Questions about Cancer
How does receptor discordance in metastatic breast cancer impact overall survival rates?
Receptor discordance in metastatic breast cancer is linked to worse overall survival, especially when hormone receptors are lost.
Full answer →What does a pilot study say about deep longitudinal profiling for metastatic cancer patients?
The provided sources do not contain any pilot study on deep longitudinal profiling for metastatic cancer patients.
Full answer →Does having different receptors in metastatic breast cancer lesions affect how long I live?
Yes, different receptor types in metastatic breast cancer lesions are linked to different survival times, with hormone receptor-positive subtypes generally having longer survival than HER2-positive or triple-negative subtypes.
Full answer →What immune checkpoint inhibitor is best for survival in metastatic cervical cancer?
Pembrolizumab plus chemotherapy is the best-supported immune checkpoint inhibitor for improving overall survival in metastatic cervical cancer, especially in PD-L1 positive patients.
Full answer →Does the neutrophil-to-lymphocyte ratio predict progression-free survival in metastatic cervical cancer patients?
A high neutrophil-to-lymphocyte ratio (NLR) before treatment predicts shorter progression-free survival in metastatic cervical cancer patients receiving immunotherapy, while a low ratio suggests better outcomes.
Full answer →How does the neutrophil-to-lymphocyte ratio predict survival in metastatic cervical cancer treated with immune therapy?
A lower neutrophil-to-lymphocyte ratio (NLR) before starting immune therapy predicts longer survival and better response rates in metastatic cervical cancer, while a higher ratio signals a worse outlook.
Full answer →What evidence exists for liver cancer alongside lung, breast, and kidney cancer?
Research shows liver cancer detection using liquid biopsies has high accuracy similar to lung, breast, and kidney cancers, while survival rates for liver cancer have improved significantly in recent years.
Full answer →Can machine learning with cfDNA help detect liver cancer at different stages?
Yes, machine learning with cfDNA can detect liver cancer at various stages, with sensitivities ranging from 44% for stage I to 99% for stage III and high specificity.
Full answer →All Cancer Articles
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- EBUS-TBNB yields higher diagnostic rates for lymphoma and sarcoidosis compared to EBUS-TBNA
- MRI Radiomics Predicts TERTp Mutation in Glioma with Moderate Accuracy
- Comprehensive palliative care improves quality of life, survival, and symptoms in thoracic cancer patients
- Signet ring morphology in gastric biopsies may mask metastatic invasive lobular carcinoma from breast cancer
- Long-read sequencing improves detection of structural variants and methylation patterns in liquid biopsy
- Multitarget designs and microenvironment remodeling may overcome resistance to CAR T-cell therapy in B-cell malignancies
- OTUD7B acts as a context-dependent regulator in various cancers and inflammatory conditions
- EMR integrated platform improves data abstraction efficiency and speed for cancer patient records
- Advanced experimental models and computational tools provide dynamic frameworks for understanding oral disease progression
- NODI parameters ODI and V-ISO differentiate gliomas from brain metastases in contrast-enhancing regions
- TRAM MRI shows 0.89 AUC for differentiating treatment response from radionecrosis in CNS tumors
- Tislelizumab plus chemotherapy improves survival in extensive-stage small cell lung cancer
- Artificial intelligence as a mechanistic microscope and digital twin in colorectal cancer faces generalizability and regulatory validation limitations
- E-health self-management interventions improve quality of life in cancer patients with a standardized mean difference of 0.18
- Screening and management strategies for stigma in patients with colorectal cancer and stomas require clinically meaningful guidance
- Diagnostic prediction models show moderate-to-good discrimination for cancer-related fatigue
- Low pretreatment lymphocyte-to-monocyte ratio linked to worse survival in cervical cancer
- Narrowband UVB remains first-line phototherapy for vitiligo, with JAK inhibitors emerging as adjuncts
- Conversion surgery after induction therapy improves 5-year survival to 26.5% versus 11.6% in cT4 esophageal cancer patients
- CDK4/6 inhibitors show therapeutic potential in advanced gastrointestinal cancers, review finds
- Mitochondria-targeted strategies show translational potential for improving radiosensitivity in radioresistant tumor cells
- Local radiopharmaceutical production reduces therapy costs by 93% to 96% across 54 African nations
- Angiogenesis inhibitors combined with chemotherapy improve progression-free survival in advanced breast cancer patients
- Lower baseline quality of life linked to 7% higher mortality risk in lung cancer patients
- Microbial metabolites may promote or suppress cancer progression through inflammation, DNA damage, or immune modulation
- Exercise-induced myokines show functional duality with tumor-suppressive or tumor-promoting effects depending on microenvironmental context
- Cadmium exposure linked to higher endometrial cancer risk, while PCBs show no association in meta-analysis
- Hypofractionated and dose-boosted radiotherapy improves metastasis-free survival in clinically localised prostate cancer
- Meta-analysis links baseline and dynamic ctDNA to survival in advanced NSCLC
- Datopotamab deruxtecan showed no overall survival benefit versus investigator's choice chemotherapy in metastatic HR-positive breast cancer.
