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N/A N=50 Diagnostic

Deep-Learning Image Reconstruction in CCTA

Coronary Artery Disease

Enrolled (actual)
50
Serious AEs
0.0%
Results posted
Nov 2021
Primary outcome: Primary: Subjective Image Quality — 5; 5 Score on a Likert scale (0-5) 5=best

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
TrueFidelity (Device)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
University of Zurich
Primary completion
Jun 2019

Outcome Measures

OutcomeResultp-value
PRIMARY
Subjective Image Quality
5; 5
SECONDARY
Signal Intensity
462; 443 0.198
SECONDARY
Image Noise
27; 28 0.9
SECONDARY
Signal-to-noise Ratio
17; 16 0.8
SECONDARY
Dose-length Products
31; 52 <0.001 sig
SECONDARY
Plaque Volumes
12.42; 13.84

Summary

Cardiac CT allows the assessment of the heart and of the coronary arteries by use of ionising radiation. Although radiation exposure was significantly reduced in recent years, further decrease in radiation exposure is limited by increased image noise and deterioration in image quality. Recent evidence suggests that further technological refinements with artificial intelligence allows improved post-processing of images with reduction of image noise. The present study aims at assessing the potential of a deep-learning image reconstruction algorithm in a clinical setting. Specifically, after a standard clinical scan, patients are scanned with lower radiation exposure and reconstructed with the DLIR algorithm. This interventional scan is then compared to the standard clinical scan.

Eligibility Criteria

Inclusion Criteria

  • Patients referred for cardiac CT angiography
  • Age ≥ 18 years
  • Written informed consent

Exclusion Criteria

  • Pregnancy or breast-feeding
  • Enrollment of the investigator, his/her family members, employees and other dependent persons
  • Renal insufficiency (GFR below 35 mL/min/1.73 m²)
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03980470). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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