Phase 2 N=49 Normal Breathing and Swallowing in Healthy Volunteers
Healthy
Primary: Reflexive Cough Testing (With Urge-to-Cough) — 3; 5 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=40 Physiologic Variables in Healthy Women in Shuttle Walk Test
Healthy
Primary: Shuttle Walk Test Distance — 812 m
N/A N=80 Physiological Changes With High-Flow Nasal Cannula
Respiratory Distress Syndrome in Premature Infant
Primary: Percent of Unventilated Lung as Assessed by Electrical Impedance Tomography — 2.18; 2.32; 1.72; 2.17 Percent of unventilated lung regions
N/A N=25 Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia
Brain Hypoxia
Primary: Change in Glutamate Concentration During a Visual Stimulus Measured by fMRS at Normoxia — 4 percentage of concentration (micromol/g)
N/A N=112 Nitric Oxide and the Autonomic Nervous System
Hypertension · Pure Autonomic Failure
Primary: Change in Systolic Blood Pressure — 43; 21 mm Hg
N/A N=49 Physiology of Lung Collapse Under One-Lung Ventilation: Underlying Mechanisms
Lung Collapse · One-Lung Ventilation · Thoracic Surgery
Primary: Quantification of Gas Volume Coming From Ambient Air Towards the Alveoli Space of the Non-ventilated Lung During OLV With the Use of DLT and BB. — 504; 630 milliliters…
N/A N=24 The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly
Diabetes Mellitus, Type 2 · Insulin Resistance
Primary: Homeostasis Model Assessment Insulin Resistance (HOMA-IR) Index — 1.91; 0.84 units on a scale — p=0.001
N/A N=7 Physiology of GERD and Treatment Response
GERD
Primary: Change in GERD Symptoms — 0.6; -1.7 units on a scale — p=0.41
Phase 1 N=62 Muscle Perfusion and Protein Metabolism in Elderly
Aging
Primary: Mixed Muscle Fractional Synthesis Rate (FSR) — 0.061; 0.070; 0.066; 0.070 Fractional Synthesis Rate (pecent/hour)
N/A N=40 Physiological Flow of Liquids Used in Dysphagia Management (Neuro)
Amyotrophic Lateral Sclerosis · Parkinson Disease · Dysphagia
Primary: Number of Participants With Residue of Concern (Observational) — 6; 6; 3; 6 Participants
Phase 1 N=16 Evaluating the Benefits of Physiologic Insulin Delivery
Type 1 Diabetes
Primary: Glucagon Response to Induced Hypoglycemia — 4.8; 8.8; 5.8; 4.2 pg/mL
N/A N=120 Evaluation of Physiological Variables and Detection of Blood Loss in Healthy Adults With Different Subject Positioning by the CM-1500
Fluid Loss · Blood Loss
Primary: Impact of Subject Positioning on Percent Change of Heart Rate (HR) After Minor Blood Loss (e.g., 500mL) — 10.7; 14.7 percent change
N/A N=35 Gut Organoid and Microbiome Interactions in Hypertension
Gut Inflammation · Hypertension
Primary: Differential Gene Expression in Gut Epithelium — 29; 6 Differentially expressed gene
Phase 2 N=21 The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury
Spinal Cord Injury · Autonomic Dysreflexia · Baroreceptor Integrity
Primary: Systolic Blood Pressure — 93.21; 107.00; 95.8; 93.84 mmHg
N/A N=27 Novel Non-Invasive Monitoring Parameter in Healthy Volunteers
No Conditions · Focus is Respiratory Rate
Primary: The Covidien Nellcor Respiration Rate Software Shall Determine Respiration Rate Measured as Mean and Standard Deviation With Accuracy That is Non-inferior to Predicate…
N/A N=23 Dietary Nitrate and Physiological Aging
Aging
Primary: Change in Carotid Chemosensitivity Following 4 Weeks of Dietary Nitrate Supplementation and Placebo in Older Adults — -0.13; -0.05; -0.10; -0.11 L/min/%SpO2
N/A N=80 Physiological Flow of Liquids in Healthy Swallowing
Deglutition · Healthy Swallowing · Aging
Primary: Number of Participants With Unsafe Swallowing — 7; 1; 3; 0 Participants
N/A N=22 Endothelial Function and Cardiac Output in RV Pacing
Bradycardia
Primary: Endothelial Function Assessed by Flow Mediated Vasodilatation — 1.96; 1.73 EndoPAT index (EnFI)
N/A N=10 V2 Receptor Effects on Fluid Regulation and Performance
Electrolyte Imbalance · Hyponatremia · Hypernatremia
Primary: Sweat Sodium Concentration Obtained After the Steady-state Portion of the Trial — 80.1; 76.8; 84.7 mEq/L
N/A N=10 Clinical Evidence of pH Dependent ß2 Adrenergic Transport Mechanisms in the Airway
Healthy Volunteers
Primary: Changes in Airway Blood Flow After 180μg Albuterol by Inhalation (ΔQaw) vs Baseline — 16.8; 14.5; -0.2; 2.0 changes from baseline in μl.min-1.ml-1
Phase 4 N=74 Continuous Glucose Sensor Profiles in Non-Diabetic Subjects
Healthy Subjects Without Type 1 Diabetes
Primary: Overall Mean Sensor Glucose by Age Group — 98; 103; 97; 96 mg/dL — p=0.009
N/A N=32 Physiologic Adaptations to Interval and Continuous Running at Low Volume and Vigorous Intensity Over 14-Weeks.
Exhaustion - Physiological
Primary: Relative Maximal Oxygen Uptake — 47.8; 50.9; 49.7; 51.7 mL/(kg*min) — p=< 0.05
N/A N=16 Pressure Variability Study
Heart Failure
Primary: Mean Change in Pulmonary Artery Pressure (PAP) Due to Change in Posture — 27.7 mmHg — p=0.429
N/A N=90 Exploration of Blood Flow Regulation to Bone in Humans
Bone Blood Flow Regulation
Primary: Tibial Blood Perfusion — 0.54; -1.47; 0.43; 2.08 μM (concentration)
N/A N=72 Biological Response to Brief Psychological Challenge
Acute Inflammatory Response to Psychological Stress
Primary: Cell-free Mitochondrial DNA — 165.79; 405.56; 175.45; 164.45 Copies per uL — p=0.86
N/A N=14 Vascular Dysfunction During Physical Inactivity
Aging · Vascular Endothelium · Skeletal Muscle
Primary: Brachial Artery Vascular Function — 5.1; 3.1; 4.4 percent vasodilation
Phase 2 N=28 Circadian Rhythms of Aqueous Humor Dynamics in Humans
Glaucoma
Primary: Intraocular Pressure — 17.6; 16.4; 20.2; 17.0 mmHg — p=<.05
N/A N=12 Central Sodium Sensing: Implications for Blood Pressure Regulation
Salt Sensitivity of Blood Pressure
Primary: Functional Connectivity Between the Subfornical Organ and Organum Vasculosum of the Lamina Terminalis (Z-score) — 0.258490; 0.359145; 0.207372; 0.169055 z-score
N/A N=30 Respiration Rate V2.0 in Healthy Volunteers
Focus of the Study is Measuring Respiratory Rate
Primary: Mean Error (ME) +/- 1 Breath Per Minute, RR Sensor — -0.05 BrPM
Phase 3 N=59 Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables
Anesthesia
Primary: Change in Base Deficit — -1.5; -1.2; -0.5 mEq/L