Questions about Cancer
How does receptor discordance in metastatic breast cancer impact overall survival rates?
Receptor discordance in metastatic breast cancer is linked to worse overall survival, especially when hormone receptors are lost.
Full answer →What does a pilot study say about deep longitudinal profiling for metastatic cancer patients?
The provided sources do not contain any pilot study on deep longitudinal profiling for metastatic cancer patients.
Full answer →Does having different receptors in metastatic breast cancer lesions affect how long I live?
Yes, different receptor types in metastatic breast cancer lesions are linked to different survival times, with hormone receptor-positive subtypes generally having longer survival than HER2-positive or triple-negative subtypes.
Full answer →What immune checkpoint inhibitor is best for survival in metastatic cervical cancer?
Pembrolizumab plus chemotherapy is the best-supported immune checkpoint inhibitor for improving overall survival in metastatic cervical cancer, especially in PD-L1 positive patients.
Full answer →Does the neutrophil-to-lymphocyte ratio predict progression-free survival in metastatic cervical cancer patients?
A high neutrophil-to-lymphocyte ratio (NLR) before treatment predicts shorter progression-free survival in metastatic cervical cancer patients receiving immunotherapy, while a low ratio suggests better outcomes.
Full answer →How does the neutrophil-to-lymphocyte ratio predict survival in metastatic cervical cancer treated with immune therapy?
A lower neutrophil-to-lymphocyte ratio (NLR) before starting immune therapy predicts longer survival and better response rates in metastatic cervical cancer, while a higher ratio signals a worse outlook.
Full answer →What evidence exists for liver cancer alongside lung, breast, and kidney cancer?
Research shows liver cancer detection using liquid biopsies has high accuracy similar to lung, breast, and kidney cancers, while survival rates for liver cancer have improved significantly in recent years.
Full answer →Can machine learning with cfDNA help detect liver cancer at different stages?
Yes, machine learning with cfDNA can detect liver cancer at various stages, with sensitivities ranging from 44% for stage I to 99% for stage III and high specificity.
Full answer →All Cancer Articles
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- Exosomal miRNAs Show High Diagnostic Accuracy for Hepatocellular Carcinoma
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- GPX4-targeted chemical strategies present bidirectional roles and specific translational barriers in multiple disease states
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- Hamburg Life After Cancer Program protocol aims to improve quality of life in cancer survivors
- Rezvilutamide plus ADT with efavirenz-based ART yields PSA decline in one HIV-positive mHSPC patient
- Spatial immune-ecology framework proposed for gastric and GEJ adenocarcinoma ICI selection
- FDA-approved AI solutions for cancer histopathology are limited to a narrow range of applications
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- Postoperative conventional fractionation radiotherapy is more cost-effective than preoperative accelerated fractionation for oral cavity cancer
- Radiation therapy and nasopharyngeal cancer significantly increase risk of chronic rhinosinusitis in head and neck cancer patients
- Egg consumption associated with reduced glioma risk in Eastern populations and increased head and neck cancer risk
- Quercetin immunity research surges, mapping review finds 12 thematic clusters
- Four mailer types aim to increase health care proxy documentation in patients with chronic conditions
- Splenic hilum nodal involvement is rare in pancreatic body adenocarcinoma with a 1.1% prevalence
- MRI-based radiomics models achieve 0.91 AUC for predicting GPC3 expression in hepatocellular carcinoma
- Nurse-coordinated monitoring of biomarkers and symptoms supports clinical assessment for immune checkpoint inhibitor safety
- Gut microbiome composition correlates with clinical outcomes in hepatocellular carcinoma patients treated with immune checkpoint inhibitors
- Encorafenib and Binimetinib Combination Therapy for Patients with BRAF Mutated Cutaneous Melanoma
- Triple Combination Therapy Improves Progression-Free Survival in Patients with Hepatocellular Carcinoma
- Empowered Survivor digital tool boosts self-efficacy in oral cancer survivors
- Play interventions significantly reduce anxiety and depressive symptoms in children with cancer
- Most oncology professionals lack prior training in integrative medicine despite emerging curriculum needs
- Bidirectional crosstalk between hepatic stellate cell-derived CAFs and T cells drives immune evasion in HCC
- Meridian Sinew Tuina significantly reduces upper limb circumference and pain in breast cancer-related lymphedema
- Objective response rate correlates with overall survival in nivolumab-containing regimens for metastatic melanoma
- Bispecific antibodies improve progression-free survival and overall survival in patients with solid tumors
- Higher pretreatment HALP score is associated with improved overall survival in head and neck cancer
