N/A
N=29
Olfactory Contributions to Sleep-dependent Food Craving
Sleep Deprivation
Bottom Line
View on ClinicalTrials.gov: NCT04179838 ↗Enrolled (actual)
29
Serious AEs
0.0%
Results posted
Mar 2020
Primary outcome: Primary: Functional Magnetic Resonance Imaging (fMRI)-Based Decoding Accuracy of Food vs Non-food Odors in Piriform Cortex — 54.38; 49.65 Percentage correctly classified — p=0.001
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Sleep-Deprived (Behavioral); Non-Sleep Deprived (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Northwestern University
- Primary completion
- Aug 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Functional Magnetic Resonance Imaging (fMRI)-Based Decoding Accuracy of Food vs Non-food Odors in Piriform Cortex |
54.38; 49.65 | 0.001 sig |
| SECONDARY Energy-density of Consumed Food |
3.88; 3.68 | 0.021 sig |
| SECONDARY Ghrelin |
584.33; 573.47 | 0.63 |
| SECONDARY Leptin |
10.19; 9.68 | 0.08 |
| SECONDARY Total Calories of Consumed Food |
932.86; 946.49 | 0.28 |
| SECONDARY Insulin |
42.53; 48.56 | 0.50 |
| SECONDARY Cortisol |
6.08; 7.50 | 0.58 |
Summary
This within-subject experiment uses one night of acute sleep restriction (4h) vs normal sleep (8h) to study state-dependent changes in olfactory processing. Odor-evoked blood oxygen level dependent (BOLD) responses will be measured in olfactory brain regions using functional magnetic resonance imaging (fMRI). Food intake will be measured at a buffet.
Eligibility Criteria
Inclusion Criteria
- age between 18 and 40 years old
- regular sleep schedule (average sleep duration of ≥7 h/night, habitual mid-sleep time 3-5 am [deviation ≤2 h in daily mid-sleep time], time in bed ≤9 h)
- right-handed
- fluent English speakers
Exclusion Criteria
- history of significant cerebrovascular disease including (but not limited to) epilepsy, stroke, multiple sclerosis, meningitis
- body mass index (BMI) below 18.5 (underweight) or above 24.9 (overweight or obese)
- history of sleep disorder
- job with night shifts
- history of major head trauma with sustained loss of consciousness
- history of neurosurgery, ear-nose-throat (ENT) surgery, or cardiac surgery
- history of cardiac pacemaker or neurostimulator implantation
- history of significant medical illness including cardiovascular disease, diabetes, cancer, chronic obstructive pulmonary disease, severe asthma requiring hospitalization for treatment, renal insufficiency requiring dialysis, etc.
- history of major psychiatric disorder including major affective disorder, obsessive-compulsive disorder, schizophrenia
- claustrophobia
- history of significant food or non-food allergy, including latex, detergents, soaps
- presence of known smell, taste or ENT disorder
- history of sinusitis or allergic rhinitis
- history of alcoholism or consistent drug use
- current smoking
- current use of medications that affect alertness (e.g. barbiturates, benzodiazepines, cannabinoids, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, etc.)
- current pregnancy (or possible pregnancy)
- history of metal working, or injury with shrapnel or metal slivers
Data sourced from ClinicalTrials.gov (NCT04179838). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.