Questions about Cancer
How does receptor discordance in metastatic breast cancer impact overall survival rates?
Receptor discordance in metastatic breast cancer is linked to worse overall survival, especially when hormone receptors are lost.
Full answer →What does a pilot study say about deep longitudinal profiling for metastatic cancer patients?
The provided sources do not contain any pilot study on deep longitudinal profiling for metastatic cancer patients.
Full answer →Does having different receptors in metastatic breast cancer lesions affect how long I live?
Yes, different receptor types in metastatic breast cancer lesions are linked to different survival times, with hormone receptor-positive subtypes generally having longer survival than HER2-positive or triple-negative subtypes.
Full answer →What immune checkpoint inhibitor is best for survival in metastatic cervical cancer?
Pembrolizumab plus chemotherapy is the best-supported immune checkpoint inhibitor for improving overall survival in metastatic cervical cancer, especially in PD-L1 positive patients.
Full answer →Does the neutrophil-to-lymphocyte ratio predict progression-free survival in metastatic cervical cancer patients?
A high neutrophil-to-lymphocyte ratio (NLR) before treatment predicts shorter progression-free survival in metastatic cervical cancer patients receiving immunotherapy, while a low ratio suggests better outcomes.
Full answer →How does the neutrophil-to-lymphocyte ratio predict survival in metastatic cervical cancer treated with immune therapy?
A lower neutrophil-to-lymphocyte ratio (NLR) before starting immune therapy predicts longer survival and better response rates in metastatic cervical cancer, while a higher ratio signals a worse outlook.
Full answer →What evidence exists for liver cancer alongside lung, breast, and kidney cancer?
Research shows liver cancer detection using liquid biopsies has high accuracy similar to lung, breast, and kidney cancers, while survival rates for liver cancer have improved significantly in recent years.
Full answer →Can machine learning with cfDNA help detect liver cancer at different stages?
Yes, machine learning with cfDNA can detect liver cancer at various stages, with sensitivities ranging from 44% for stage I to 99% for stage III and high specificity.
Full answer →All Cancer Articles
- SLE patients have significantly higher odds of HPV infection and associated cancers
- Ponatinib combined with blinatumomab achieves 84% overall survival in Philadelphia chromosome-positive acute lymphoblastic leukemia
- Atezolizumab and bevacizumab plus TACE improves TACE-PFS to 11.30 months versus 7.03 months
- Combined US and MRI model yields significantly higher diagnostic accuracy for predicting microvascular invasion in HCC
- Antibiotic exposure is associated with shorter overall survival in hepatocellular carcinoma patients on ICIs
- Hepatectomy plus splenectomy improves overall survival and recurrence-related survival in patients with hepatocellular carcinoma
- Mindfulness-based cognitive therapy significantly reduces psychological distress, depression, and anxiety in cancer patients
- Bone metastasis and anxiety significantly increase the risk of pain crises in cancer patients
- Fertility treatments are associated with a modestly elevated risk of melanoma in women
- Periostin correlates with advanced clinical stage and poor prognosis in multiple solid tumor types
- CDKN3 expression varies across cancer types and lacks a universal role in tumor progression
- Malignancy linked to higher mortality in sepsis, with pooled odds ratios up to 2.41
- Lower SLC25A28 expression linked to shorter survival in glioma, pooled HR 1.91
- Immune cell functional remodeling and pre-metastatic niche construction drive tumor metastasis and immune editing
- Cold atmospheric plasma may enhance T-cell infiltration and immune checkpoint blockade response in cancer
- Barriers to clinical trial participation in rural Australia include cultural gaps and logistical costs
- Therapy-associated tissue remodeling creates complex environments that may influence tumor persistence and relapse
- Comprehensive diagnostic evaluation identifies HPV-associated squamous cell carcinoma in a patient with a pelvic mass
- A mechano-metabolism-lactylation feedback loop drives tumor metastasis and promotes immune evasion and resistance
- Dual immune checkpoint inhibition provides durable intracranial progression-free survival in melanoma patients with brain metastases
- Obesity-induced neuroinflammation and neuroimmunometabolic feedback may reshape the tumor microenvironment in cancer patients
- Cancer cachexia is associated with higher odds of postoperative complications in gastrointestinal cancers
