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Home › Conditions › Endometrial Cancer

Endometrial Cancer

18 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Endometrial Cancer

118 trials tracked for Endometrial Cancer: 9 in phase 3 or 4 and 5 with published results. The most-cited published study has 372 citations.

118Trials tracked
9Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 3 9 Phase 2 82 Phase 1 7 Other / NA 20
  1. Phase 3 Standard Versus Intensity-Modulated Pelvic Radiation Therapy in Treating Patients With Endometrial or Cervical Cancer Completed · 372 cited
  2. Phase 3 Bevacizumab and Intravenous or Intraperitoneal Chemotherapy in Treating Patients With Stage II-III Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer Completed · 235 cited
  3. Phase 3 Lenvatinib in Combination With Pembrolizumab Versus Treatment of Physician's Choice in Participants With Advanced Endometrial Cancer (MK-3475-775/E7080-G000-309 Per Merck Standard Convention [KEYNOTE-775]) Completed · 153 cited
  4. Phase 3 Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Versus Chemotherapy for Endometrial Carcinoma (ENGOT-en9 / MK-7902-001) Completed · 67 cited
  5. Phase 3 Zoptarelin Doxorubicin (AEZS 108) as Second Line Therapy for Endometrial Cancer Completed · 10 cited
  6. Phase 3 Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Versus Chemotherapy for Endometrial Carcinoma (ENGOT-en9 / MK-7902-001) - China Extension Study Completed
Show 44 more trials
  1. Phase 3 Carboplatin and Paclitaxel With or Without Bevacizumab in Treating Patients With Stage III or Stage IV Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer Completed
  2. Phase 3 Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Liposomal Doxorubicin for Cancer Completed
  3. Phase 3 Comparison of Two Combination Chemotherapy Regimens Plus Radiation Therapy in Treating Patients With Stage III or Stage IV Endometrial Cancer Completed
  4. Phase 2 A Study of Onapristone ER Alone Or In Combination With Anastrozole in Gynecologic Cancers That Respond to Progesterone Completed
  5. Phase 2 SYD985 in Patients With HER2-expressing Recurrent, Advanced or Metastatic Endometrial Carcinoma Completed
  6. Phase 2 Megestrol Acetate Plus Metformin to Megestrol Acetate in Patients With Endometrial Atypical Hyperplasia or Early Stage Endometrial Adenocarcinoma Completed
  7. Phase 2 Dalantercept in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed
  8. Phase 2 A Trial for Patients With Advanced/Recurrent Endometrial Cancer Completed
  9. Phase 2 A Study of Patients Receiving High-Dose Rate Brachytherapy Completed
  10. Phase 2 Tisotumab Vedotin Continued Treatment in Patients With Solid Tumors. Completed
  11. Phase 2 Bevacizumab in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed
  12. Phase 2 Evaluation of Carboplatin/Paclitaxel With and Without Trastuzumab (Herceptin) in Uterine Serous Cancer Completed
  13. Phase 2 Enzalutamide, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV or Recurrent Endometrioid Endometrial Cancer Completed
  14. Phase 2 ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma Completed
  15. Phase 2 Trebananib in Treating Patients With Persistent or Recurrent Endometrial Cancer Completed
  16. Phase 2 Bevacizumab and Rucaparib in Recurrent Carcinoma of the Cervix or Endometrium Completed
  17. Phase 2 Sunitinib Malate in Treating Patients With Recurrent or Metastatic Endometrial Cancer Completed
  18. Phase 2 Pembrolizumab in Ultramutated and Hypermutated Endometrial Cancer Completed
  19. Phase 2 A Phase II Study to Evaluate the Efficacy of TKI258 for the Treatment of Patients With FGFR2 Mutated or Wild-type Advanced and/or Metastatic Endometrial Cancer Completed
  20. Phase 2 A Study of Sapanisertib, Combination of Sapanisertib With MLN1117, Paclitaxel and Combination of Sapanisertib With Paclitaxel in Women With Endometrial Cancer Completed
  21. Phase 2 Survivorship Promotion In Reducing IGF-1 Trial Completed
  22. Phase 2 Study of Immune Response Modifier in the Treatment of Breast, Ovarian, Endometrial and Cervical Cancers Completed
  23. Phase 2 ZW25 in Women With Endometrial Cancers Completed
  24. Phase 2 Copanlisib in Treating Patients With Persistent or Recurrent Endometrial Cancer Completed
  25. Phase 2 Fondaparinux in Preventing Blood Clots in Patients Undergoing Surgery for Gynecologic Cancer Completed
  26. Phase 2 AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma Completed
  27. Phase 2 Safety Study Of Avastin And Pelvic Radiation In Women With Recurrent Gynecological Cancers Completed
  28. Phase 2 Elesclomol Sodium and Paclitaxel in Treating Patients With Recurrent or Persistent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer Completed
  29. Phase 2 Study of Lenvatinib in Subjects With Advanced Endometrial Cancer and Disease Progression Completed
  30. Phase 2 Lapatinib in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed
  31. Phase 2 Intensity-Modulated Radiation Therapy to the Pelvis With or Without Chemotherapy in Treating Patients With Endometrial Cancer or Cervical Cancer That Has Been Removed By Surgery Completed
  32. Phase 2 Study of LY3023414 for the Treatment of Recurrent or Persistent Endometrial Cancer Completed
  33. Phase 2 Study of Sacituzumab Govitecan-hziy (IMMU-132) in Adults With Epithelial Cancer Completed
  34. Phase 2 A Randomized Pilot Study to Evaluate the Effects of a Short Course of Metformin Versus No Therapy in the Period Prior to Hysterectomy for Grade 1-2 Adenocarcinoma of the Endometrium in Obese Non-Diabetic Women Completed
  35. Phase 2 Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors Completed
  36. Phase 2 A Study of Nivolumab in Selected Uterine Cancer Patients Completed
  37. Phase 2 Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors Completed
  38. Phase 2 Vaginal Cuff Brachytherapy Followed by Chemotherapy in Patients With Endometrioid Cancer Completed
  39. Phase 2 A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors Completed
  40. Phase 2 Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers Completed
  41. Phase 2 Bevacizumab and Temsirolimus in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed
  42. Phase 2 Gemcitabine in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed
  43. Phase 2 Intensity-Modulated Radiation Therapy, Cisplatin, and Bevacizumab Followed by Carboplatin and Paclitaxel in Treating Patients Who Have Undergone Surgery for Endometrial Cancer Completed
  44. Phase 2 A Study of Durvalumab With or Without Tremelimumab in Endometrial Cancer Completed

