N/A
Completed N=28
Relative Sarcopenia and Cardiometabolic Risk in Young Adults With Obesity
Overweight and Obesity · Insulin Resistance
Source: ClinicalTrials.gov NCT04195061 ↗
Enrolled (actual)
28
Serious AEs
0.0%
Results posted
Jan 2024
Primary outcomePrimary: Percent Change in Serum Myostatin Levels From Pre- to 3 Hours Post-exercise — -6.9; 8.5 % change in serum myostatin — p=0.303
Summary
The goal of this research study is to learn more about the hormones that muscles make during exercise, and if those hormones are associated with type 2 diabetes risk in adults who are overweight or obese. Participants will undergo exercise testing on an upright bicycle, with blood samples taken for muscle hormones before and after exercise. The hypothesis is that adults with overweight/obesity and insulin resistance will have an impaired muscle hormone profile in response to exercise compared to adults with overweight/obesity who are not insulin resistant.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percent Change in Serum Myostatin Levels From Pre- to 3 Hours Post-exercise |
-6.9; 8.5 | 0.303 |
| SECONDARY Percent Change in Serum Myostatin Levels From Pre- to 2 Hours Post-exercise |
-9.7; 21.7 | 0.035 sig |
| SECONDARY Percent Change in Serum Myostatin Levels From Immediately Post to 2 Hours Post-exercise |
-20.3; 13.5 | 0.007 sig |
Eligibility Criteria
Inclusion Criteria
- Previously enrolled in protocol 2004P000013 or protocol 2012P002276, which had overweight or obesity as inclusion criteria
- Ability to walk up 3 flights of stairs and 3 city blocks (to ensure ability to complete exercise testing)
Exclusion Criteria
- Unstable heart or lung disease
- Exercise >150 minutes/week
- Participation in college sports
Data sourced from ClinicalTrials.gov (NCT04195061). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.