- Lysine crotonylation drives tumor progression and may potentiate immunotherapy response in various solid tumors
- AKR1B10 may serve as a serum biomarker for AFP-negative hepatoblastoma subtypes
- AI decision support improves detection in bounded tasks but not in open-ended reasoning
- Specific natural products modulate the NRF2-ferroptosis axis in preclinical models of hepatocellular carcinoma
- Viral infections in the tumor immune microenvironment modulate immune cell functions and cytokine networks
- Extracellular targeted protein degradation offers diverse preclinical opportunities for targeting tumor immune microenvironment components
- Diverse expansion methods and automated platforms offer pathways to scalable CAR-T cell manufacturing
- Nurse-led interventions improve medication adherence and reduce toxicity in patients receiving targeted anti-tumor therapies
- miR-155 overexpression is frequently associated with treatment resistance across 8 cancer types
- Epidemiological studies report a modest bidirectional inverse association between cancer and Alzheimer disease
- Mindfulness-based cancer recovery and Tai Chi/Qigong improve fatigue and pain interference in cancer survivors
- Prolonged scalp hypothermia improves hair preservation in cancer patients compared to usual care and traditional methods
- Rapid growth in tumor immunometabolism research since 2020 reflects expanding interest in immunotherapy
- Surgical resection plus postoperative TACE yields recurrence-free status in rare primary clear cell liver carcinoma
- PD-1/PD-L1 inhibitors with SRS or FSRT achieve 87% one-year local control in brain metastases
- Hashimoto's thyroiditis functions as a dual-natured immune microenvironment in differentiated thyroid cancer
- DUBs sustain cancer stem cell plasticity via EMT and metabolic reprogramming
- Structured framework sets 16 quality indicators for animal cancer registries
- Non-targeted effects and signaling factors may influence DNA damage and repair in radiation therapy
- cGAS-STING pathway serves as a central axis for innate immune activation in MASLD and HCC
- Camrelizumab plus chemotherapy is cost-effective for first-line treatment of advanced squamous non-small-cell lung cancer
- Genetic risk factors and a validated polygenic risk score identify melanoma risk loci
- Erdafitinib improves overall survival in FGFR3-altered urothelial carcinoma with HR 0.64 compared to chemotherapy
- PD-L1 and CTLA-4 Variants Linked to Genitourinary Cancer Risk
- Zanidatamab with chemotherapy or tislelizumab achieves 70% objective response rate in HER2-positive gastroesophageal adenocarcinoma
- VRE Prevalence 18.4% in Hematologic Malignancy Patients, Pooled Meta-Analysis Finds
- Enzalutamide added to ADT improves survival in APIC-negative metastatic hormone-sensitive prostate cancer
- Equity-centered precision oncology framework addresses systemic disparities in pediatric and AYA cancer care
- Phase 3 monotherapy trials show superior objective response rates and survival in solid malignancies
- 18F-FDG PET/CT SUVmax and TLR are associated with increased microvascular invasion risk in HCC
- CIC-Rearranged Intracranial Sarcoma: Local Control Achieved but Distant Spread Rapid Despite Multimodal Therapy
- Intrathecal therapy using partially implanted devices reduces pain intensity and opioid use in refractory cancer pain
- Long-Surviving PDAC With HRR Alterations May Face CNS Sanctuary Relapse
- Radiotherapy and ferroptosis-directed interventions may enhance immune checkpoint inhibitor response in refractory tumors
- Carrier-free self-assembled nanodrugs lack sufficient reporting on batch consistency and long-term toxicity data
- UHDR proton beam FLASH technology requires specific radiation protection for institutional research programs
- Dose-dense temozolomide shows no significant difference in progression-free survival compared to standard radiotherapy
- 15 germline loci associated with hepatocellular carcinoma identified across multiple ancestries
- mRNA vaccines provide a clinically validated platform to induce durable anti-tumor immunity in solid tumors
- Pembrolizumab, regorafenib, and cabozantinib improve overall survival in advanced hepatocellular carcinoma after prior therapies
- HAIC combined with TKI and PD-1 inhibitor improves overall survival in unresectable hepatocellular carcinoma
- da Vinci robot-assisted surgery reduces conversion to open surgery and blood loss in oncologic procedures
- CD160-HVEM axis signaling drives T-cell exhaustion in cancer and promotes allograft rejection
- Immune checkpoint inhibitors show clinical activity in non-epithelioid pleural mesothelioma subtypes
- Programmable mRNA platforms show significant growth in research focus for cancer-associated immune escape
