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Home › Conditions › Menopause

Menopause

Subtypes of Menopause

Post-menopause 2 Menopausal syndrome 1 Menopause-related problems 1 Postmenopausal Syndrome 1 Genitourinary Syndrome of Menopause 0 Perimenopause 0

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Menopause

55 trials tracked for Menopause: 27 in phase 3 or 4 and 8 with published results. The most-cited published study has 242 citations.

55Trials tracked
27Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 12 Phase 3 15 Phase 2 7 Phase 1 2 Other / NA 19
  1. Phase 3 Perimenopausal Estrogen Replacement Therapy Study Completed · 242 cited
  2. Phase 3 Using Soy Estrogens to Prevent Bone Loss and Other Menopausal Symptoms Completed · 179 cited
  3. Phase 4 LDX and Functional Magnetic Resonance Imaging (fMRI in Menopausal Women Completed · 86 cited
  4. Phase 4 Impact of Hot Flashes on Sleep and Mood Disturbance Completed · 77 cited
  5. Phase 3 The Vaginal Health Trial Completed · 54 cited
  6. Phase 3 A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms Completed · 25 cited
Show 44 more trials
  1. Phase 3 Estradiol Vaginal Softgel Capsules in Treating Symptoms of Vulvar and Vaginal Atrophy in Postmenopausal Women Completed · 22 cited
  2. Phase 4 Bone Health in Aging HIV Infected Women Completed · 8 cited
  3. Phase 4 Effect of Nuvigil on Fatigue Completed
  4. Phase 4 Vortioxetine for Menopausal Depression Completed
  5. Phase 4 Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder Completed
  6. Phase 4 Menopausal Sleep Fragmentation and Body Fat Gain Completed
  7. Phase 4 Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial Completed
  8. Phase 4 Estrogen Variability and Irritability During the Menopause Transition Completed
  9. Phase 4 Treating Insomnia and Improving Metabolic Health in Midlife Women With Insomnia Completed
  10. Phase 4 Duloxetine for Menopausal Depression Completed
  11. Phase 4 Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor Completed
  12. Phase 3 Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women Completed
  13. Phase 3 Effect of Oral Estradiol and Progesterone Therapy on Vaginal Cytokines in Postmenopausal Women Completed
  14. Phase 3 Study Evaluating The Effects Of Bazedoxifene/Conjugated Estrogens On Endometrial Safety And Postmenopausal Osteoporosis Completed
  15. Phase 3 Efficacy Study of Shortwave Diathermy for the Treatment of Patients With Knee Osteoarthritis Completed
  16. Phase 3 Dose-Finding Safety and Efficacy Trial of Org50081 (Esmirtazapine) in the Treatment of Vasomotor Symptoms (46101/P06459/MK-8265-012) Completed
  17. Phase 3 Dose-Finding Safety and Efficacy Trial of Org 50081 (Esmirtazapine) in the Treatment of Vasomotor Symptoms (177001/P06472/MK-8265-013) Completed
  18. Phase 3 Assessment of the Transfer of Using Levonorgestrel Intrauterine System (LNG IUS) as a Contraceptive to Using it as Part of Hormone Replacement Therapy (HRT). Completed
  19. Phase 3 A Clinical Trial to Evaluate the Safety and Efficacy of DR-2041(Synthetic Conjugated Estrogens, A) for Treatment of Vulvovaginal Atrophy Completed
  20. Phase 3 Therapy to Prevent Sexual Pain in Breast Cancer Survivors Completed
  21. Phase 3 Endometrial Safety of a Low Dose of Vagifem® in Postmenopausal Women With Atrophic Vaginitis Completed
  22. Phase 2 Efficacy and Safety of S-equol on Vasomotor Symptoms in Menopausal Patients Completed
  23. Phase 2 Research Investigation of Soy and Estrogen Completed
  24. Phase 2 A Study of BAY3427080 (NT-814) in the Treatment of Moderate to Severe Post-menopausal Vasomotor Symptoms Completed
  25. Phase 2 A Dose-ranging Study of the Efficacy of ESN364 in Postmenopausal Women Suffering Vasomotor Symptoms (Hot Flashes) Completed
  26. Phase 2 TXV13-01 Estradiol Vaginal Softgel Capsules in Treating Postmenopausal Women With Symptoms of Vulvar and Vaginal Atrophy Completed
  27. Phase 2 A TSEC for Symptom Management in Menopausal Women With Multiple Sclerosis Completed
  28. Phase 2 A Neurosteroid Intervention for Menopausal and Perimenopausal Depression Completed
  29. Phase 1 Raising Insulin Sensitivity in Post Menopause Completed
  30. Phase 1 Study Conducted to Further Understand the Elimination Pathways, Metabolite Profile and PK Profile of 14C-estetrol Completed
  31. N/A Comparison of Vaginal Laser Therapy to Vaginal Estrogen Therapy Completed
  32. N/A Controlled Trial of Tele-Support and Education for Womens Health Care in CBOCs Completed
  33. N/A The Effects of Swimming on Elderly Women With Stage-2 Hypertension Completed
  34. N/A HIRREM Hot Flashes Study Completed
  35. N/A A Study to Learn More About the Menopausal Hormone Therapies in Korea Completed
  36. N/A Electro-acupuncture for Menopausal Transition Symptoms Completed
  37. N/A Taekwondo Training and Postmenopausal Women With Stage-2 Hypertension Completed
  38. N/A Gabapentin for Insomnia Symptoms and Nighttime Vasomotor Symptoms (VMS) in Peri- and Postmenopausal Women Completed
  39. N/A MsFLASH-03: Comparative Efficacy of Low-Dose Estradiol and Venlafaxine XR for Treatment of Menopausal Symptoms Completed
  40. N/A Placebo Controlled Study of Atomoxetine in the Treatment of Mild to Moderate Cognitive Difficulties in Menopausal Women Completed
  41. N/A Estrogen and Serotonin on Changing Brain Chemistry Completed
  42. N/A MsFLASH-01: Escitalopram for Menopausal Symptoms in Midlife Women Completed
  43. N/A Behavioral Treatment of Menopausal Insomnia; Sleep and Daytime Outcomes Completed
  44. N/A Brown Adipose Tissue Activity in Pre- and Postmenopausal Women Completed

