Questions about Cancer
How does receptor discordance in metastatic breast cancer impact overall survival rates?
Receptor discordance in metastatic breast cancer is linked to worse overall survival, especially when hormone receptors are lost.
Full answer →What does a pilot study say about deep longitudinal profiling for metastatic cancer patients?
The provided sources do not contain any pilot study on deep longitudinal profiling for metastatic cancer patients.
Full answer →Does having different receptors in metastatic breast cancer lesions affect how long I live?
Yes, different receptor types in metastatic breast cancer lesions are linked to different survival times, with hormone receptor-positive subtypes generally having longer survival than HER2-positive or triple-negative subtypes.
Full answer →What immune checkpoint inhibitor is best for survival in metastatic cervical cancer?
Pembrolizumab plus chemotherapy is the best-supported immune checkpoint inhibitor for improving overall survival in metastatic cervical cancer, especially in PD-L1 positive patients.
Full answer →Does the neutrophil-to-lymphocyte ratio predict progression-free survival in metastatic cervical cancer patients?
A high neutrophil-to-lymphocyte ratio (NLR) before treatment predicts shorter progression-free survival in metastatic cervical cancer patients receiving immunotherapy, while a low ratio suggests better outcomes.
Full answer →How does the neutrophil-to-lymphocyte ratio predict survival in metastatic cervical cancer treated with immune therapy?
A lower neutrophil-to-lymphocyte ratio (NLR) before starting immune therapy predicts longer survival and better response rates in metastatic cervical cancer, while a higher ratio signals a worse outlook.
Full answer →What evidence exists for liver cancer alongside lung, breast, and kidney cancer?
Research shows liver cancer detection using liquid biopsies has high accuracy similar to lung, breast, and kidney cancers, while survival rates for liver cancer have improved significantly in recent years.
Full answer →Can machine learning with cfDNA help detect liver cancer at different stages?
Yes, machine learning with cfDNA can detect liver cancer at various stages, with sensitivities ranging from 44% for stage I to 99% for stage III and high specificity.
Full answer →All Cancer Articles
- Warming-dredging acupuncture significantly improves pain relief rates for patients with cancer-related pain
- Preoperative inflammatory biomarkers SIRI and NLR associate with worse survival in UTUC after RNU
- Financial toxicity and food insecurity create a health-economic pathway impacting nutrition in women with cancer
- Metabolic reprogramming and plasticity drive tumor progression and resistance through interconnected transcription factors and enzymes
- AI-assisted clinicians achieve 1.000 sensitivity in melanoma diagnosis but autonomous AI lacks clear clinical advantage
- Immunonutrition may improve management of radiation-induced oral mucositis in head and neck cancer patients
- Acidic microenvironments reprogram immune cells via pH sensors, driving tissue injury
- CAR T-cell therapies targeting specific antigens show potential for treating pediatric CNS tumors
- Evaluating Bevacizumab Addition to Atezolizumab Carboplatin and Pemetrexed in Nonsquamous NSCLC
- Postoperative radiotherapy reduces local and peristomal recurrence rates in laryngeal cancer patients with preoperative tracheotomy
- EGFR and TP53 mutations linked to worse survival in sinonasal squamous cell carcinoma
- Completion thyroidectomy follows total thyroidectomy for similar operative safety in differentiated thyroid cancer
- Zygomatic implants provide high survival rates for maxillary reconstruction in head and neck cancer patients
- Nurse-led telehealth interventions significantly improve psychosocial outcomes and quality of life in palliative cancer care
- Diverse therapeutic approaches including immunotherapy are utilized for patients with occult squamous cell carcinoma
- Metabolic checkpoints like lactate and adenosine drive immune escape and resistance to checkpoint blockade
- Laryngeal obstruction as initial sign of MEN2B in two pediatric cases with RET mutations
- Natural products modulate non-apoptotic cell death to bypass apoptotic blockades in cancer
- Chinese herbal medicine research for cancer pain management shows steady growth in publication volume
- Bibliometric Analysis Maps Paraptosis Research Landscape in Cancer
- T cell signaling and metabolic rewiring are critical for T cell engager efficacy in solid tumors
- Evidence-based guidelines support team-based perioperative glycemic management for patients with hepatocellular carcinoma
- OTUD1 serves as a potential biomarker for tumor prognosis and cardiovascular disease progression
- Comparative Analysis of Robot Assisted and Laparoscopic Partial Nephrectomy for Renal Tumors