- HDAC inhibitors show 0.65 pooled favorable response rate in advanced head and neck cancer
- Artificial Intelligence Performance in Diagnosing Oral Potentially Malignant Disorders via Intraoral Photography
- Low-grade glioma makes up 57% of mixed-grade glioma surgical cohorts, meta-analysis finds
- EQ-5D Utility Values and Health Related Quality of Life
- Fungal dysbiosis is associated with altered community structures and immune remodeling in several gastrointestinal cancers
- Selenium Shows Inconclusive Mucositis Benefit in Cancer Therapy, Exploratory Toxicity Reduction
- Degradable Starch Microspheres TACE shows no significant improvement in survival for hepatocellular carcinoma
- Low tumor volume reduction on CT and high FDG-PET SUVmax correlate with poorer outcomes in head and neck cancer
- Robot-assisted partial nephrectomy reduces hospital stay and transfusion risk compared to open partial nephrectomy
- Nursing strategies for inflammation-sensitive care can mitigate complications and preserve physiologic reserve in gynecologic oncology surgery
- Enfortumab vedotin cutaneous toxicity and peripheral neuropathy are associated with improved outcomes in urothelial carcinoma
- Natural polysaccharides may synergize with anti-PD-1/PD-L1 immunotherapy through gut microbiota and TME remodeling
- Smoking history linked to worse survival in HPV-positive oropharyngeal cancer after TORS
- Hope functions as a dynamic, metamorphic force for children and families facing cancer diagnoses
- Broader liver transplant eligibility criteria show no difference in survival outcomes for hepatocellular carcinoma
- Conversion therapy yields 25.4% pooled resection rate in unresectable HCC across 34 studies
- Intersphincteric resection reduces local recurrence and improves five-year survival in lower rectal cancer
- Impact of Antidiabetic Medications on Survival Outcomes in Patients with Cancer
- Surgery for NCRNNE GI Liver Metastases Tied to Better 1-Year Survival
- Individualized treatment planning for synchronous bilateral primary breast cancer is supported by independent lesion characterization
- RTK-RAS pathway alterations are more frequent in cholangiocarcinoma than in hepatocellular carcinoma
- Extended rhythm monitoring identifies 64% of asymptomatic atrial fibrillation in patients on BTKi therapy
- Evaluating Cytokine and Molecular Biomarkers for Diagnosing Primary Vitreoretinal Lymphoma
- Blinatumomab plus chemotherapy improves disease-free and overall survival in pediatric B-ALL
- Artificial Intelligence Performance in Dermatoscopic Image Interpretation for Skin Cancer Diagnosis
- Five-Element Music Therapy Impacts Psychological Wellbeing and Physiological Markers in Chemotherapy Patients
- Brexucabtagene autoleucel achieves 88% overall response rate in relapsed or refractory mantle cell lymphoma
- Systemic barriers like delayed diagnosis and limited surgery impact survival in high-grade gliomas
- Home-based exercise rehabilitation may improve cardiorespiratory fitness and quality of life in cancer
- Cancer patients exhibit significantly lower heart rate variability indices compared to age-matched controls
- Nanophotothermal systems using chitosan and hyaluronic acid provide real-time monitoring and multi-functional drug delivery
- Intravesical drug delivery systems improve urothelial drug deposition and allow repurposing of systemic agents
- Tonsillar metastasis in hepatocellular carcinoma patients may present as undifferentiated carcinoma with specific IHC markers
- Ophthalmic imaging and phenotype-based frameworks aid diagnosis of rare and heterogeneous choroidopathies
- Tumor dormancy creates a reservoir of drug tolerance and may trigger disease relapse in cancer
- AI tongue image analysis shows variable accuracy for gastric cancer screening
- Immunocytokines offer improved safety profiles compared to systemic cytokine therapy in cancer treatment
- Auriculotherapy Shows Consistent Pain Relief Across Multiple Conditions
- Clinicoradiomics models provide superior and more consistent performance for predicting microvascular invasion in hepatocellular carcinoma
- Virtual reality interventions significantly reduce anxiety scores in patients with various types of cancer
- Approximately 40% to 55% of patients with advanced melanoma exhibit primary resistance to PD-1 monotherapy
- Tumor-activated prodrug nanoparticles improve specificity and remodel the immune microenvironment in cancer therapy
- Astragaloside IV modulates tumor microenvironment and macrophage polarization in hepatocellular carcinoma models
- CAR-T in solid tumors: 13% ORR, 63% DCR, lymphopenia most common AE
- Structured Exercise Linked to Better Survival in Adults With Cancer
