N/A
Completed N=19
Eating Chocolate at the Right Time Benefits the Circadiam Sytem and Metabolic Efficiency.
Source: ClinicalTrials.gov NCT03949803 ↗Enrolled (actual)
19
Serious AEs
0.0%
Results posted
Apr 2025
Primary outcomePrimary: Resting Energy Expenditure (Indirect Calorimetry) — 1249.33; 1377.67; 1360.40; 1468.50 kcal/day
Summary
The purpose of this investigation is to test the hypothesis that in humans, eating a relatively big amount of chocolate at the wrong time (bedtime) may disrupt our circadian system (change the circadian phase), while taking this same amount of chocolate in the morning (wake up condition) may synchronize it. Other related factors may be also affected such as total body weight and body fat, dietary habits (total energy intake and macronutrient distribution), the timing of food intake and of sleep, daily rhythms of TAP, microflora composition and postprandial glycemia.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Resting Energy Expenditure (Indirect Calorimetry) |
1249.33; 1377.67; 1360.40; 1468.50; 1427.33; 1259.67 | — |
| PRIMARY Total Body Weight |
64.32; 61.97; 67.87; 74.08; 64.42; 61.95 | — |
| SECONDARY Fragmentation of Wrist Temperature (WT) Daily Rhythm |
0.23; 0.15; 0.25; 0.18; 0.13; 0.18 | — |
| SECONDARY Regularity of Wrist Temperature (WT) Daily Rhythm |
0.44; 0.45; 0.49; 0.32; 0.56; 0.35 | — |
| SECONDARY Amplitude of Wrist Temperature (WT) Daily Rhythm |
0.95; 1.42; 0.92; 0.89; 1.67; 0.94 | — |
| SECONDARY Changes in Microbiota Diversity (Inverse Simpson Index) |
39.72; 32.21; 25.37; 30.08; 52.15; 33.64 | — |
| SECONDARY Concentration of Total Short-chain Fatty Acids (SCFAs) |
419.93; 293.15; 588.49; 196.93; 659.92; 596.45 | — |
| SECONDARY Energy Intake |
1177.20; 1987.20; 1558.15; 2044.61; 1843.39; 2031.93 | — |
| SECONDARY Macronutrient Composition |
111.39; 198.72; 182.84; 202.74; 164.86; 171.72 | — |
Eligibility Criteria
Inclusion Criteria
- Healthy women
- Age: between 45 and 65 year of age
- Caucasian
- Menopause
Exclusion Criteria
- Pre-menopause women
- Endocrine (Diabetes mellitus or others), renal, hepatic, cancer or psychiatric disorders
- Receiving any pharmacologic treatment other than oral contraceptives
- Bulimia diagnosis, prone to binge eating
- Pregnancy
Data sourced from ClinicalTrials.gov (NCT03949803). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.