N/A
Completed N=14
Muscle Capillarization and Sarcopenia
Source: ClinicalTrials.gov NCT03984994 ↗Enrolled (actual)
14
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcomePrimary: Skeletal Muscle Capillarization — 0.4; 0.2 capillaries per muscle fiber — p=0.27
Summary
Aging is associated with a loss of muscle mass, termed sarcopenia, that reduces mobility, decreases physical function and accelerates progression of other age-related disorders. This study is designed to determine whether increasing skeletal muscle capillarization through aerobic exercise will enhance muscular adaptations to strength training in older adults with sarcopenia.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Skeletal Muscle Capillarization |
0.4; 0.2 | 0.27 |
| PRIMARY Quadriceps Muscle Cross-sectional Area |
2.5; 0.7 | 0.22 |
| SECONDARY Skeletal Muscle Fiber Size |
607; 356 | 0.21 |
| SECONDARY Muscle Strength |
12.7; 2.0 | 0.28 |
Eligibility Criteria
Inclusion Criteria
- Body Mass Index = 18-32.5 kg/m2
- Non-smoker
- Presence of at least moderate sarcopenia (low muscle mass per unit body height)
Exclusion Criteria
- Diagnosis of diabetes, cancer, pulmonary or renal disease
- Physical impairment preventing exercise
- Recent history of exercise training
Data sourced from ClinicalTrials.gov (NCT03984994). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.