- Forty-seven clinically relevant late-phase programs identify development trajectories for PD-1 and PD-L1 therapies through 2030
- FTO-targeted strategies currently lack clinical evaluation and rely on preclinical evidence for cancer treatment
- IEN plus NACT shows greatest improvement in CD4+ counts among ranked strategies
- Elevated serum M2BPGi is associated with a 4.61 hazard ratio for hepatocellular carcinoma development
- Opsin 3 serves as a potential therapeutic target for melanoma and inflammatory skin diseases
- Problem-focused coping is moderately to strongly associated with benefit finding in adult cancer patients
- AI diagnostic tools show high accuracy but limited real-world validation in systematic review
- Image-guided RFA and MWA show comparable efficacy and safety for small to medium hepatocellular carcinoma
- Parasite-derived molecules exert both pro-tumour and anti-tumour effects in experimental cancer models
- Proposed CTS protocol aims to convert cold tumors to hot and improve immunotherapy response
- Scavenger receptor-guided and cathepsin B-triggered nanodelivery systems enable targeted macrophage remodeling for atherosclerosis and cancer
- Direct-acting antivirals achieve 89% sustained virologic response in patients with hepatocellular carcinoma and HCV
- Prophylactic PEG tube placement improves nutritional status and reduces hospitalizations for head and neck cancer patients
- Gut microbiome taxa and metabolites enhance immune checkpoint inhibitor efficacy and mitigate systemic toxicity
- LncRNA signatures predict ICI response and survival across cancers in systematic review
- Immune checkpoint inhibitors are associated with acute kidney injury and multi-organ immune-related adverse events
- Axicabtagene ciloleucel shows higher early response but greater toxicity than tisagenlecleucel in large B-cell lymphoma
- KRAS G12C inhibitors improve progression-free survival with HR 0.62 in KRASG12C-mutated solid tumors
- Hangeshashinto may reduce oral mucositis risk in chemotherapy patients (RR 0.86)
- TSH suppression therapy promotes tumor progression via G-protein signaling pathways in differentiated thyroid cancer
- Synergistic Effects of Immune Checkpoint Inhibitors and Radiotherapy in Solid Tumor Management
- Actinic keratosis increases melanoma risk while alcohol consumption is associated with lower squamous cell carcinoma risk
- Percutaneous Cervical Cordotomy reduces pain and opioid consumption in patients with severe cancer pain
- Mandala painting and music therapies improve quality of life and psychological well-being in cancer survivors
- Sugar sweetened beverages and orange juice are associated with increased risk of several cancer types
- Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
- EGFR inhibitors show reproducible activity and manageable toxicity in locally advanced or metastatic anal squamous cell carcinoma
- HITHOC with cytoreductive surgery improves survival in pleural mesothelioma without raising early postoperative risk
- Peer support may impact fear of disease progression and psychological symptoms in patients with glioma
- Radiomics-based artificial intelligence models predict VETC presence in patients with hepatocellular carcinoma
- Liquid biopsy technologies utilizing NGS and machine learning improve analytical sensitivity for early cancer detection
- Rural residence and poor knowledge increase odds of delayed health-seeking behavior for cancer patients
- Multicomponent nonpharmacological interventions reduce delirium incidence in adult patients with cancer
- Higher log GDP per capita is associated with higher Comprehensive Score for Financial Toxicity
- Dysregulation of tRNA expression, modification, and tsRNAs is linked to tumor proliferation and therapy resistance
- Dendritic cell-based therapies face significant clinical translation barriers due to tumor microenvironment suppression
- Immersive virtual reality significantly reduces anxiety and pain in patients with gastrointestinal cancer
- Robot-assisted radical nephrectomy reduces conversion rates and blood loss compared to laparoscopic surgery for complex tumors
- Tumor-infiltrating pDCs lose interferon production despite nucleic acid exposure
- Motivation-informed digital reminders do not improve task completion compared to standard wording in melanoma trial
- IO102-IO103 plus pembrolizumab improves progression-free survival in advanced melanoma patients
- Dexmethylphenidate significantly improves cancer-related fatigue compared to placebo with moderate evidence certainty
- Cancer presence associated with OR 1.88 for early mortality following coronary artery bypass grafting
- FANCI overexpression linked to poor prognosis in multiple cancers, review finds
- Next-generation engineered constructs aim to overcome immunosuppressive tumor microenvironments in refractory malignancies