- Lenvatinib plus PD-1 inhibitor improves survival versus bevacizumab plus PD-1 inhibitor in unresectable hepatocellular carcinoma
- Meta-analysis finds modest melanoma risk increase among infertile women using fertility treatments
- Combination immunotherapy and targeted therapy regimens show favorable survival outcomes versus monotherapies in unresectable hepatocellular carcinoma
- Network meta-analysis finds similar overall survival for three HCC regimens
- Low-intensity cervical screening shows similar CIN2+ risk to high-intensity screening in HPV-vaccinated women
- WBRT shows no significant survival benefit in thyroid cancer brain metastases meta-analysis
- Wearable monitoring reduced prolonged hospital stay from 24% to 7% in lung cancer surgery cohorts
- Metal-based nanomaterials show promise for cancer phototherapy in preclinical models
- Isoliquiritigenin shows significant anti-ovarian cancer effects with low toxicity as a promising natural candidate for targeted therapy
- TEAS significantly reduces overall PONV risk in patients undergoing breast surgery compared to sham stimulation or routine care
- Volume doubling time under 200 days marks all malignant nodules in 27 studies of lung cancer screening programs
- Ultrasound-driven mechanical immunomodulation shows promise for tumor therapy but faces key hurdles
- Rate of drug concentration rise alters hemodynamic responses and mortality risk in coronary heart disease patients
- Meta-analysis finds rheumatoid arthritis associated with increased thyroid cancer risk in pooled cohort data
- Combination therapy with 3M-052 and anti-TNFR2 antibody suppressed colon cancer growth in mouse models while enhancing immune response
- Cetuximab maintenance therapy prolongs progression-free survival and overall survival versus observation in metastatic colorectal cancer
- Molecularly engineered BODIPY photosensitizers combined with immunotherapeutic strategies show potential for cancer treatment
- Statins reduce recurrence risk 23% and mortality in 267,913 HR+ breast cancer patients with HR 0.77
- cGAS–STING activation correlates with improved survival and enhanced checkpoint blockade response in cancer
- Molecular markers may improve risk assessment in oral potentially malignant disorders
- Vaginal irrigation self-management shows conditional support for cervical cancer patients undergoing radiotherapy
- Liquid biopsy guides kidney-sparing decisions in upper tract urothelial carcinoma without replacing standard care
- Glycolysis-centered understanding of ovarian cancer may support biomarker-guided combination strategies and improve translational therapeutic design
- Systemic cancer treatment linked to 5% skeletal muscle loss over 90 days
- Darolutamide plus ADT and docetaxel reduces death risk 37% in metastatic hormone-sensitive prostate cancer
- TIL therapy and engineered viral vector immunotherapies show pooled ORR of 37.8% in advanced melanoma
- Digital health tools may ease anxiety and depression in colorectal cancer patients
- FAM13A variants influence tissue destruction in COPD and fibrotic remodeling in pulmonary fibrosis
- Prediction models for postoperative atrial fibrillation in lung cancer surgery show moderate discriminative performance
- Nivolumab monotherapy yielded 12-month progression-free survival in metastatic anaplastic thyroid cancer
- T cell-based therapies show promise but face barriers in solid tumors
- Follicular T cell subsets and tertiary lymphoid structures may guide immunotherapy in ovarian cancer
- Tertiary lymphoid structures represent a promising but context-dependent biomarker and potential therapeutic intermediate in breast cancer
- Adding docetaxel to ADT and RT cuts mortality in high-risk prostate cancer with normal testosterone
- Favorable adiposity, statins, vitamin D, dried fruit linked to lower ovarian cancer risk in MR meta-analysis
- Nature-based IVR reduces anxiety and distress in breast cancer patients with low certainty evidence
- PD-1/PD-L1 inhibitors plus chemotherapy improve survival in advanced endometrial cancer
- Radiotherapy and chemotherapy show no clear link to obstructive sleep apnea in head and neck cancer patients
- Aspiration pneumonia affects 74.8% of head and neck cancer patients after chemoradiotherapy
- Long-term data reveals cribriform-positive status drives metastatic risk in prostate cancer patients
- Systematic review shows robotic colorectal surgery lowers CRP and complications versus laparoscopy in adult patients