- Cognitive biases and system barriers contribute to diagnostic delays in thoracic and mediastinal conditions
- Immune checkpoint inhibitor and chemotherapy combination improves pathological response in gastric adenocarcinoma
- Pulmonary lymphangitic carcinomatosis may mimic interstitial lung disease in patients with gastric adenocarcinoma
- High CALLY index correlates with improved survival in hepatobiliary and pancreatic malignancies
- Ropeginterferon alfa-2b increases complete hematologic response from 26% to 59% in polycythemia vera
- AENK-T cell fate is determined by specific receptor emergence and transcriptomic axes during exhaustion
- Combined exercise is most effective for cancer-related fatigue and lean mass in breast cancer
- Exergaming shows favorable outcomes for mobility, balance, and fatigue in adults with cancer
- Hypoxia coordinates cancer stem cell phenotypes with immune-related mechanisms and therapeutic resistance in cancer
- Psychosocial Interventions Improve Neurocognitive, Psychological, and Quality-of-Life Outcomes in Children With Cancer
- MITF E318K variant associated with significantly increased melanoma risk and high nevus burden
- Early Palliative Care Improves Quality of Life and May Extend Survival in Cancer
- Immunonutrition provides the strongest evidence for perioperative immune homeostasis in gastrointestinal cancer surgery
- Yangyin Fuzheng Jiedu plus minimally invasive treatment improves recurrence-free survival in early-stage hepatocellular carcinoma
- Nutrition-oriented perioperative nursing supports management of frailty and malnutrition in older women with cancer
- Melanoma Immunoediting Review Maps Elimination, Equilibrium, Escape and Drivers of Immunotherapy Resistance
- NALIRIFOX shows no significant difference in overall survival compared to FOLFIRINOX in pancreatic cancer
- Psychological, social, and behavioral barriers and facilitators influence prehabilitation adherence in cancer patients before surgery
- Exercise interventions improve bone mineral density, cardiorespiratory endurance, and quality of life in children with acute leukemia
- SMMI framework provides a conceptual model for risk stratification in high-risk oral potentially malignant disorders
- Evidence Map Finds Sparse Direct Data on Cancer Care Barriers for Immigrant Workers
- Long-read sequencing and assembly tools facilitate detection of complex viral integration structures in various cancers
- USP family deubiquitinases regulate p53, PTEN, c-Myc, and PD-L1 to drive tumor progression
- Exosomal miRNAs Show High Diagnostic Accuracy for Hepatocellular Carcinoma
- Trastuzumab Deruxtecan Management of HER2 Positive Metastatic Breast Cancer with Visceral Crisis
- PIWIL4 exhibits context-dependent roles in cancer progression and metabolic reprogramming across various cancer types
- GPX4-targeted chemical strategies present bidirectional roles and specific translational barriers in multiple disease states
- Medicinal plant extracts and phytochemicals show potential as multitargeted candidates for metastatic melanoma
- Astragalus Polysaccharides and Astragaloside IV Modulate Immunity and Tumor Metabolism in Preclinical Cancer Models
- Self-administered ivermectin and fenbendazole in a patient with metastatic melanoma showed mixed radiographic and ctDNA responses
- MDT-guided perioperative strategy and staged anticoagulation manage pancreatic cancer in a patient with Moyamoya disease
- RPN1 overexpression promotes immune evasion and treatment resistance in multiple malignancies including hepatocellular carcinoma
- Polyherbal Unani Formulation Targets TGF-beta/Smad, NF-kappaB, and PI3K/Akt Pathways in Fibrosis and Cancer
- Intraoperative dexmedetomidine use does not significantly impact overall survival or recurrence-free survival in cancer patients
- ADC resistance in bladder cancer is multifactorial, review finds, with no validated overcoming strategy
- Dioscin shows therapeutic potential for various liver disorders including MASLD and hepatocellular carcinoma
- Hamburg Life After Cancer Program protocol aims to improve quality of life in cancer survivors
- Rezvilutamide plus ADT with efavirenz-based ART yields PSA decline in one HIV-positive mHSPC patient
- Spatial immune-ecology framework proposed for gastric and GEJ adenocarcinoma ICI selection
- FDA-approved AI solutions for cancer histopathology are limited to a narrow range of applications
- IMRT plus cetuximab does not improve quality of life compared to IMRT plus cisplatin
- Postoperative conventional fractionation radiotherapy is more cost-effective than preoperative accelerated fractionation for oral cavity cancer
- Radiation therapy and nasopharyngeal cancer significantly increase risk of chronic rhinosinusitis in head and neck cancer patients