- Immune crosstalk between innate and adaptive compartments drives inflammatory mechanisms in MASLD and MASH progression
- Acupuncture Efficacy in Managing Cancer Related Fatigue and Quality of Life
- Meta-analysis Evaluating Occupational Hexavalent Chromium Exposure and Specific Malignancy Risks
- Extended resection and intensity-modulated radiotherapy managed a rare primary orbit epithelioid sarcoma
- High PTTG1 expression correlates with poorer survival and advanced disease in various solid tumors
- Walking training improves VO2 peak and reduces fatigue in adult cancer patients
- Zinc supplementation shows potential in reducing severe radiation-induced oral mucositis in head and neck cancer patients
- Mendelian Randomization Evaluates IL-6 Inhibition Effects on Hepatocellular and Colorectal Cancer Risk
- cGAS-STING signaling pathway activation drives inflammation, fibrosis, and functional decline in various kidney diseases
- Depression prevalence reaches 50.9% among patients with advanced cancer receiving palliative care
- Metabolic reprogramming of lipid-associated macrophages creates an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
- Atypical granular cell tumor requires immunohistochemical detection and multimodal imaging to avoid common misdiagnosis as schwannoma
- Combination of Local Treatment and Systemic Therapy Improves Outcomes in Patients with Hepatocellular Carcinoma
- Robot-assisted inguinal lymphadenectomy reduces the odds of total postoperative complications in penile cancer patients
- Trastuzumab deruxtecan and pyrotinib provide disease control in lung squamous cell carcinoma with ERBB2 mutation
- Solid organ transplant recipients face higher cancer-related mortality with SMR 2.21 across multiple organs
- Low PNI and GNRI correlate with poorer survival in elderly patients with early gastric cancer
- Protein lactylation promotes tumor cell malignancy and drives immune evasion in the tumor microenvironment
- Symptomatic radiation necrosis occurs in 5.7% of intracranial brachytherapy patients
- Serplulimab plus chemotherapy improves overall survival compared to chemotherapy alone in nsq-NSCLC
- I-SPECT/CT shows high patient-level specificity of 0.95 for detecting residual disease in DTC
- Immunohistochemical profiling helps differentiate synchronous primary breast invasive carcinoma from metastatic ovarian carcinoma
- LDHA promotes malignant progression and drug resistance while modulating tumor-infiltrating immune cell differentiation
- Astragalus membranaceus derivatives restore immune tolerance and homeostasis in digestive system diseases
- Anti-CD19 shRNA-engineered CAR-T cells achieve an 88% overall response rate in B-cell acute lymphoblastic leukemia
- Hemithyroidectomy is associated with a 3% higher risk difference in cancer recurrence rate
- Pseudoprogression in immune checkpoint inhibitor therapy is associated with modest tumor growth and early progression
- Intracranial immunotherapy delivery does not improve survival for pediatric high-grade glioma compared to systemic administration
- Circular RNAs may regulate ferroptosis and anti-tumor immunity in cancer via multiple mechanisms
- Fibromyalgia as an oncology comorbidity increases symptom burden and impairs treatment adherence
- Immune-based combinations show superior overall survival compared to sorafenib in advanced hepatocellular carcinoma
- EBUS-TBNB yields higher diagnostic rates for lymphoma and sarcoidosis compared to EBUS-TBNA
- MRI Radiomics Predicts TERTp Mutation in Glioma with Moderate Accuracy
- Comprehensive palliative care improves quality of life, survival, and symptoms in thoracic cancer patients
- Curcumin as a theranostics agent: intrinsic fluorescence and protein affinity offer dual diagnostic and therapeutic potential
- Signet ring morphology in gastric biopsies may mask metastatic invasive lobular carcinoma from breast cancer
- Long-read sequencing improves detection of structural variants and methylation patterns in liquid biopsy
- Multitarget designs and microenvironment remodeling may overcome resistance to CAR T-cell therapy in B-cell malignancies
- OTUD7B acts as a context-dependent regulator in various cancers and inflammatory conditions
- EMR integrated platform improves data abstraction efficiency and speed for cancer patient records
- Advanced experimental models and computational tools provide dynamic frameworks for understanding oral disease progression
- NODI parameters ODI and V-ISO differentiate gliomas from brain metastases in contrast-enhancing regions
- TRAM MRI shows 0.89 AUC for differentiating treatment response from radionecrosis in CNS tumors
- Tislelizumab plus chemotherapy improves survival in extensive-stage small cell lung cancer
