N/A
N=44
Meditation Effects on Brain Function in Rheumatoid Arthritis
Rheumatoid Arthritis
Bottom Line
View on ClinicalTrials.gov: NCT03975595 ↗Enrolled (actual)
44
Serious AEs
0.0%
Results posted
Mar 2023
Primary outcome: Primary: Lateral Orbital Frontal Cortex Activation
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Meditation Intervention A (Behavioral); Meditation Intervention B (Behavioral)
- Age
- Adult, Older Adult · 30+ yrs
- Sex
- All
- Sponsor
- Johns Hopkins University
- Primary completion
- Oct 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Lateral Orbital Frontal Cortex Activation |
— | — |
| PRIMARY Nucleus Accumbens Activation |
16153.59; 15834.56 | — |
Summary
The purpose of this study is to determine the neural mechanisms supporting meditation-based pain relief in rheumatoid arthritis (RA) patients. The scientific premise is that RA patients' use of different meditation practices during noxious thermal stimulation will alter neural function in brain areas associated with pain, evaluation, and emotional appraisal. The investigators will randomize RA patients to a brief 4-session course of Intervention A (n=20) or Intervention B (n=20). At post-intervention, participants will undergo functional MRI (fMRI) using a perfusion-based arterial spin labeling (ASL) technique during noxious thermal stimulation to determine if the meditation practices differentially alter neural function during noxious thermal stimulation.
Eligibility Criteria
Inclusion Criteria
- Withheld to preserve recruitment integrity.
Exclusion Criteria
- Withheld to preserve recruitment integrity.
Data sourced from ClinicalTrials.gov (NCT03975595). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.