Showing the 50 most-cited and recently-updated of 118 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Endometrial Cancer: what the trials found

Pembrolizumab demonstrated significant improvements in progression-free survival (PFS) for both mismatch repair proficient (pMMR) and all-comer participants compared to standard treatments 4. In a smaller cohort, Pembrolizumab also showed a statistically significant improvement in overall response rate (ORR) 12.

Several agents were evaluated without demonstrating statistically significant differences in primary endpoints. Bevacizumab did not show significant differences in median progression-free survival 3 or in progression-free survival and overall survival across multiple trials 9. Lenvatinib showed no significant difference in progression-free survival for pMMR participants 5 or all randomized participants 5, nor was there a statistically significant difference in its ORR or overall survival in pMMR patients 7. Additionally, AEZS-108/zoptarelin doxorubicin did not show significant differences compared to doxorubicin regarding overall survival, objective response rate, or progression-free survival 6.

Radiation therapy was associated with a statistically significant decrease in the EPIC Bowel Domain Score at 5 weeks 2, though the percentage of patients with acute Grade 2+ gastrointestinal toxicity did not differ significantly 2. Radiation also showed significant differences in changes to the EPIC Urinary Domain score 2. Carboplatin was evaluated across multiple trials without reported outcome metrics for comparison [15, 16, 19].

Recent results — preliminary, needs further review

  • * The implementation of an AH-HA Tool in the EPIC EHR significantly increased the proportion of patients reporting discussion of at least one non-ideal or missing cardiovascular health (CVH) topic compared to standard practice 1. * Onapristone ER was evaluated in a Phase 2 trial 11.

