Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › atrial flutter

Atrial flutter

Part of Cardiac arrhythmias

Subtypes of Atrial flutter

Typical atrial flutter 1

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for atrial flutter

26 trials tracked for atrial flutter: 9 in phase 3 or 4 and 1 with published results. The most-cited published study has 4 citations.

26Trials tracked
9Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 6 Phase 3 3 Phase 2 3 Other / NA 14
  1. Phase 4 Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion Completed · 4 cited
  2. Phase 4 Use of Dabigatran Etexilate to Prevent Stroke and Thromboembolism Completed
  3. Phase 4 Effect of Oral and Intravenous Diltiazem Protocol for Emergency Department Atrial Fibrillation Completed
  4. Phase 4 Isthmus Ablation With Gold Electrode for Treatment of Atrial Flutter (AURUM 8) Completed
  5. Phase 4 Catheter Evaluation for Endocardial Ablation in Patients With Typical Atrial Flutter Completed
  6. Phase 4 Concentrations of Amiodarone in Fat Tissue During Chronic Treatment Completed
Show 20 more trials
  1. Phase 3 Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery Completed
  2. Phase 3 A Trial With Dronedarone to Prevent Hospitalization or Death in Patients With Atrial Fibrillation Completed
  3. Phase 3 Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation Completed
  4. Phase 2 Cardiac Electrophysiological Study Completed
  5. Phase 2 Safety and Efficacy of Vanoxerine for Conversion of Atrial Fibrillation or Flutter to Normal Sinus Rhythm Completed
  6. Phase 2 Evaluate the Pharmacokinetics and Safety of MK-4448 in Participants With Nonvalvular Atrial Fibrillation or Atrial Flutter Completed
  7. N/A Clinical Evaluation of the Blazer® Open-Irrigated Catheter for Treatment of Type 1 Atrial Flutter Completed
  8. N/A iPhone Helping Evaluate Atrial Fibrillation Rhythm Through Technology Completed
  9. N/A An Initial Assessment of the Sphere-9™ Catheter and Affera Mapping and Ablation System Completed
  10. N/A FREEZE-AFIB Post-Market Study Completed
  11. N/A Evaluation of the Use of Apple Watch Features for Identification of Cardiac Arrhythmias Completed
  12. N/A Apple Heart Study: Assessment of Wristwatch-Based Photoplethysmography to Identify Cardiac Arrhythmias Completed
  13. N/A Impact of an Atrial Fibrillation Decision Support Tool (AFDST) on Thromboprophylaxis for Atrial Fibrillation Completed
  14. N/A Assessment of the Sphere-9™ Catheter and Affera Mapping and Ablation System for Treatment of Atrial and Ventricular Arrhythmias Completed
  15. N/A Clinical Study to Evaluate the Catheter Robotics Amigo for Performing Right-Sided Electrophysiology Mapping Studies Completed
  16. N/A Evaluation of the Amigo Robotic System for Ablation of the Cavo-Tricuspid Isthmus Completed
  17. N/A ArcticLine Feasibility Study Completed
  18. N/A Suture Closure AFtEr VEIN Access for Cardiac Procedures (SAFE-VEIN) Trial Completed
  19. N/A Wire Instrumentation Using Radiofrequency Energy to Impact Transseptal Efficiency Completed
  20. N/A Comparison of Intracardiac Echocardiography and Transesophageal Echocardiography Completed

Showing the 26 most-cited and recently-updated of 26 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Atrial flutter: what the trials found

Pharmacological management of atrial flutter includes various agents. Dronedarone was associated with a lower rate of first hospitalization for cardiovascular reasons or death from any cause compared to the control group (p<0.0001) 9. While dronedarone showed a significant reduction in hospitalizations, the difference in total deaths from any cause did not reach statistical significance (p=0.18) 9. Warfarin was evaluated for stroke and bleeding; it demonstrated significantly lower rates of adjudicated stroke or systemic embolism (p=0.0114) and significantly lower rates of major bleed events (p<0.0001) compared to the comparison group, while all-cause death rates were also significantly lower (p=0.0465) 8.

Interventional procedures for atrial flutter show high efficacy in achieving conduction block and success rates. RF energy delivery for typical atrial flutter resulted in a 93.3% rate of complete bidirectional conduction block (p=0.05) with a low incidence of cardiovascular-specific adverse events within seven days (1.5%, p=0.05) 4. The use of a gold tip catheter showed significant success with the first catheter (p=0.042), though duration of energy application did not differ significantly between groups (p=0.25) 5. Long-term treatment success was observed in patients treated with gold tip catheters, showing no statistically significant difference between groups (p=0.53) 5.

