N/A Completed N=238

Multi-chip Meta-analysis of Parkinson's Disease for Clinical Validation of Small Samples of Key Genes in Disease

Parkinson's Disease

Source: ClinicalTrials.gov NCT03848455 ↗

Enrolled (actual)

238

Serious AEs

0.0%

Results posted

Jan 2020

Primary outcomePrimary: Parkinson's Key Gene — 1.502; 3.653; 0.916; 1.669 gene expression relative to GAPDH — p=<0.001

Summary

The research team used meta-analytical statistical methods to integrate the results of different research groups on Parkinson's disease, using meta-analysis to find key genes related to the pathogenesis and development of Parkinson's disease, and to make small clinical results. The verification of the sample, the internal mechanism of the pathogenesis of Parkinson's disease and provide guidance and reference for subsequent experimental research.

Outcome Measures

Outcome	Result	p-value
PRIMARY Parkinson's Key Gene	1.502; 3.653; 0.916; 1.669; 2.237; 2.320	<0.001 sig
PRIMARY Unified Parkinson's Disease Rating Scale 3.0（UPDRS 3.0）	61.352	—
PRIMARY Non-motor Symptom Scale (NMSS)	—	—

Eligibility Criteria

Inclusion Criteria

PD group：
Patients who meet the 2016 China Parkinson's diagnostic criteria and the 2015 International Parkinson's and Movement Disorders Association (MDS) Parkinson's disease diagnostic criteria
Newly diagnosed primary PD patients, diagnosed within 3-6 months
Informed consent to the study
Age > 18 older
Non-PD group:
Age, gender-matched PD group
Non-PD, non-PDS, non-neurological degenerative disease, patients without inflammatory disease and related family history
Informed consent to the study
Age > 18 older

Exclusion Criteria

Severe craniocerebral trauma patients
Disturbance of consciousness
Severe organic diseases, cerebral hemorrhage, cerebral thrombosis, severe coronary heart disease and lung disease, severe liver and kidney dysfunction, severe diabetes, severe hearing And visual impairment
History of severe brain tumors, encephalitis or brain surgery

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03848455). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.