N/A
N=30
High Intensity Interval Training in Endometrial Cancer
Endometrial Cancer
Bottom Line
View on ClinicalTrials.gov: NCT04025229 ↗Enrolled (actual)
30
Serious AEs
—
Results posted
Aug 2025
Primary outcome: Primary: Change in Proliferative Markers in Endometrium Before and After HIIT Exercises — 21.7; 15.1; 21.7; 20.2 Percentage of cells expressing Ki67
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- HIIT exercise (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- Female
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
- Primary completion
- Sep 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Proliferative Markers in Endometrium Before and After HIIT Exercises |
21.7; 15.1; 21.7; 20.2 | — |
Summary
This interventional trial recruits women with endometrial cancer to participate in high intensity interval training (HIIT) prior to their standard of care surgery. The study will evaluate tissue and blood to determine if HIIT training has anti-cancer effects. P
Eligibility Criteria
Inclusion Criteria
- Patients with a diagnosis of endometrial cancer who are to undergo hysterectomy and staging
- Between 40-75 years old
- Body mass index of 30-50 kg/m2
- Endometrioid histology endometrial cancer
- Presumed clinically early stage disease (disease confined to uterus only)
- Have access to a Smart Phone
- Have access to email
- Agree to visit the exercise and sport science laboratory within 2 days of SOC visit for baseline testing if enrollment procedures cannot be done on the same day.
Agree to visit clinic 2 (+/-2wks) weeks after surgery for SOC follow-up and post surgery visit, or willing to return to exercise and sport science laboratory 2 (+/-2wks) weeks post-surgery
Exclusion Criteria
- Meets American College of Sports Medicine Guidelines for physical activity (150 minutes / week)
- Currently doing HIIT
- Hospitalization for a stroke, heart attack, or heart failure, or had surgery for blocked arteries in the past 3 months
- Active diagnosis of psychosis or current uncontrolled substance abuse disorder
- Insulin-dependent diabetes
- Currently in another EC intervention
- Severe dementia or other memory loss condition
- Severe mental health disorder
- Severely impaired hearing or speech
- Inability to speak English
- Musculoskeletal or neuromuscular condition that limits physical activity Any condition, in the opinion of the investigators, which would prohibit safe participation.
Data sourced from ClinicalTrials.gov (NCT04025229). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.