For the clinician treating this condition

  • Pembrolizumab is associated with statistically significant improvements in progression-free survival for both pMMR and all-comer populations 4.
  • Bevacizumab, Lenvatinib, and AEZS-108/zoptarelin doxorubicin did not show statistically significant improvements over their respective comparators in primary efficacy endpoints (PFS, OS, or ORR) [3, 5, 6, 7, 9].
  • Radiation therapy is associated with a statistically significant reduction in the EPIC Bowel Domain Score at 5 weeks post-treatment 2.

AI synthesis of 10 cited trials, updated Jun 28, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
MMR status-guided immunotherapy provides favorable cost-effectiveness and quality-adjusted survival in dMMR/MSI-H endometrial cancer
Allergy & Immunology Sys. Review
MMR status-guided immunotherapy provides favorable cost-effectiveness and quality-adjusted survival in dMMR/MSI-H endometrial cancer MMR Testing Helps Identify High Value Treatment for Endometrial Cancer
This mini review examines the economic value of mismatch repair (MMR) status-guided immunotherapy for advanced and recurrent endometrial can…
Testing for mismatch repair status helps doctors identify which patients with advanced endometrial cancer may benefit most from specific imm…
Frontiers Sep 10, 2026
Impact of Lifestyle and Nursing Interventions on Quality of Life in Gynecologic Cancers
Oncology Meta-analysis
Impact of Lifestyle and Nursing Interventions on Quality of Life in Gynecologic Cancers Nursing and lifestyle support improve quality of life for ovarian cancer
A meta-analysis of 915 patients indicates that lifestyle and nursing interventions significantly improve quality of life specifically in ova…
Specialized nursing and lifestyle programs can significantly improve the quality of life for women living with ovarian cancer.
Sep 4, 2026
Obesity, high-grade tumors, and nonendometrioid histology raise SLN mapping failure risk in endometrial cancer
OB/GYN & Women's Health Meta-analysis
Obesity, high-grade tumors, and nonendometrioid histology raise SLN mapping failure risk in endometrial cancer Obesity and Tumor Grade Linked to Mapping Failures in Cancer Surgery
This meta-analysis of observational studies, including 6977 patients with apparent early-stage endometrial cancer undergoing minimally invas…
Certain factors like obesity and high tumor grade may increase the risk of mapping failures during surgery for early-stage endometrial cance…
Sep 2, 2026
Community governance models for nutrition-oriented care aim to reduce survival disparities across multiple cancers
Allergy & Immunology Sys. Review
Community governance models for nutrition-oriented care aim to reduce survival disparities across multiple cancers Community governance can improve nutrition care for cancer patients
This mini review explores the role of community governance in integrating nutritional support into oncology services for breast, cervical, o…
Newer policy models aim to bridge the gap in nutrition care, helping women with various cancers access better food security and support.
Frontiers Aug 18, 2026
Reduced-port robotic surgery offers comparable perioperative outcomes to multiport surgery in endometrial cancer
Oncology Meta-analysis
Reduced-port robotic surgery offers comparable perioperative outcomes to multiport surgery in endometrial cancer Reduced-Port Robotic Surgery Shows Similar Safety for Endometrial Cancer
This meta-analysis of 905 patients compares reduced-port and multiport robotic surgery for endometrial cancer. The analysis found no signifi…
Reduced-port robotic surgery shows similar safety and recovery times compared to multiport methods for patients with endometrial cancer.
Aug 13, 2026
Dostarlimab and Niraparib Combination Improves Progression Free Survival in Advanced Endometrial Cancer
Oncology RCT
Dostarlimab and Niraparib Combination Improves Progression Free Survival in Advanced Endometrial Cancer Adding Niraparib to Dostarlimab Delays Endometrial Cancer Worsening
A Phase 3 trial shows that adding niraparib to dostarlimab maintenance significantly extends progression-free survival for patients with adv…
A phase 3 trial found that adding niraparib to dostarlimab after chemo slowed cancer growth in advanced endometrial cancer, but did not exte…
Aug 10, 2026
Robotic and Laparoscopic Hysterectomy Show Equivalent Oncologic Outcomes
