Phase 2
N=23
A Study of Neoadjuvant Nivolumab + Palbociclib + Anastrozole in Post-Menopausal Women and Men With Primary Breast Cancer
Breast Cancer · Cancer
Bottom Line
View on ClinicalTrials.gov: NCT04075604 ↗Enrolled (actual)
23
Serious AEs
34.8%
Results posted
Aug 2022
Primary outcome: Primary: The Number of Participants With Dose Limiting Toxicities (DLT) in the Safety Run-in Phase — 0; 2; 0 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Nivolumab (Biological); Anastrozole (Drug); Palbociclib (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Bristol-Myers Squibb
- Primary completion
- Jul 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY The Number of Participants With Dose Limiting Toxicities (DLT) in the Safety Run-in Phase |
0; 2; 0 | — |
| PRIMARY Residual Cancer Burden (RCB) 0-1 Rate in the Randomized Phase |
— | — |
| SECONDARY Objective Response Rate (ORR) |
0.0; 66.7; 75.0 | — |
| SECONDARY Breast Conserving Surgery (BCS) Rate |
50.0; 55.6; 50.0 | — |
| SECONDARY Pathological Complete Response (pCR) Rate |
0.0; 0.0; 8.3 | — |
| SECONDARY The Number of Participants Experiencing Adverse Events (AEs) |
2; 9; 12 | — |
| SECONDARY The Number of Participants Experiencing Serious Adverse Events (SAEs) |
0; 5; 2 | — |
| SECONDARY The Number of Participants Experiencing Adverse Events (AEs) Leading to Discontinuation |
0; 5; 4 | — |
| SECONDARY The Number of Participants Experiencing Immune-Related Adverse Events (AEs) |
1; 0; 0; 0; 0; 1 | — |
| SECONDARY The Number of Participants Deaths |
0; 0; 0 | — |
| SECONDARY The Number of Participants Experiencing Laboratory Abnormalities in Specific Thyroid Tests - SI Units |
1; 3; 2; 1; 2; 1 | — |
| SECONDARY The Number of Participants Experiencing Laboratory Abnormalities in Specific Liver Tests |
0; 4; 3; 0; 3; 3 | — |
Summary
A randomized multi-arm study evaluating the safety and efficacy of palbociclib and anastrozole with or without nivolumab in participants with ER+/HER2- breast cancer
Eligibility Criteria
For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com.
Inclusion Criteria
- Participants must have untreated, unilateral, histologically confirmed ER+, HER2- invasive breast cancer with primary tumor ≥2 cm in largest diameter (cT1-3) in one dimension by clinical or radiographic exam, for whom neoadjuvant endocrine monotherapy deemed to be a suitable therapy.
- Participants must be deemed eligible for surgery and must agree to undergo surgery after completion of neoadjuvant therapy and agree to provide tumor tissue at baseline, on-treatment, and at surgery.
- Women must have documented proof that they are not of childbearing potential.
- Participants must have a performance status (PS) ≤ 1 on the Eastern Cooperative Oncology Group (ECOG) scale
Exclusion Criteria
- Participants who may have had any treatment, including radiotherapy, chemotherapy, and/or targeted therapy administered for the currently diagnosed breast cancer prior to enrollment or for whom upfront chemotherapy is clinically judged appropriate as optimal neoadjuvant treatment.
- Participants who have a history of or active, known or suspected autoimmune disease, or other syndrome that requires systemic steroids above physiological replacement dose or autoimmune agents for the past 2 years.
- Prior treatment with either ET or CDK4/6 inhibitors for Breast Cancer (BC) within 5 years or an anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways, or history of allergy, or hypersensitivity to study drug components
- Prior malignancy active within the previous 3 years or participants with serious or uncontrolled medical disorders.
- Personal history of any of the following conditions: syncope of either unexplained or cardiovascular etiology, ventricular arrhythmia (including but not limited to ventricular tachycardia and ventricular fibrillation), long or short QT syndrome, Brugada syndrome, or known history of corrected QT prolongation, Torsade de Pointes, or sudden cardiac arrest.
Other protocol-defined inclusion/exclusion criteria apply.
Data sourced from ClinicalTrials.gov (NCT04075604). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.