- Artificial intelligence as a mechanistic microscope and digital twin in colorectal cancer faces generalizability and regulatory validation limitations
- E-health self-management interventions improve quality of life in cancer patients with a standardized mean difference of 0.18
- Screening and management strategies for stigma in patients with colorectal cancer and stomas require clinically meaningful guidance
- Diagnostic prediction models show moderate-to-good discrimination for cancer-related fatigue
- Low pretreatment lymphocyte-to-monocyte ratio linked to worse survival in cervical cancer
- Narrowband UVB remains first-line phototherapy for vitiligo, with JAK inhibitors emerging as adjuncts
- Conversion surgery after induction therapy improves 5-year survival to 26.5% versus 11.6% in cT4 esophageal cancer patients
- CDK4/6 inhibitors show therapeutic potential in advanced gastrointestinal cancers, review finds
- Mitochondria-targeted strategies show translational potential for improving radiosensitivity in radioresistant tumor cells
- Local radiopharmaceutical production reduces therapy costs by 93% to 96% across 54 African nations
- Angiogenesis inhibitors combined with chemotherapy improve progression-free survival in advanced breast cancer patients
- Lower baseline quality of life linked to 7% higher mortality risk in lung cancer patients
- Microbial metabolites may promote or suppress cancer progression through inflammation, DNA damage, or immune modulation
- Exercise-induced myokines show functional duality with tumor-suppressive or tumor-promoting effects depending on microenvironmental context
- Cadmium exposure linked to higher endometrial cancer risk, while PCBs show no association in meta-analysis
- Hypofractionated and dose-boosted radiotherapy improves metastasis-free survival in clinically localised prostate cancer
- Meta-analysis links baseline and dynamic ctDNA to survival in advanced NSCLC
- Datopotamab deruxtecan showed no overall survival benefit versus investigator's choice chemotherapy in metastatic HR-positive breast cancer.
- Lenvatinib plus PD-1 inhibitor improves survival versus bevacizumab plus PD-1 inhibitor in unresectable hepatocellular carcinoma
- Meta-analysis finds modest melanoma risk increase among infertile women using fertility treatments
- Combination immunotherapy and targeted therapy regimens show favorable survival outcomes versus monotherapies in unresectable hepatocellular carcinoma
- Network meta-analysis finds similar overall survival for three HCC regimens
- Low-intensity cervical screening shows similar CIN2+ risk to high-intensity screening in HPV-vaccinated women
- WBRT shows no significant survival benefit in thyroid cancer brain metastases meta-analysis
- Wearable monitoring reduced prolonged hospital stay from 24% to 7% in lung cancer surgery cohorts
- Metal-based nanomaterials show promise for cancer phototherapy in preclinical models
- Isoliquiritigenin shows significant anti-ovarian cancer effects with low toxicity as a promising natural candidate for targeted therapy
- TEAS significantly reduces overall PONV risk in patients undergoing breast surgery compared to sham stimulation or routine care
- Volume doubling time under 200 days marks all malignant nodules in 27 studies of lung cancer screening programs
- Ultrasound-driven mechanical immunomodulation shows promise for tumor therapy but faces key hurdles
- Rate of drug concentration rise alters hemodynamic responses and mortality risk in coronary heart disease patients
- Meta-analysis finds rheumatoid arthritis associated with increased thyroid cancer risk in pooled cohort data
- Combination therapy with 3M-052 and anti-TNFR2 antibody suppressed colon cancer growth in mouse models while enhancing immune response
- Cetuximab maintenance therapy prolongs progression-free survival and overall survival versus observation in metastatic colorectal cancer
- Molecularly engineered BODIPY photosensitizers combined with immunotherapeutic strategies show potential for cancer treatment
- Statins reduce recurrence risk 23% and mortality in 267,913 HR+ breast cancer patients with HR 0.77
- cGAS–STING activation correlates with improved survival and enhanced checkpoint blockade response in cancer
- Molecular markers may improve risk assessment in oral potentially malignant disorders
- Vaginal irrigation self-management shows conditional support for cervical cancer patients undergoing radiotherapy
- Liquid biopsy guides kidney-sparing decisions in upper tract urothelial carcinoma without replacing standard care
- Glycolysis-centered understanding of ovarian cancer may support biomarker-guided combination strategies and improve translational therapeutic design
- Systemic cancer treatment linked to 5% skeletal muscle loss over 90 days
- Darolutamide plus ADT and docetaxel reduces death risk 37% in metastatic hormone-sensitive prostate cancer