- Robotic TME reduces CRM positivity and three-year recurrence in mid or low rectal cancer
- Immunotherapy improves complete response but lacks overall response benefit in HR+ breast cancer
- Hepatologist-led palliative care matches specialist care for cirrhosis and cancer patients
- Fecal DNA testing improved colorectal cancer screening rates compared to immunochemical testing in primary care
- Fertility preservation in female leukemia patients carries risks of leukemic cell contamination and disease reintroduction
- Exercise interventions significantly reduced depressive symptoms in adults with lung and digestive cancer across eight randomized controlled trials
- Meta-analysis quantifies pre-diagnosis weight loss in pancreatic cancer patients
- Psychosocial interventions significantly reduce demoralization and depressive symptoms in patients with cancer
- Deep learning models for glioma segmentation achieve high whole tumor accuracy with DSC 0.860
- Regional lymphadenectomy improves survival in resectable gallbladder cancer: meta-analysis
- Extraperitoneal single-port robotic-assisted radical prostatectomy shortens console time by 83 minutes versus multiport transperitoneal approaches in 1997 patients
- Acupuncture, ACT, Nutrition Top Non-Drug Interventions for Lung Cancer
- Psychosocial interventions show no significant changes in suicidal behavior severity among cancer patients across nine randomized trials
- Trastuzumab deruxtecan improves PFS vs chemotherapy in HR-positive, HER2-low breast cancer
- Contrast-enhanced mammography shows 97% sensitivity for mammographic asymmetries in meta-analysis
- Lymphovenous anastomosis improves quality of life in breast cancer-related lymphedema
- Transitioning from static TNM staging to a multidimensional, adaptive treatment model integrating genomics and immunology for HPV-associated OPSCC
- Immune checkpoint inhibitors appear safe in cancer patients with pre-existing sarcoidosis
- CE-MRI rules out malignancy in 13.1% pretest probability for high-risk breast lesions with 91.3% sensitivity
- EHR-facilitated collaborative care intervention increased initial palliative care consults by 50% in metastatic cancer patients
- General obesity, central obesity, and high triglycerides increase risk of precancerous polyps in colorectal cancer surveillance
- Physical exercise improves cognitive function in patients with cancer, umbrella review finds
- Combining Pentraxin-3 and AFP increases sensitivity to 0.92 for hepatocellular carcinoma diagnosis in chronic liver disease
- Intensity-modulated radiotherapy reduces acute and delayed G2+GI toxicities versus 3D-CRT in high-risk prostate cancer
- MRI-based risk calculators improve discrimination for clinically significant and all prostate cancer compared to traditional models
- Micro-ultrasound sensitivity 0.84 and specificity 0.41 for prostate cancer in five prospective studies
- AI assistance improves diagnostic accuracy for clinically significant prostate cancer detection via MRI in this systematic review
- Local anaesthetic transperineal biopsy reduces infection and sepsis while improving cancer detection compared to transrectal ultrasonography methods
- 64 Cu-PSMA-617 shows highest detection rates in biochemically recurrent prostate cancer
- Metachronous non-muscle invasive bladder cancer after UTUC has worse recurrence and progression with BCG than primary disease
- TAC chemotherapy improves relapse-free survival in certain early breast cancer subtypes
- FAPI PET shows higher sensitivity and specificity than FDG for cervical cancer diagnosis
- Adjuvant radiotherapy improves recurrence-free survival for intermediate-risk cervical cancer patients after surgery
- Meta-analysis finds higher complication rates with immediate versus delayed breast reconstruction
- Blood-based ctDNA tests show low sensitivity for advanced colorectal neoplasia in asymptomatic adults
- Chemoimmunotherapy improves survival in solid tumors regardless of liver metastasis status
- Persistent ymrEMVI and ymrTD on post-neoadjuvant MRI predict inferior disease-free and overall survival in rectal cancer patients
- Tumor Treating Fields may disrupt tumor communication and induce conditional BRCAness in malignant pleural mesothelioma
- Geriatric assessment integration is key for equitable cancer care in aging Morocco
- 27648 patients shows robotic TME improves specimen quality and margin safety for rectal cancer cases
