N/A N=5 Randomized Other

Neurological Impacts of Artificial Sweeteners in the Context of Diet Sodas

Obesity

Bottom Line

View on ClinicalTrials.gov: NCT04048681 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Feb 2020

Primary outcome: Primary: Changes in Brain Response to Food Cues in the Insula — 0.25; -0.9; -0.01 z-score

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: diet soda (Behavioral); Regular soda (Behavioral); Carbonated Water (Behavioral)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Beth Israel Deaconess Medical Center
Primary completion: Dec 2019

Outcome Measures

Outcome	Result	p-value
PRIMARY Changes in Brain Response to Food Cues in the Insula	0.25; -0.9; -0.01	—
SECONDARY Neurocognitive Testing (Stop Signal Reaction Time)	162.6; 172.9; 180.2	—

Summary

This study seeks to determine whether artificial sweeteners in the context of diet soda may alter the brain's response to food cues and thus impact appetite.

Eligibility Criteria

Inclusion Criteria

Men and women who are 18-65 years old, with a BMI >30kg/m2.

Exclusion Criteria

Unable or unwilling to participate in the study for any reason
Metal in the body or other safety concerns which makes patient unable to have an MRI
Pregnant women will be excluded to protect the fetus against potential effects of a non-medically required MRI on fetal development and difficulty of measuring accurate BMI.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04048681). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.