- Multiparametric MRI and image-guided neurointerventions provide critical roles in brain tumor management and surveillance
- Delayed margin formation in lung tumor microwave ablation may occur despite lack of immediate intraprocedural margin
- Mitophagy acts as a core barrier to effective immunotherapy in melanoma and other skin cancers
- Radioactive iodine does not significantly reduce recurrence in low-risk differentiated thyroid cancer
- eREACH digital intervention meets non-inferiority for genetic service uptake and anxiety in cancer patients
- Machine learning predicts Ki-67 in renal tumors with moderate accuracy, AUC 0.85 to 0.86
- C3-derived skeletal muscle index shows strong correlation with L3 index in head and neck cancer
- CLDN18.2 expression prevalence of 33.99% in patients with gastric and gastroesophageal junction adenocarcinoma
- Post-translational modifications drive drug resistance in hepatocellular carcinoma, systematic review finds
- Cold atmospheric plasma modulates immune signaling pathways and macrophage polarization in infection and cancer models
- Docetaxel and PARPi additions to ARPI and ADT improve progression-free survival in mHSPC
- Disitamab vedotin and tislelizumab combination achieved remission of skin metastasis in a patient with bladder carcinoma
- High Siglec-15 Tumor Expression Tied to Worse Survival
- Bispecific antibodies improve progression-free survival and overall survival in patients with solid tumors
- Age and sex drive distinct immune microenvironment and evasion mechanisms in cancer patients
- High CAR-HEMATOTOX scores correlate with increased ICAHT odds and worse survival in CAR T-cell therapy
- Approximately 61% of cancer patients resume anticancer treatment after unplanned ICU admission
- Machine learning models predict cancer symptoms with AUC values ranging from 0.76 to 0.86
- Local therapies for liver, lung, and locoregional recurrence improve survival in pancreatic ductal adenocarcinoma
- Digital CBTi reduces insomnia severity scores more than telephone or group delivery methods
- Multidisciplinary Palliative Rehabilitation Improves Quality of Life in Advanced Life Limiting Illness
- Prevotella exhibits dual pro-tumorigenic and anti-tumorigenic roles in gastrointestinal cancer progression
- Oral frailty affects 52% of cancer patients, meta-analysis finds
- Metabolic risk factors including diabetes and metabolic syndrome are associated with increased hepatocellular carcinoma risk
- Malnutrition and sarcopenia are associated with poorer treatment tolerance and higher toxicity in head and neck cancer
- Splicing-derived neoantigens provide diverse target classes for T-cell and antibody-based cancer immunotherapies
- Bioactive compounds from aromatic plants show potent cytotoxic activities in various preclinical cancer models
- Long-term surveillance and endoscopic screening are critical for patients with synchronous multifocal early gastric cancer
- E3 ubiquitin ligases regulate DNA repair and promote resistance in gastrointestinal malignancies
- MULTIPL biomarker identifies patients with significantly longer overall survival on gemcitabine plus nab-paclitaxel
- Removal of phosphaturic mesenchymal tumors corrects biochemical aberrations in tumor-induced osteomalacia
- Deep Learning algorithms demonstrate potential for diagnosing oral potentially malignant disorders and squamous cell carcinoma
- Radiomic Features Demonstrate High Diagnostic Accuracy for Predicting Ki-67 Expression in Hepatocellular Carcinoma
- KRAS G12C inhibitors may remodel immunosuppressive tumor microenvironments into immunostimulatory states in KRAS-mutant tumors
- Phytochemicals modulate miRNA-mediated regulatory networks to influence metabolic reprogramming and cancer-associated signaling
- Multimodal AI and machine learning integration improves risk prediction and prognostic modeling in cancer management
- Single-port robot-assisted partial nephrectomy reduces estimated blood loss by 16.62 mL compared to multi-port
- Sulforaphane may modulate tumor suppressor genes and reduce Ki-67 proliferation index in specific cohorts
- Linalool exhibits cytotoxic and pro-apoptotic effects in vitro but lacks established clinical anticancer efficacy
- Stathmin implicated in cancer and non-neoplastic diseases, potential biomarker and therapeutic target
- PGE2 signaling via EP receptors drives tumor progression and context-dependent neuroinflammation in various diseases
- IL-17 axis targeting shows substantial efficacy but faces cost and delivery hurdles
- Acute cGAS-STING pathway activation may suppress tumors while chronic activation promotes progression
- mRNA vaccines offer a flexible and rapid production platform for personalized melanoma immunotherapy
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- PD-L1 expression shows potential utility in predicting malignant transformation risk in oral potentially malignant disorders
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- Adjunctive hemostatic agents in partial nephrectomy show no transfusion benefit
- High NLRP-3 Expression Linked to Poor Survival in Solid Cancers
- Allostatic load serves as a predictor of surgical outcomes and explains socioeconomic disparities