- Carer psychological distress linked to worse patient mental health and higher service use in cancer care
- Physical activity guidance for pregnancy after cancer is sparse and siloed, scoping review finds
- Nanomedicine strategies show promise for targeting pancreatic ductal adenocarcinoma
- Cadonilimab plus chemotherapy improves objective response rate to 0.62 in solid tumor patients
- Weight reduction ranked highest for limb volume, while VR-based training ranked highest for pain in breast cancer-related lymphedema
- Minimally invasive cystectomy reduces blood loss and transfusions but extends operative time
- AI technologies for immunotherapy optimization face data quality and safety concerns hindering routine clinical adoption
- TLS manipulation and immunotherapy in pancreatic cancer face significant mechanistic and regulatory uncertainties
- X chromosome inactivation escape and skewing are discussed in a narrative review covering autoimmune, neurodevelopmental, cardiovascular, and cancer conditions
- Gut microbiome metabolites regulate bone health via SCFAs, bile acids, and tryptophan pathways
- CD38+ NK cells may link disrupted immune tolerance in rheumatoid arthritis and colorectal cancer
- Stimulus-responsive sonodynamic immunotherapy shows promise in preclinical cancer models
- Microbiome and metabolite markers may enhance colorectal cancer detection and therapeutic guidance strategies
- Gut microbiota and metabolites may influence autoimmune thyroid disease, thyroid dysfunction, and thyroid cancer
- Narrative review discusses LPA signaling in advanced prostate cancer
- Network meta-analysis ranks nonpharmacological dyspnoea strategies in lung cancer
- Scoping review of AI for head and neck cancer risk stratification
- Narrative review links gut microbial metabolites to colorectal cancer mechanisms
- Narrative review examines microorganisms in breast cancer with limited evidence from cross-sectional studies and models
- Narrative review explores HNRNPA2B1 as a possible regulator of RNA fate in cancer
- Narrative review on KMT2C alterations in gastrointestinal cancers and therapeutic implications
- Narrative review on PCSK9 inhibitors for familial hypercholesterolemia
- Review of T cell engagers highlights potential for treating solid tumors and small cell lung cancer cases
- Multicomponent intervention with mailed FIT and navigation increased colorectal cancer screening uptake in Federally Qualified Health Centers
- Review of BsAb-armed T cells for solid tumors and CAR-T and BsAb therapy
- Systematic review and meta-analysis of proximal tibia reconstruction after tumor resection reports complication and survival rates
- Systematic Review: Intercellular Mitochondrial Transfer in Melanoma Progression and Resistance
- Systematic review and meta-analysis shows dermoscopy-guided excision reduces incomplete excision in keratinocyte cancer
- Case report and review of duodenal malignant glomus tumor with novel molecular variants
- Narrative review explores AI-assisted radiotherapy for pelvic and abdominal cancers in Africa
- Narrative review discusses inflammaging and immunosenescence in older adults with colorectal cancer
- Systematic review and meta-analysis of TRBC1 flow cytometry for mature T-cell neoplasms
- Meta-analysis finds germline LTS and somatic TERT variants are mutually exclusive in thyroid cancer and melanoma
- Systematic review and meta-analysis of n-3 PUFAs for pancreatic cancer patients
- Review of natural products in preclinical cancer models notes methodological variability and bioavailability differences
- Case report review of acupuncture for chemotherapy-induced peripheral neuropathy in a patient with lung cancer and bone metastasis
- Narrative review of fertility preservation techniques for women with malignant tumors in China
- Meta-analysis shows immune checkpoint inhibitor combinations improve survival and response rates in advanced cervical cancer patients with manageable safety profiles
- Review explores host-microbiome interactions in breast cancer
- Case report details multimodal treatment for aggressive thyroid carcinoma
- Systematic review shows robot-assisted minimally invasive esophagectomy reduces blood loss and hospital stay compared to conventional minimally invasive approaches for resectable esophageal cancer cases involving adult patients
- Case report review highlights suspicion of breast cancer metastasis to thyroid in a 54-year-old woman