- TIL therapy and engineered viral vector immunotherapies show pooled ORR of 37.8% in advanced melanoma
- Digital health tools may ease anxiety and depression in colorectal cancer patients
- FAM13A variants influence tissue destruction in COPD and fibrotic remodeling in pulmonary fibrosis
- Prediction models for postoperative atrial fibrillation in lung cancer surgery show moderate discriminative performance
- Nivolumab monotherapy yielded 12-month progression-free survival in metastatic anaplastic thyroid cancer
- T cell-based therapies show promise but face barriers in solid tumors
- Follicular T cell subsets and tertiary lymphoid structures may guide immunotherapy in ovarian cancer
- Tertiary lymphoid structures represent a promising but context-dependent biomarker and potential therapeutic intermediate in breast cancer
- Adding docetaxel to ADT and RT cuts mortality in high-risk prostate cancer with normal testosterone
- Favorable adiposity, statins, vitamin D, dried fruit linked to lower ovarian cancer risk in MR meta-analysis
- Nature-based IVR reduces anxiety and distress in breast cancer patients with low certainty evidence
- PD-1/PD-L1 inhibitors plus chemotherapy improve survival in advanced endometrial cancer
- Radiotherapy and chemotherapy show no clear link to obstructive sleep apnea in head and neck cancer patients
- Aspiration pneumonia affects 74.8% of head and neck cancer patients after chemoradiotherapy
- Long-term data reveals cribriform-positive status drives metastatic risk in prostate cancer patients
- Systematic review shows robotic colorectal surgery lowers CRP and complications versus laparoscopy in adult patients
- Robotic TME reduces CRM positivity and three-year recurrence in mid or low rectal cancer
- Immunotherapy improves complete response but lacks overall response benefit in HR+ breast cancer
- Hepatologist-led palliative care matches specialist care for cirrhosis and cancer patients
- Fecal DNA testing improved colorectal cancer screening rates compared to immunochemical testing in primary care
- Fertility preservation in female leukemia patients carries risks of leukemic cell contamination and disease reintroduction
- Exercise interventions significantly reduced depressive symptoms in adults with lung and digestive cancer across eight randomized controlled trials
- Meta-analysis quantifies pre-diagnosis weight loss in pancreatic cancer patients
- Psychosocial interventions significantly reduce demoralization and depressive symptoms in patients with cancer
- Deep learning models for glioma segmentation achieve high whole tumor accuracy with DSC 0.860
- Regional lymphadenectomy improves survival in resectable gallbladder cancer: meta-analysis
- Extraperitoneal single-port robotic-assisted radical prostatectomy shortens console time by 83 minutes versus multiport transperitoneal approaches in 1997 patients
- Acupuncture, ACT, Nutrition Top Non-Drug Interventions for Lung Cancer
- Psychosocial interventions show no significant changes in suicidal behavior severity among cancer patients across nine randomized trials
- Trastuzumab deruxtecan improves PFS vs chemotherapy in HR-positive, HER2-low breast cancer
- Contrast-enhanced mammography shows 97% sensitivity for mammographic asymmetries in meta-analysis
- Lymphovenous anastomosis improves quality of life in breast cancer-related lymphedema
- Transitioning from static TNM staging to a multidimensional, adaptive treatment model integrating genomics and immunology for HPV-associated OPSCC
- Immune checkpoint inhibitors appear safe in cancer patients with pre-existing sarcoidosis
- CE-MRI rules out malignancy in 13.1% pretest probability for high-risk breast lesions with 91.3% sensitivity
- EHR-facilitated collaborative care intervention increased initial palliative care consults by 50% in metastatic cancer patients
- General obesity, central obesity, and high triglycerides increase risk of precancerous polyps in colorectal cancer surveillance
- Thiazolidinediones show lower hepatocellular carcinoma risk than DPP-4 inhibitors, GLP-1RAs, insulin, and sulfonylureas in this network meta-analysis
- Physical exercise improves cognitive function in patients with cancer, umbrella review finds
- Combining Pentraxin-3 and AFP increases sensitivity to 0.92 for hepatocellular carcinoma diagnosis in chronic liver disease
- Intensity-modulated radiotherapy reduces acute and delayed G2+GI toxicities versus 3D-CRT in high-risk prostate cancer
- MRI-based risk calculators improve discrimination for clinically significant and all prostate cancer compared to traditional models
- Micro-ultrasound sensitivity 0.84 and specificity 0.41 for prostate cancer in five prospective studies
- AI assistance improves diagnostic accuracy for clinically significant prostate cancer detection via MRI in this systematic review