OB/GYN & Women's Health Meta-analysis
Robotic and Laparoscopic Hysterectomy Show Equivalent Oncologic Outcomes Robotic surgery shows similar survival outcomes for endometrial cancer patients
Meta-analysis of 91,151 patients finds robotic and laparoscopic hysterectomy yield comparable survival and recurrence, with robotic reducing…
A large analysis finds that robotic-assisted surgery provides the same survival rates as traditional laparoscopy for patients with endometri…
Aug 2, 2026
Sugar sweetened beverages and orange juice are associated with increased risk of several cancer types
Nutrition & Obesity Medicine Sys. Review
Sugar sweetened beverages and orange juice are associated with increased risk of several cancer types Sugar sweetened drinks may increase risk of several cancer types
This meta-analysis of 51 cohort studies evaluates the link between sugar sweetened beverages (SSBs), artificially sweetened beverages (ASBs)…
New research suggests a link between sugar-sweetened beverages and an increased risk of certain cancers, including pancreatic and colorectal…
medRxiv Jul 7, 2026
miRNA panels show high diagnostic accuracy for endometrial cancer in meta-analysis
Oncology Meta-analysis
miRNA panels show high diagnostic accuracy for endometrial cancer in meta-analysis miRNA Panels Show High Accuracy for Endometrial Cancer Diagnosis
This meta-analysis of 531 participants found that miRNA panels have high diagnostic accuracy for endometrial cancer, with pooled sensitivity…
A new analysis finds miRNA panels may accurately detect endometrial cancer, but more research is needed before routine use.
Jul 4, 2026
SUVmax demonstrates moderate accuracy in predicting lymphovascular space invasion in endometrial cancer patients
OB/GYN & Women's Health Meta-analysis
SUVmax demonstrates moderate accuracy in predicting lymphovascular space invasion in endometrial cancer patients PET scan measure predicts cancer spread risk with moderate accuracy
This meta-analysis evaluated the diagnostic accuracy of SUVmax from PET/CT or PET/MR for detecting lymphovascular space invasion (LVSI) in e…
A PET scan measure called SUVmax can predict whether endometrial cancer has spread to lymph vessels, with 83% specificity, but results may b…
Jul 1, 2026
NLRP3 inflammasome modulates immune evasion and chemotherapy sensitivity in gynecological cancers
Allergy & Immunology Sys. Review
NLRP3 inflammasome modulates immune evasion and chemotherapy sensitivity in gynecological cancers New research identifies a key driver in gynecological cancer cells
This mini-review examines the role of the NLRP3 inflammasome in ovarian, endometrial, and cervical cancers. It highlights how NLRP3 impacts …
A protein called NLRP3 helps certain cancers hide from the immune system, but it also plays a complex role in how tumors react to treatment.
Frontiers Jun 24, 2026
Combined pelvic and para-aortic lymphadenectomy improves overall survival compared to no lymphadenectomy in endometrial cancer
Oncology Meta-analysis
Combined pelvic and para-aortic lymphadenectomy improves overall survival compared to no lymphadenectomy in endometrial cancer Combined lymphadenectomy may improve survival for endometrial cancer patients
This meta-analysis of 25,432 patients found that combined pelvic and para-aortic lymphadenectomy (PPaLND) is associated with significant imp…
A large review of over 25,000 cases suggests that a more extensive surgical removal of lymph nodes can improve survival in some endometrial …
Frontiers Jun 11, 2026

Questions about Endometrial Cancer

Is there a link between the microbiome and Endometrial Cancer?

Yes, research links microbiome changes (dysbiosis) to endometrial cancer risk through inflammation, immune effects, and estrogen metabolism.

Full answer →
What are the current research trends for immune checkpoint inhibitors in Endometrial Cancer?

Current research focuses on PD-1/PD-L1 inhibitors, especially for MSI-H tumors, combination therapies, and understanding molecular subtypes to improve immunotherapy response in endometrial cancer.

Full answer →
Does combined pelvic and para-aortic lymphadenectomy improve survival for Endometrial Cancer?

Combined pelvic and para-aortic lymphadenectomy may improve survival in intermediate/high-risk endometrial cancer, but evidence is mixed and not definitive for all stages.

Full answer →

All Endometrial Cancer Articles