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- Engineered nanobodies offer programmable platform to overcome limitations of conventional antibodies in angiogenic diseases
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- Integrated Prognostic Criteria Improve Survival Stratification in Metastatic Castration-Sensitive Prostate Cancer
- Elevated inflammation-immunity-nutrition score linked to 2.13-fold higher mortality risk in cancer
- Pembrolizumab plus chemotherapy improves ORR and OS in HER2-negative advanced gastric or gastroesophageal junction cancer
- Multidimensional artificial intelligence decision support may improve precision and individualization in endoscopic submucosal dissection for early gastric cancer
- Lead-in ADT reduces grade ≥3 neutropenia incidence in metastatic hormone-sensitive prostate cancer patients
- PD-1 and PD-L1 inhibitors increase the risk of skin rash in cancer patients
- Cuba maintains a solid normative basis for pediatric palliative care despite identified gaps in training
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- Wasting is associated with higher chemotherapy toxicity and reduced survival in pediatric cancer patients
- Mucocutaneous manifestations serve as diagnostic indicators for various systemic diseases and paraneoplastic syndromes
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- Surfactant protein D serves as a prognostic marker and potential therapeutic agent in various cancers
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- Immune checkpoint inhibitors show limited activity in unselected pancreatic ductal adenocarcinoma without specific biomarkers
- Clinician-guided action plans and lifestyle coaching aim to improve sedentary time in childhood cancer survivors
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- Anti-CD6 monoclonal antibodies increase lymphocyte cytotoxicity against various human cancer cells in experimental systems
- Immune Health Index serves as a protective prognostic factor in post-resection hepatocellular carcinoma
- Cognitive Behavioral Therapy for Insomnia research highlights digital delivery and management of comorbid conditions
- Multi-parameter models of inhibitory receptor states could better predict immunotherapy response and toxicity
- Virtual reality significantly reduces pain, fear, and anxiety in pediatric patients during needle procedures
- Deep learning for leukemia diagnosis faces fragmented research and limited multimodal integration in current literature
- Natural polysaccharides combined with immune checkpoint inhibitors show synergistic benefits in preclinical and early clinical observations
- CircRNAs act as signaling hubs for immune checkpoints and indicators of ICI response in lymphoma
- Mediterranean diet adherence is associated with reduced risk of several site-specific cancers and mortality
- NRF2 signaling promotes tumor cell survival and multidrug resistance in advanced hepatocellular carcinoma
- Pretreatment Creatinine to Cystatin C Ratio Predicts Survival in Gastrointestinal Cancers
- Sarcopenia is associated with poorer survival and higher complication rates across multiple cancer types
- Structured nutrition education addresses barriers to dietary self-management and literacy in cancer survivors
- Viral mimicry induction via epigenetic therapies and DNA damage may convert cold tumors to hot
- Immunotherapy regimens for TKI-resistant NSCLC are not cost-effective without significant price reductions
- Aberrant IgG glycosylation correlates with cancer progression and serves as a novel aging-associated factor
- Occupational exposure to asbestos-free talc does not support increased risk of lung or laryngeal cancers
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- Elevated serum ferritin is associated with increased mortality risk in patients with malignant tumors
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- Durvalumab plus tremelimumab median PFS was 5.4 months in HIMALAYA eligible patients
- Postoperative food allergen exposure may impede wound healing through inflammatory responses and delayed angiogenesis
- TET2 functions as a tumor suppressor in myeloid malignancies and immunomodulator in solid tumors
- Fecal microbiota transplantation may modulate tumor microenvironment and enhance immunotherapy responses in several cancers
- Prolonged conservative treatment yields 58% complete response in endometrial hyperplasia and carcinoma
- Mosunetuzumab plus polatuzumab vedotin achieved a 100% overall response rate in Japanese patients with LBCL
- Pregnancy-associated melanoma does not independently worsen overall survival when stage is adequately controlled
- Reactive oxygen species promote tumorigenic programs and platinum-based chemotherapy resistance in high-grade serous ovarian cancer
- Multidisciplinary team management reduces mortality risk in patients with hepatobiliary and pancreatic malignancies
- CD73-adenosine axis serves as a metabolic immune checkpoint and potential target to overcome melanoma resistance
- Biochemical marker decline may not indicate clinical stability in intracranial growing teratoma syndrome
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- Preoperative inflammatory biomarkers SIRI and NLR associate with worse survival in UTUC after RNU
