N/A
Completed N=52
Kick Out Parkinson's Disease 2
Source: ClinicalTrials.gov NCT03882879 ↗Enrolled (actual)
52
Serious AEs
5.8%
Results posted
Apr 2024
Primary outcomePrimary: Change in Mobility as Measured by the Timed Up & Go (TUG) — 9.66; 9.19; 10.9; 10.03 seconds — p=0.64
Summary
The benefits of exercise for general health and well-being in older adults are well-established. Balance exercises such as tai chi and yoga, along with resistance training, can improve or maintain physical function in older adults and enhance muscle strength. Furthermore, aerobic activity is critical for maintaining and improving cardiovascular and functional health. Non-contact boxing has recently seen a surge in popularity among individuals with Parkinson's Disease (PD), with components of both aerobic and balance exercise. While participants anecdotally note improvements in stress and physical function, this has only been minimally studied. Therefore, we conducted a 10-week long pilot study of a structured karate exercise program. Among 15 participants, our pilot data highlights improvements in quality of life and high enthusiasm for the karate classes. Based on these promising results from the pilot, we are recruiting a larger, randomized group for the second phase of the karate intervention. The aim of this study is to test whether and to what degree a community-based karate class tailored for individuals with early- to middle-stage Parkinson's Disease (PD) 1) is feasible; 2) improves objective outcomes such as mobility and balance; 3) improves patient-reported outcomes compared with individuals given a standard exercise prescription for PD.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Mobility as Measured by the Timed Up & Go (TUG) |
9.66; 9.19; 10.9; 10.03 | 0.64 |
| SECONDARY Change in Overall Well-being as Measured by the Patient Global Impression of Change Scale (PGIC) |
5.47; 5.75 | 0.53 |
Eligibility Criteria
Inclusion Criteria
- Subjects will be those diagnosed with Parkinson's Disease by a treating healthcare provider; if the subject is seen at Rush University Medical Center, this will be verified via chart review. If the subject is seen elsewhere, he or she will be asked to have their a healthcare provider sign a form confirming the diagnosis of Parkinson's Disease and indicating that the subject can ambulate independently as of the most recent visit, to be sent back to the research coordinator for eligibility verification.
- English speaking
- Living within the Chicago area
- Subjects may be untreated for Parkinson's Disease, or may be taking any individual PD medication or combination thereof. Subjects may or may not have had Deep Brain Stimulation. Subjects may or may not be receiving physical or occupational therapy. Subjects will be encouraged to maintain their same medication regimen throughout the duration of the study, however if issues arise requiring medication changes, the subject will be prompted to indicate medication changes in the bimonthly online survey, and will not be disqualified from study participation.
Exclusion Criteria
- Subjects requiring an assistive device (cane, walker, wheelchair) or the assistance of another person in order to ambulate.
- Subjects with active psychosis or exhibiting symptoms of a severe psychiatric disorder.
- Subjects unable to commit to attending, or to travel to, two classes weekly for 6 months.
- Subjects previously participating in a karate or other martial arts program, including boxing programs for PD, in the past 30 days.
- Subjects with atypical parkinsonism, including Progressive Supranuclear Palsy, Multiple System Atrophy, Dementia with Lewy Bodies, Corticobasal Syndrome, drug-induced parkinsonism, vascular parkinsonism, or atypical parkinsonism not otherwise specified, according to the referring healthcare provider.
Data sourced from ClinicalTrials.gov (NCT03882879). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.