Phase 3
N=875
Trial to Evaluate the Safety and Immunogenicity of a 20-Valent Pneumococcal Vaccine in Adults 65 Years of Age or Older With Prior Pneumococcal Vaccination
Pneumococcal Disease
Bottom Line
View on ClinicalTrials.gov: NCT03835975 ↗Enrolled (actual)
875
Serious AEs
1.6%
Results posted
Feb 2021
Primary outcome: Primary: Percentage of Participants With Local Reactions Within 10 Days After Vaccination — 7.9; 2.5; 8.6; 12.7 percentage of participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 3
- Interventions
- 13vPnC (Biological); PPSV23 (Biological); 20vPnC (Biological)
- Age
- Older Adult · 65+ yrs
- Sex
- All
- Sponsor
- Pfizer
- Primary completion
- Feb 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percentage of Participants With Local Reactions Within 10 Days After Vaccination |
7.9; 2.5; 8.6; 12.7; 4.8; 3.6 | — |
| PRIMARY Percentage of Participants With Systemic Events Within 7 Days After Vaccination |
0.8; 0; 0; 1.6; 0; 0.8 | — |
| PRIMARY Percentage of Participants With Adverse Events (AEs) Within 1 Month After Vaccination |
7.5; 9.0; 4.9; 11.0; 10.4 | — |
| PRIMARY Percentage of Participants With Serious Adverse Events (SAEs) Within 6 Months After Vaccination |
0.8; 1.6; 2.4; 1.6; 1.6 | — |
| PRIMARY Percentage of Participants With Newly Diagnosed Chronic Medical Conditions (NDCMCs) Within 6 Months After Vaccination |
2.0; 0.8; 2.8; 2.4; 4.0 | — |
| PRIMARY Pneumococcal Opsonophagocytic Activity (OPA) Geometric Mean Titers (GMTs) at 1 Month After Vaccination |
50.8; 115.3; 82.1; 31.1; 54.3; 39.3 | — |
| SECONDARY Pneumococcal OPA Geometric Mean Fold Rise (GMFR) From Before Vaccination to 1 Month After Vaccination |
2.2; 3.4; 2.0; 2.4; 3.5; 1.9 | — |
| SECONDARY Percentage of Participants With >=4-Fold Rise in Pneumococcal OPA Titers From Before Vaccination to 1 Month After Vaccination |
22.9; 40.3; 20.8; 29.6; 41.3; 18.5 | — |
| SECONDARY Percentage of Participants With Pneumococcal OPA Titers >=Lower Limit of Quantitation (LLOQ) at 1 Month After Vaccination |
65.4; 87.7; 77.5; 76.1; 90.5; 87.4 | — |
Summary
This Phase 3 will describe the safety and immunogenicity of a 20-valent pneumococcal conjugate vaccine formulation in adults 65 years of age or older with prior pneumococcal vaccination
Eligibility Criteria
Inclusion Criteria
- Male or female adults 65 years of age or greater.
- Adults determined by clinical assessment, including medical history and clinical judgment, to be eligible for the study, including adults with preexisting stable disease, defined as disease not requiring significant change in therapy in the previous 6 weeks or hospitalization for worsening disease within 12 weeks before receipt of investigational product.
- Female subject of nonchildbearing potential; male subject not able to father children or who is able to father children and willing to use a highly effective method of contraception.
- Male or female adults who meet 1 of the following:
- Vaccination with PPSV23 greater than or equal to 1 year and less than or equal to 5 years prior to vaccination in the study, and no prior 13vPnC vaccination (Cohort A).
- Vaccination with 13vPnC greater than or equal to 6 months prior to vaccination in the study, and no prior PPSV23 vaccination (Cohort B).
- Vaccination with 13vPnC followed by PPSV23 (PPSV23 vaccination greater than or equal to 1 year prior to vaccination in the study) (Cohort C).
Exclusion Criteria
- Serious chronic disorder including metastatic malignancy, severe chronic obstructive pulmonary disease (COPD) requiring supplemental oxygen, end-stage renal disease with or without dialysis, clinically unstable cardiac disease, or any other disorder that, in the investigator's opinion, excludes the subject from participating in the study.
- History of microbiologically proven invasive disease caused by S pneumoniae.
Data sourced from ClinicalTrials.gov (NCT03835975). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.