- Financial toxicity and food insecurity create a health-economic pathway impacting nutrition in women with cancer
- Metabolic reprogramming and plasticity drive tumor progression and resistance through interconnected transcription factors and enzymes
- AI-assisted clinicians achieve 1.000 sensitivity in melanoma diagnosis but autonomous AI lacks clear clinical advantage
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- Acidic microenvironments reprogram immune cells via pH sensors, driving tissue injury
- CAR T-cell therapies targeting specific antigens show potential for treating pediatric CNS tumors
- Evaluating Bevacizumab Addition to Atezolizumab Carboplatin and Pemetrexed in Nonsquamous NSCLC
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- EGFR and TP53 mutations linked to worse survival in sinonasal squamous cell carcinoma
- Completion thyroidectomy follows total thyroidectomy for similar operative safety in differentiated thyroid cancer
- Zygomatic implants provide high survival rates for maxillary reconstruction in head and neck cancer patients
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- Diverse therapeutic approaches including immunotherapy are utilized for patients with occult squamous cell carcinoma
- Metabolic checkpoints like lactate and adenosine drive immune escape and resistance to checkpoint blockade
- Laryngeal obstruction as initial sign of MEN2B in two pediatric cases with RET mutations
- Natural products modulate non-apoptotic cell death to bypass apoptotic blockades in cancer
- Chinese herbal medicine research for cancer pain management shows steady growth in publication volume
- GLP-1 Receptor Agonists Associated with Reduced Cancer Risk in Patients with Type 2 Diabetes
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- T cell signaling and metabolic rewiring are critical for T cell engager efficacy in solid tumors
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- OTUD1 serves as a potential biomarker for tumor prognosis and cardiovascular disease progression
- Comparative Analysis of Robot Assisted and Laparoscopic Partial Nephrectomy for Renal Tumors
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- FTO-targeted strategies currently lack clinical evaluation and rely on preclinical evidence for cancer treatment
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- Elevated serum M2BPGi is associated with a 4.61 hazard ratio for hepatocellular carcinoma development
- Opsin 3 serves as a potential therapeutic target for melanoma and inflammatory skin diseases
- Problem-focused coping is moderately to strongly associated with benefit finding in adult cancer patients
- AI diagnostic tools show high accuracy but limited real-world validation in systematic review
- Image-guided RFA and MWA show comparable efficacy and safety for small to medium hepatocellular carcinoma
- Parasite-derived molecules exert both pro-tumour and anti-tumour effects in experimental cancer models
- Proposed CTS protocol aims to convert cold tumors to hot and improve immunotherapy response
- Zolbetuximab combined with chemotherapy improves progression-free survival and overall survival in CLDN18.2-expressing gastric cancers
- Scavenger receptor-guided and cathepsin B-triggered nanodelivery systems enable targeted macrophage remodeling for atherosclerosis and cancer
- Direct-acting antivirals achieve 89% sustained virologic response in patients with hepatocellular carcinoma and HCV
- Prophylactic PEG tube placement improves nutritional status and reduces hospitalizations for head and neck cancer patients
- Gut microbiome taxa and metabolites enhance immune checkpoint inhibitor efficacy and mitigate systemic toxicity
- LncRNA signatures predict ICI response and survival across cancers in systematic review
- Immune checkpoint inhibitors are associated with acute kidney injury and multi-organ immune-related adverse events
- Axicabtagene ciloleucel shows higher early response but greater toxicity than tisagenlecleucel in large B-cell lymphoma
- KRAS G12C inhibitors improve progression-free survival with HR 0.62 in KRASG12C-mutated solid tumors
- Hangeshashinto may reduce oral mucositis risk in chemotherapy patients (RR 0.86)
- TSH suppression therapy promotes tumor progression via G-protein signaling pathways in differentiated thyroid cancer
- Patients with cardiovascular diseases show measurable prevalence of active cancer across multiple conditions
- Synergistic Effects of Immune Checkpoint Inhibitors and Radiotherapy in Solid Tumor Management
- Actinic keratosis increases melanoma risk while alcohol consumption is associated with lower squamous cell carcinoma risk
- Percutaneous Cervical Cordotomy reduces pain and opioid consumption in patients with severe cancer pain
- Mandala painting and music therapies improve quality of life and psychological well-being in cancer survivors
- Sugar sweetened beverages and orange juice are associated with increased risk of several cancer types
- Antibiotic exposure is associated with an 18.7% higher risk of gastrointestinal cancers
- Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
- EGFR inhibitors show reproducible activity and manageable toxicity in locally advanced or metastatic anal squamous cell carcinoma