N/A N=42 Other

The Diurnal Rhythm in Natriuretic Peptide Levels

Natriuretic Peptides · Obesity · Nocturnal Blood Pressure

Bottom Line

View on ClinicalTrials.gov: NCT03834168 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2021

Primary outcome: Primary: Plasma MRproANP — 17.92; 15.51 pmol/l — p=0.003

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: standardized Study Diet (Other)
Age: Adult · 18+ yrs
Sex: Male
Sponsor: University of Alabama at Birmingham
Primary completion: Feb 2020

Outcome Measures

Outcome	Result	p-value
PRIMARY Plasma MRproANP	—	—
SECONDARY Acrophase Difference in Hours Between the MR-proANP and Systolic BP Rhythm	-0.7; -4.9	—

Summary

The purpose of the study to assess the diurnal rhythm in natriuretic peptide levels and its temporal relationship with nocturnal blood pressure in obese and African-American individuals as compared with lean and white individuals.

Eligibility Criteria

Inclusion Criteria

Age 18 to 40 years
Blood pressure less than 140/90
Body Mass Index between 18.5 to 25 kg/m2 (lean) or 30 to 45 kg/m2 (obese)
Self identified African-American or white individuals
Willingness to comply with the study diet
Provide informed consent

Exclusion Criteria

History of hypertension
History of cardiovascular, renal, or liver disease
Diabetes or use of glucose-lowering medications
Use of vasoactive or diuretic medications
Atrial fibrillation
Anemia (Hematocrit 3x upper limit of normal)
Current smokers
Regular users of non-steroid anti-inflammatory medications

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03834168). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.