Phase 4
Completed N=73
Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion
Source: ClinicalTrials.gov NCT04187196 ↗Enrolled (actual)
73
Serious AEs
1.4%
Results posted
Nov 2023
Primary outcomePrimary: Time From Initiation of Sedation to Full Recovery — 7.6; 5.5 minutes
◆ Published Evidence
Emerging
4citations · ~1 / year
Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion.
Summary
A randomized, open-blinded, prospective study to evaluate the timeliness and safety of direct current cardioversion (DCCV) when using methohexital when compared to the more often used propofol.
Linked Publications
-
Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Time From Initiation of Sedation to Full Recovery |
7.6; 5.5 | — |
| SECONDARY Time From End of Injection to Loss of Conscious |
1.0; 1.0 | — |
| SECONDARY Time to First Electrical Direct-current Shock |
1.28; 1.2 | — |
| SECONDARY Time to Eyes Opening |
7.0; 4.2 | — |
| SECONDARY Systolic Blood Pressure |
132; 140; 138; 144; 124; 132 | — |
| SECONDARY Diastolic Blood Pressure |
78; 79.5; 82; 81.5; 70; 76 | — |
| SECONDARY Mean Arterial Blood Pressure |
104; 104.5; 102; 104.5; 91; 101.5 | — |
| SECONDARY Respiratory Rate |
16; 16.5; 18; 16.5; 17; 17 | — |
| SECONDARY Saturation of Peripheral Oxygen (SpO2) |
100; 100; 100; 100; 98; 99.5 | — |
| SECONDARY Heart Rate |
96; 93; 100; 92; 69; 73.5 | — |
| SECONDARY Recall of Pain at Injection Site - Visual Analog Scale |
8; 2 | — |
| SECONDARY Recall of Anything Unpleasant About the Procedure - Visual Analog Scale |
3; 1 | — |
Eligibility Criteria
Inclusion Criteria
- Patients who present to Wake Forest Baptist Medical Center for a direct current cardioversion for treatment of paroxysmal or persistent atrial fibrillation as well as atrial flutter.
Exclusion Criteria
- Patients with sedation for transesophageal echocardiogram within 30 minutes of DCCV
- Hemodynamically compromised patients (as defined by hypotension <90/50 mmHg, altered mental status, shock, ischemic chest discomfort, or heart failure)
Data sourced from ClinicalTrials.gov (NCT04187196) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.