N/A
N=7
Sensory Afferents for Deep Pressure Sensation
Normal Physiology
Bottom Line
View on ClinicalTrials.gov: NCT03937778 ↗Enrolled (actual)
7
Serious AEs
0.0%
Results posted
Oct 2021
Primary outcome: Primary: Difference Between Arms in the Change of Pressure Intensity From Baseline to After Loss of A-beta Sensation — -25.0 Units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Deep pressure block (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
- Primary completion
- Nov 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Difference Between Arms in the Change of Pressure Intensity From Baseline to After Loss of A-beta Sensation |
-25.0 | — |
| SECONDARY Difference Between Arms in the Change of Pressure Pleasantness From Baseline to After Loss of A-beta Sensation |
-11.4 | — |
| SECONDARY Difference Between Arms in the Change of Brushing Intensity From Baseline to After Loss of A-beta Sensation |
-18.6 | — |
| SECONDARY Difference Between Arms in the Change of Brushing Pleasantness From Baseline to After Loss of A-beta Sensation |
-12.4 | — |
Summary
Background:
Much is known about how people perceive light touch, temperature, and pain. But less is known about how deep pressure is perceived. Deep pressure is an important part of many touch therapies, like massage therapy. Researchers want to learn more to help people with chronic pain and other disorders.
Objective:
To find out which sensory nerve fibers are involved in feeling the sensation of deep pressure.
Eligibility:
Healthy people ages 18 50 enrolled in study number 16-AT-0077
Design:
Participants will be screened under study number 16-AT-0077
Participants will have 1 visit that lasts about 2 hours.
Participants will have a brief medical interview. They will have a urine test.
Participants will have ischemic nerve block on 1 arm. A blood pressure cuff will be inflated until the arm is numb for up to an hour.
Participants will have tests to see how they perceive different sensations. They will rate gentle brushing on the hands and forearms. They will rate gentle pressure squeezing from a hand massager on the hands and forearms.
Participants will receive other sensations such as vibration, cool, warm, pinprick without piercing the skin, finger movement, and pressure. They will be asked to rate or respond to the sensations. They will be asked to rate any pain or discomfort from the nerve block on an ongoing basis.
Eligibility Criteria
- INCLUSION CRITERIA:
All subjects must be:
- Between 18 and 50 years old.
- Fluent in English.
- Able to provide written informed consent.
- Enrolled in 16-AT-0077, Clinical and Scientific Assessment of Pain and Painful Disorders
EXCLUSION CRITERIA
- Unable to comply with study procedures.
- Have used recreational drugs in the past 30 days.
- Pregnancy or breastfeeding.
- Congenital upper limb deficiency or amputation.
- Peripheral neuropathy, dermatological condition such as scars or burns, or has had a tattoo in the testing region within the previous four weeks that might influence cutaneous sensibility.
- Current chronic pain condition or has had chronic pain in the past year (painful condition lasting more than six months), including ongoing treatment with medications for neuropathic pain (e.g. gabapentin, tricyclic antidepressants, pregabalin, tramadol).
- Major medical condition, such as kidney, liver, cardiovascular (including blood clots, hypertension, preexisting cardiac arrhythmia, lymphadenopathy), autonomic, pulmonary, or neurological problems (e.g., seizure disorder) or a chronic systemic disease (e.g., diabetes) or Raynaud s disease.
- Personal history or first-degree family history of blood clots or clotting and circulatory disorders
- History of a seizures or first-degree family member with a seizure disorder
- High (>140/90) or low (<90/60) blood pressure
- Current and untreated diagnosis of major depression, post-traumatic stress syndrome, bipolar disorder, psychosis, anxiety or panic disorder, alcohol or substance use disorders
- History of fainting with blood draws
- Any medical counter-indications to the nerve blocks.
- Participant s arm unable to fit in inflated arm blood pressure cuff
- Participant has taken any pain medication other than an over-the-counter NSAIDs or acetaminophen within the last month or for more than one month on a continual basis within last six months.
- Used topical pain-relieving creams in the testing area within 24 hours of testing or non-steroidal anti-inflammatory drugs (NSAIDS), (e.g. aspirin, ibuprofen, acetaminophen, or naproxen) within 3 days of testing
- Recent use of medications that increase risk of seizures (e.g. antidepressant Wellbutrin or antipsychotic Haldol)
- NIH employees who are subordinates, relatives, or co-workers of the investigators, or NCCIH DIR employees.
EXCLUSION CRITERIA FOR INDIVIDUAL STUDY SESSION:
- Shows signs of alcohol withdrawal syndrome, or has behavioral signs of intoxication: will be excluded immediately and not have the possibility to reschedule their session.
- Used topical pain-relieving creams in the testing area (e.g. methylsalicylate, capsaicin) within 24 hours of testing or used non-steroidal anti-inflammatory drugs (NSAIDS, e.g. aspirin, ibuprofen), acetaminophen, or naproxen within 3 days of testing.
Data sourced from ClinicalTrials.gov (NCT03937778). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.