Other established interventions and technologies include the use of propofol 1, beta blockers 7, dabigatran etexilate mesylate 3, fat tissue needle aspiration 6, and specialized mapping systems such as the Sphere-9 Catheter and Affera Mapping and Ablation System, which reported a 19% rate of subjects free from documented recurrence 14.

Recent results — preliminary, needs further review

  • Amiodarone weight-based dosing showed specific steady-state concentrations (p-values not provided) 10.
  • AliveCor technology was associated with lower rates of atrial arrhythmia recurrence and shorter time to treatment for recurrence compared to the control group (p=0.05) 16.
  • ArcticLine Cardiac Cryoablation Catheter showed zero primary safety events within 7 days post-procedure 20.

For the clinician treating this condition

  • Dronedarone significantly reduces the risk of hospitalization for cardiovascular reasons or death compared to standard care 9.
  • Warfarin is associated with lower rates of stroke, systemic embolism, and major bleeding in patients undergoing treatment 8.
  • RF energy delivery for typical atrial flutter achieves a high rate of complete bidirectional conduction block (93.3%) with low early adverse events 4.

AI synthesis of 12 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Fragmented QRS is associated with a 2.11 risk ratio for post-ablation atrial tachyarrhythmia
Cardiology Meta-analysis
Fragmented QRS is associated with a 2.11 risk ratio for post-ablation atrial tachyarrhythmia Fragmented QRS Signals Linked to Higher Risk After Heart Surgery
This meta-analysis of six cohort studies evaluates the association between fragmented QRS (fQRS) and post-ablation outcomes in patients with…
A specific heart signal called fragmented QRS may help doctors identify patients at higher risk for recurring heart rhythm issues after surg…
Jul 1, 2026
SGLT2 inhibitors provide robust prognostic benefits in heart failure with inconsistent results in post-myocardial infarction settings
Cardiology Sys. Review
SGLT2 inhibitors provide robust prognostic benefits in heart failure with inconsistent results in post-myocardial infarction settings SGLT2 inhibitors show promise for heart failure and diabetes
This narrative review examines the cardiovascular and metabolic effects of SGLT2 inhibitors, specifically empagliflozin and dapagliflozin. T…
New evidence shows how SGLT2 inhibitors may protect the heart and manage risks for patients with type 2 diabetes and heart failure.
Frontiers Jun 9, 2026
Bipolar linear PFA shows similar safety to RFA for CTI ablation in persistent atrial fibrillation
Cardiology RCT
Bipolar linear PFA shows similar safety to RFA for CTI ablation in persistent atrial fibrillation PFA Ablation Matches Old Method With Less Time
This substudy RCT compared bipolar linear pulsed field ablation (PFA) with irrigated radiofrequency ablation (RFA) in 141 patients with pers…
Doctors can treat a specific heart rhythm problem faster with new technology without making it less safe.
Apr 16, 2026

Research across Cardiac arrhythmias

Related studies from across the Cardiac arrhythmias family.

