N/A
N=20
The Psychophysiological Effect of Simulated and Terrestrial Altitude
Hypoxia · Altitude Hypoxia · Altitude Sickness · Altitude · Mountain Sickness
Bottom Line
View on ClinicalTrials.gov: NCT04075565 ↗Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Feb 2026
Primary outcome: Primary: Oxygenation of the Brain — 54.6; 54.3; 59.4; 55.4 percentage of oxygen saturation
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Terrestrial altitude (Behavioral); Cloud 9 (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
- Primary completion
- Mar 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Oxygenation of the Brain |
54.6; 54.3; 59.4; 55.4; 55.6; 60.7 | — |
| PRIMARY Oxygenation of the Blood |
91.3; 89.5; 90.7; 95.8; 80.5; 78.7 | — |
| PRIMARY Mean Arterial Pressure |
93.6; 97.4; 98.1; 94.0; 114.7; 110.6 | — |
| PRIMARY Heart Rate |
77.6; 75.0; 86.0; 71.0; 141.6; 141.9 | — |
| PRIMARY Concentration of Blood Lactate |
2.0; 2.4; 2.3; 1.7; 5.0; 4.9 | — |
| PRIMARY Sleep Quality |
5.6; 7.0; 5.5; 5.8 | — |
| PRIMARY Altitude Sickness |
0.6; 1.4; 0.4; 0.6 | — |
| PRIMARY Concentration of Salivary Cortisol |
0.24; 0.31; 0.25; 0.23 | — |
Summary
The aim of this study is to compare the psychophysiological effects of terrestrial altitude with a normobaric, hypoxic situation.
Eligibility Criteria
Inclusion Criteria
- Healthy, adults aged 18 to 50 years
- No cardiovascular disease and / or surgery
- no surgery on the cardiovascular system.
- No current injuries and / or pain
- Regular and adequate sleep
- No terrestrial altitude of 1000 m exceeded last month (including flights)
- No form of hypoxia exposed last month
Exclusion Criteria
- Age over 50 years
- current injuries of any kind and / or pain
- Acute and / or chronic pain conditions Known general diseases (e.g., diabetes mellitus)
- fear of hypoxia
- fear of heights or sensitivity to terrestrial altitude
- Regular use of medicines (also bought by yourself), except for contraceptives
- Cardiovascular diseases or abnormalities
- Anomalies of the blood analysis or ECG
- Psychological disorders
- pregnancy / lactation
Data sourced from ClinicalTrials.gov (NCT04075565). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.