N/A
Completed N=42
The Diurnal Rhythm in Natriuretic Peptide Levels
Natriuretic Peptides · Obesity · Nocturnal Blood Pressure
Source: ClinicalTrials.gov NCT03834168 ↗
Enrolled (actual)
42
Serious AEs
0.0%
Results posted
Aug 2021
Primary outcomePrimary: Plasma MRproANP — 17.92; 15.51 pmol/l — p=0.003
Summary
The purpose of the study to assess the diurnal rhythm in natriuretic peptide levels and its temporal relationship with nocturnal blood pressure in obese and African-American individuals as compared with lean and white individuals.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Plasma MRproANP |
— | — |
| SECONDARY Acrophase Difference in Hours Between the MR-proANP and Systolic BP Rhythm |
-0.7; -4.9 | — |
Eligibility Criteria
Inclusion Criteria
- Age 18 to 40 years
- Blood pressure less than 140/90
- Body Mass Index between 18.5 to 25 kg/m2 (lean) or 30 to 45 kg/m2 (obese)
- Self identified African-American or white individuals
- Willingness to comply with the study diet
- Provide informed consent
Exclusion Criteria
- History of hypertension
- History of cardiovascular, renal, or liver disease
- Diabetes or use of glucose-lowering medications
- Use of vasoactive or diuretic medications
- Atrial fibrillation
- Anemia (Hematocrit 3x upper limit of normal)
- Current smokers
- Regular users of non-steroid anti-inflammatory medications
Data sourced from ClinicalTrials.gov (NCT03834168). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.