N/A N=28

Relative Sarcopenia and Cardiometabolic Risk in Young Adults With Obesity

Overweight and Obesity · Insulin Resistance

Bottom Line

View on ClinicalTrials.gov: NCT04195061 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jan 2024

Primary outcome: Primary: Percent Change in Serum Myostatin Levels From Pre- to 3 Hours Post-exercise — -6.9; 8.5 % change in serum myostatin — p=0.303

Study Design & Population

Study type: Observational
Phase: N/A
Interventions: Cardiopulmonary exercise test (CPET) (Procedure)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Massachusetts General Hospital
Primary completion: Nov 2021

Outcome Measures

Outcome	Result	p-value
PRIMARY Percent Change in Serum Myostatin Levels From Pre- to 3 Hours Post-exercise	-6.9; 8.5	0.303
SECONDARY Percent Change in Serum Myostatin Levels From Pre- to 2 Hours Post-exercise	-9.7; 21.7	0.035 sig
SECONDARY Percent Change in Serum Myostatin Levels From Immediately Post to 2 Hours Post-exercise	-20.3; 13.5	0.007 sig

Summary

The goal of this research study is to learn more about the hormones that muscles make during exercise, and if those hormones are associated with type 2 diabetes risk in adults who are overweight or obese. Participants will undergo exercise testing on an upright bicycle, with blood samples taken for muscle hormones before and after exercise. The hypothesis is that adults with overweight/obesity and insulin resistance will have an impaired muscle hormone profile in response to exercise compared to adults with overweight/obesity who are not insulin resistant.

Eligibility Criteria

Inclusion Criteria

Previously enrolled in protocol 2004P000013 or protocol 2012P002276, which had overweight or obesity as inclusion criteria
Ability to walk up 3 flights of stairs and 3 city blocks (to ensure ability to complete exercise testing)

Exclusion Criteria

Unstable heart or lung disease
Exercise >150 minutes/week
Participation in college sports

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04195061). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.