N/A
N=108
A Personalized Approach to Effects of Affective Bias Modification on Symptom Change and Rumination
Major Depressive Disorder
Bottom Line
View on ClinicalTrials.gov: NCT04137367 ↗Enrolled (actual)
108
Serious AEs
0.0%
Results posted
Feb 2025
Primary outcome: Primary: Self-reported Depressive Symptoms: Becks Depression Inventory-II — 19.1; 16.5; 5.3 score on a scale — p=.05
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Affective bias modification (Behavioral); Sham Affective bias modification (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Oslo
- Primary completion
- Apr 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Self-reported Depressive Symptoms: Becks Depression Inventory-II |
19.1; 16.5; 5.3 | .05 |
| PRIMARY State Rumination: Brief State Rumination Inventory (BSRI) |
-.7; -5.8; -.8 | — |
| PRIMARY State Rumination: Brief State Rumination Inventory |
34.2; 32.3; 23.4 | — |
| SECONDARY Affective Bias: Dot-probe Task |
18.0; 9.4 | — |
| SECONDARY Symptom Network Change: Experience Sampling of Depressive Symptoms |
.0175; -.685 | — |
| SECONDARY Symptom Network: Experience Sampling of Depressive Symptoms |
.108; -.230 | — |
Summary
This study evaluates the effect of a computerized intervention for depressive symptoms called Affective Bias Modification (ABM). A third of the patients will receive active ABM, a third will receive sham ABM and a third will undergo assessment only. The study will investigate if rumination mediates the effect of the intervention and investigate if specific symptom profiles affect the effect of the intervention.
Eligibility Criteria
Inclusion Criteria
- Current or remitted Major Depressive Disorder, with or without anxiety, with or without alcohol use disorder
Exclusion Criteria
- Neurological disorder, mania, and/or psychosis.
Data sourced from ClinicalTrials.gov (NCT04137367). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.