
Primary person involved in patient's care and best able to participate in the study, as assessed by patient

Caregiver Exclusion criteria:

Does not speak English
No phone for additional study contacts and follow-up interviews
Unable to complete the baseline interview

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03824158). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.