Apixaban reduces stroke and systemic embolism in patients with subclinical atrial fibrillation and an implantable cardiac monitor
Cardiology RCT
Apixaban reduces stroke and systemic embolism in patients with subclinical atrial fibrillation and an implantable cardiac monitor Apixaban reduces stroke risk in patients with certain heart conditions
This randomized controlled trial evaluated 4012 patients with subclinical atrial fibrillation, including a cohort of 209 with an implantable…
A new analysis shows that apixaban may significantly lower stroke risks for patients with subclinical atrial fibrillation and specific cardi…
Jul 3, 2026
ICE vs TEE for atrial fibrillation ablation: no significant safety differences, shorter fluoroscopy
Cardiology Meta-analysis
ICE vs TEE for atrial fibrillation ablation: no significant safety differences, shorter fluoroscopy ICE and TEE show similar safety for heart procedures
This meta-analysis of 4760 adults undergoing atrial fibrillation catheter ablation found no significant differences between intracardiac ech…
Doctors are comparing two imaging tools to see which is safer for patients undergoing surgery to treat an irregular heartbeat.
Jul 3, 2026
Magnesium sulfate did not significantly reduce postoperative atrial fibrillation incidence in cardiac surgery patients
Cardiology RCT
Magnesium sulfate did not significantly reduce postoperative atrial fibrillation incidence in cardiac surgery patients Trial shows magnesium sulfate does not prevent heart rhythm issues
This randomized clinical trial of 265 adult patients undergoing coronary artery bypass grafting or valvular surgery found that magnesium sul…
A clinical trial found that giving patients magnesium during heart surgery did not reduce the risk of developing a common irregular heartbea…
Jul 3, 2026
ICM-guided congestion management shows no difference in arrhythmia occurrence rates for heart failure patients
Cardiology RCT
ICM-guided congestion management shows no difference in arrhythmia occurrence rates for heart failure patients Heart monitoring helps identify risks in heart failure patients
This randomized controlled trial of 711 ambulatory patients with symptomatic heart failure found no significant difference in arrhythmia occ…
New data shows that specific heart rhythm issues detected by implants can signal a higher risk of hospital stays and medical interventions.
Jul 3, 2026
Factor XI inhibitors reduce major bleeding but increase ischemic stroke risk in atrial fibrillation
Cardiology Meta-analysis
Factor XI inhibitors reduce major bleeding but increase ischemic stroke risk in atrial fibrillation Factor XI inhibitors show lower bleeding risk in atrial fibrillation patients
This meta-analysis of 16852 adults with atrial fibrillation found that Factor XI/XIa inhibitors significantly reduced ISTH major bleeding (O…
A new class of blood thinners may reduce major bleeding risks for people with atrial fibrillation, but they also show higher stroke rates.
Jul 1, 2026
Demographic and clinical factors associated with poststroke cognitive impairment in stroke patients
Cardiology Meta-analysis
Demographic and clinical factors associated with poststroke cognitive impairment in stroke patients Key risk factors identified for cognitive issues after stroke
This meta-analysis examined various risk factors, including age, gender, education level, and comorbidities like hypertension and diabetes, …
New data identifies how age, gender, and underlying conditions like diabetes and high blood pressure impact brain health after a stroke.
Jul 1, 2026
Catheter ablation reduces serious adverse events and unplanned hospitalizations by 20% and 47% in atrial fibrillation
Cardiology Meta-analysis
Catheter ablation reduces serious adverse events and unplanned hospitalizations by 20% and 47% in atrial fibrillation Catheter Ablation Shows Lower Risk for Atrial Fibrillation Patients
This meta-analysis of randomized trials evaluates catheter ablation versus antiarrhythmic drugs for atrial fibrillation management. The anal…
A meta-analysis of randomized trials suggests catheter ablation may lower risks of serious events and unplanned hospital stays for people wi…
Jul 1, 2026
Complete LVA ablation shows no arrhythmia-free survival benefit in persistent AF
Cardiology RCT
Complete LVA ablation shows no arrhythmia-free survival benefit in persistent AF Complete LVA Ablation Shows No Extra Benefit for AF
This post hoc subanalysis of an RCT compared complete low-voltage area (LVA) ablation versus no LVA ablation in 341 patients with persistent…
Adding complete low-voltage area ablation to standard AF treatment didn't improve outcomes in a new analysis.
Jun 26, 2026
Additional ablation after PVI improves AF freedom in non-diabetics but not in diabetics
Cardiology RCT
Additional ablation after PVI improves AF freedom in non-diabetics but not in diabetics Extra ablation may not help diabetes patients with atrial fibrillation
A subanalysis of an RCT in 493 patients undergoing catheter ablation for persistent AF found that adding linear and/or CFAE ablation to PVI …
For people with diabetes and atrial fibrillation, adding extra ablation beyond standard PVI may not lower recurrence risk.
Jun 26, 2026
Coexisting COPD and Atrial Fibrillation are associated with increased risk of mortality and bidirectional disease association
Cardiology Meta-analysis
Coexisting COPD and Atrial Fibrillation are associated with increased risk of mortality and bidirectional disease association Patients with both lung and heart conditions face higher risks
This meta-analysis of 48 publications identifies a significant bidirectional risk between Chronic Obstructive Pulmonary Disease (COPD) and A…
People living with both chronic lung disease and irregular heartbeats face significantly higher risks for mortality.
Frontiers Jun 19, 2026
Evaluating the Efficacy of Oral Digoxin in Patients with Rheumatic Heart Disease
Cardiology RCT
Evaluating the Efficacy of Oral Digoxin in Patients with Rheumatic Heart Disease Trial shows digoxin reduces heart failure risk in rheumatic heart disease
A large multicenter trial shows oral digoxin significantly reduces the risk of heart failure and death in patients with rheumatic heart dise…
A large clinical trial suggests that the medication digoxin may lower the risk of worsening heart failure for patients with rheumatic heart …
JAMA Jun 16, 2026
Incidental arrhythmia findings on ambulatory ECG vary widely in adults without prior atrial fibrillation
Cardiology Meta-analysis
Incidental arrhythmia findings on ambulatory ECG vary widely in adults without prior atrial fibrillation Hidden heart rhythm problems found in up to 96% of adults
This systematic review and meta-analysis of 136,344 community-based adults without prior atrial fibrillation found that the prevalence of in…
A review of 136,344 adults found hidden heart rhythm issues in up to 96% of people without known atrial fibrillation.
Jun 5, 2026