- Egg consumption associated with reduced glioma risk in Eastern populations and increased head and neck cancer risk
- Quercetin immunity research surges, mapping review finds 12 thematic clusters
- Four mailer types aim to increase health care proxy documentation in patients with chronic conditions
- Splenic hilum nodal involvement is rare in pancreatic body adenocarcinoma with a 1.1% prevalence
- MRI-based radiomics models achieve 0.91 AUC for predicting GPC3 expression in hepatocellular carcinoma
- Nurse-coordinated monitoring of biomarkers and symptoms supports clinical assessment for immune checkpoint inhibitor safety
- Gut microbiome composition correlates with clinical outcomes in hepatocellular carcinoma patients treated with immune checkpoint inhibitors
- Encorafenib and Binimetinib Combination Therapy for Patients with BRAF Mutated Cutaneous Melanoma
- Triple Combination Therapy Improves Progression-Free Survival in Patients with Hepatocellular Carcinoma
- Evaluating AI and Manual Stromal Immune Cell Quantification in HER2 Positive Breast Cancer
- Empowered Survivor digital tool boosts self-efficacy in oral cancer survivors
- Physical exercise during neoadjuvant chemotherapy does not significantly improve pathologic complete response in solid tumors
- Play interventions significantly reduce anxiety and depressive symptoms in children with cancer
- Most oncology professionals lack prior training in integrative medicine despite emerging curriculum needs
- Bidirectional crosstalk between hepatic stellate cell-derived CAFs and T cells drives immune evasion in HCC
- Meridian Sinew Tuina significantly reduces upper limb circumference and pain in breast cancer-related lymphedema
- Objective response rate correlates with overall survival in nivolumab-containing regimens for metastatic melanoma
- Bispecific antibodies improve progression-free survival and overall survival in patients with solid tumors
- Higher pretreatment HALP score is associated with improved overall survival in head and neck cancer
- Multiparametric MRI and image-guided neurointerventions provide critical roles in brain tumor management and surveillance
- Delayed margin formation in lung tumor microwave ablation may occur despite lack of immediate intraprocedural margin
- Mitophagy acts as a core barrier to effective immunotherapy in melanoma and other skin cancers
- Radioactive iodine does not significantly reduce recurrence in low-risk differentiated thyroid cancer
- eREACH digital intervention meets non-inferiority for genetic service uptake and anxiety in cancer patients
- Machine learning predicts Ki-67 in renal tumors with moderate accuracy, AUC 0.85 to 0.86
- C3-derived skeletal muscle index shows strong correlation with L3 index in head and neck cancer
- CLDN18.2 expression prevalence of 33.99% in patients with gastric and gastroesophageal junction adenocarcinoma
- Post-translational modifications drive drug resistance in hepatocellular carcinoma, systematic review finds
- Cold atmospheric plasma modulates immune signaling pathways and macrophage polarization in infection and cancer models
- Docetaxel and PARPi additions to ARPI and ADT improve progression-free survival in mHSPC
- Disitamab vedotin and tislelizumab combination achieved remission of skin metastasis in a patient with bladder carcinoma
- High Siglec-15 Tumor Expression Tied to Worse Survival
- Bispecific antibodies improve progression-free survival and overall survival in patients with solid tumors
- Age and sex drive distinct immune microenvironment and evasion mechanisms in cancer patients
- High CAR-HEMATOTOX scores correlate with increased ICAHT odds and worse survival in CAR T-cell therapy
- Approximately 61% of cancer patients resume anticancer treatment after unplanned ICU admission
- Machine learning models predict cancer symptoms with AUC values ranging from 0.76 to 0.86
- Local therapies for liver, lung, and locoregional recurrence improve survival in pancreatic ductal adenocarcinoma
- Digital CBTi reduces insomnia severity scores more than telephone or group delivery methods
- Multidisciplinary Palliative Rehabilitation Improves Quality of Life in Advanced Life Limiting Illness
- Prevotella exhibits dual pro-tumorigenic and anti-tumorigenic roles in gastrointestinal cancer progression
- Oral frailty affects 52% of cancer patients, meta-analysis finds
- Metabolic risk factors including diabetes and metabolic syndrome are associated with increased hepatocellular carcinoma risk
- Malnutrition and sarcopenia are associated with poorer treatment tolerance and higher toxicity in head and neck cancer
- Splicing-derived neoantigens provide diverse target classes for T-cell and antibody-based cancer immunotherapies