Showing the 50 most-cited and recently-updated of 55 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Cultural and Islamic values shape menopausal perceptions and health-seeking behavior in Saudi women
OB/GYN & Women's Health Sys. Review
Cultural and Islamic values shape menopausal perceptions and health-seeking behavior in Saudi women Cultural values shape how Saudi women experience menopause
This narrative review examines menopause experiences among Saudi women in primary healthcare settings. The authors synthesize qualitative fi…
A review shows cultural and Islamic values strongly influence how Saudi women perceive menopause and choose coping strategies.
Frontiers Jun 4, 2026
Massage improves menopause symptoms in systematic review and meta-analysis
Psychiatry Meta-analysis
Massage improves menopause symptoms in systematic review and meta-analysis Massage helps menopausal women feel better on many key measures
This systematic review and meta-analysis found that massage therapy significantly improves menopause-related symptoms, including total MRS s…
A review found massage significantly improved mood, fatigue, and hot flashes for menopausal women, though effects varied by specific symptom…
Jun 1, 2026
Systematic review and meta-analysis of creatine in postmenopausal women finds lean mass and strength benefits
Physical Medicine & Rehab Meta-analysis
Systematic review and meta-analysis of creatine in postmenopausal women finds lean mass and strength benefits Creatine and training may boost lean mass in postmenopausal women
This systematic review and meta-analysis of randomized trials in postmenopausal women found that creatine monohydrate supplementation increa…
A review of six studies found creatine with or without exercise increased lean muscle mass and strength in postmenopausal women without safe…
May 17, 2026
Narrative review discusses Erzhi Pill for osteoporosis and menopausal syndrome with noted limitations
Drug Pipeline Sys. Review
Narrative review discusses Erzhi Pill for osteoporosis and menopausal syndrome with noted limitations Ancient Pill Clears Fire, Nourishes Bones
This narrative review examines the Erzhi Pill for conditions including osteoporosis and menopausal syndrome.
An ancient Chinese pill treats both hot flashes and weak bones by cooling the upper body while strengthening the lower body, offering a holi…
Frontiers Apr 21, 2026
Systematic review finds 54.8% of Indian women with reproductive morbidities seek treatment
OB/GYN & Women's Health Meta-analysis
Systematic review finds 54.8% of Indian women with reproductive morbidities seek treatment Half of Indian women ignore reproductive pain
This systematic review and meta-analysis examined health-seeking behavior for reproductive morbidities among Indian women.
Ignoring common reproductive problems like pelvic pain or irregular periods leads to worse health outcomes for millions of women in India.
Frontiers Apr 11, 2026
Meta-analysis finds no significant gut microbiome differences in hypoestrogenic versus euestrogenic women
OB/GYN & Women's Health Meta-analysis
Meta-analysis finds no significant gut microbiome differences in hypoestrogenic versus euestrogenic women Large review finds no clear gut microbiome differences in women with low estrogen
A systematic review and meta-analysis of observational studies compared gut microbiome metrics in 1,267 hypoestrogenic women (post-menopausa…
A large review of women with low estrogen found no clear differences in gut bacteria diversity or major bacterial groups compared to those w…
Frontiers Apr 3, 2026
Resistance training increases muscle volume and strength in postmenopausal women with hot flushes
Radiology & Imaging RCT
Resistance training increases muscle volume and strength in postmenopausal women with hot flushes Can lifting weights build muscle in postmenopausal women with hot flashes?
A secondary analysis of an RCT in 44 postmenopausal women with hot flushes and low activity found that 15 weeks of supervised resistance tra…
Postmenopausal women with hot flashes who lifted weights for 15 weeks grew their muscle volume by about 4% and got significantly stronger.
Apr 2, 2026
Self-care education with laughter yoga shows benefits for menopausal symptoms and stress in small RCT
Primary Care & Family Medicine RCT
Self-care education with laughter yoga shows benefits for menopausal symptoms and stress in small RCT Can laughter yoga and self-care education ease menopause stress?
A randomized controlled trial of 64 postmenopausal women found that a menopause education program integrated with laughter yoga significantl…
A simple mix of laughter yoga and self-care education significantly reduced stress and physical symptoms for postmenopausal women in a new s…
Apr 2, 2026