- Review: Targeting mRNA Processing Enhances Immune Checkpoint Blockade in Cancer
- Overweight and obesity linked to increased bladder cancer risk in males in meta-analysis
- Network meta-analysis suggests immune checkpoint inhibitor regimens improve survival in advanced gastric cancer compared to chemotherapy alone
- Guideline-based case report: neoadjuvant alectinib in ALK-rearranged stage IIIB lung cancer
- Review discusses pharmacogenomic biomarkers for pediatric B-ALL chemotherapy dosing
- Narrative review suggests idiotype-directed CAAR-T therapy remains hypothetical for B-cell malignancies
- Systematic review and meta-analysis on pre-diagnostic weight loss in pancreatic cancer
- Narrative review discusses SECTM1 for cancer, cardiovascular disorders, and neurodegenerative diseases without reported outcomes or safety data
- Healthcare professionals need updated guidance on managing breast cancer-related lymphedema effectively today
- Narrative review discusses CMTM4 role in cancer tumor immune microenvironment with noted translational challenges
- Meta-analysis finds robotic low anterior resection improves outcomes in younger rectal cancer patients
- Palliative care consultation for bone metastases radiotherapy patients shows no outcome data in protocol
- PD-1/PD-L1 inhibitors improve response in dMMR/MSI-H metastatic colorectal cancer
- Case report on VMAT radiotherapy for inoperable anal Buschke-Lowenstein tumors
- Review of AI models shows high accuracy for ovarian cancer diagnosis and outcome prediction
- Systematic review and meta-analysis links benzene exposure to increased lymphoid neoplasm risk
- Robotic ISR shows better anal function and fewer complications than laparoscopic approach
- Meta-analysis of double-expressor lymphoma prognoses and novel therapies
- Case report of YL205 antibody-drug conjugate in platinum-resistant ovarian carcinoma
- Systematic review of preclinical CBD effects in canine cancers
- Unplanned Healthcare Encounters Common in Pediatric Cancer
- Meta-analysis links CD40 rs1883832 polymorphism to breast cancer susceptibility
- Systematic Review Maps Exponential Growth of Antibody-Drug Conjugate Trials in Lung Cancer
- Meta-analysis shows bevacizumab plus FOLFOX improves response rates without increasing common toxicities in advanced colorectal cancer
- Narrative review covers diagnostic and treatment strategies for metastatic head and neck cancer with no identifiable primary tumor
- Narrative Review Explores Alistipes Genus Role in Inflammatory and Cancers
- Narrative review discusses colorectal cancer metastasis patterns with immune checkpoint inhibitors and targeted therapies
- Molecular review explores Siglec signaling pathways in cancer and inflammatory disorders
- Narrative review explores bromelain's potential across multiple chronic diseases
- Narrative review outlines multimodal decision-making for EGFR-mutant NSCLC with leptomeningeal metastasis
- Systematic review and meta-analysis of AI for melanoma risk assessment in pigmented skin lesions
- Systematic review and meta-analysis of DDS-based chemotherapy in murine colon cancer models
- Narrative review on Chinese medicine monomers for gastric cancer mechanisms
- Narrative review of aberrant RBBP6 expression across seven solid tumor types
- Review synthesizes potential uses of Fritillariae Cirrhosae Bulbus alkaloids for various conditions
- Postoperative VTE prediction models show substantial heterogeneity and high bias risk in lung cancer surgery patients undergoing systematic review analysis
- Systematic review of immune checkpoint inhibitors in cancer efficacy and safety
- Narrative review discusses AI-driven pathology models for esophageal cancer and Barrett's esophagus management
- Systematic review explores metabolic-immune axis in glioma progression and resistance
- Evidence mapping review on nutritional prehabilitation for head and neck cancer patients
- Tucidinostat plus R-CHOP improves outcomes in MYC/BCL2 double-expressor DLBCL
- Meta-analysis reveals complex links between endocrine therapy and fertility worries in cancer patients of childbearing age
- Meta-analysis shows PET/CT alters management in one of five adults with abdominal malignancies
- Narrative review discusses extracellular vesicles as biomarkers for cancer, neurological disorders, and cardiovascular diseases
- Meta-analysis finds survivorship programs improve quality of life in colorectal cancer survivors