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Phase 3 N=48 Randomized Treatment

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery

Meniscus Tear, Tibial · Pain, Postoperative · Postoperative Complications · Ketorolac Adverse Reaction · Opioid Use

Enrolled (actual)
48
Serious AEs
0.0%
Results posted
Dec 2021
Primary outcome: Primary: Pain Levels Recorded With a Visual Analogue Scale — 25.6; 28.8 score on a scale

Study Design & Population

Study type
Interventional
Phase
Phase 3
Interventions
Ketorolac (Drug); Oxycodone-Acetaminophen (Drug)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
University Hospitals Cleveland Medical Center
Primary completion
Sep 2021

Outcome Measures

OutcomeResultp-value
PRIMARY
Pain Levels Recorded With a Visual Analogue Scale
25.6; 28.8
PRIMARY
Narcotic Medication Consumed
5.7; 3.5

Summary

The utilization of arthroscopic surgery to treat meniscus injuries has continued to increase in recent years, partly due to a younger, more active population, and improved technology and technique. However, pain management in the post-operative period is critical to the ability to perform this procedure as an outpatient surgery. Traditionally, oral narcotic agents have been the preferred analgesic postoperatively in orthopaedic surgery. However, these agents are associated with several side effects, including nausea/vomiting, constipation, and somnolence. In addition, opioid agents have a significant potential for abuse in comparison to non-narcotic analgesics. In light of the rising opioid epidemic and nationwide initiatives to limit narcotic usage, surgeons must explore alternate pain modalities in the acute postoperative period. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties.1 Multiple prior studies have examined the beneficial effect of oral and intravenous (IV) ketorolac as an analgesic in the postoperative period,1-3 including arthroscopic meniscus surgery. However, the beneficial effects of this agent following arthroscopic meniscus surgery have not been extensively described.

Eligibility Criteria

Inclusion Criteria

  • Patients between 18 and 89 years of age
  • Patients undergoing primary arthroscopic meniscus surgery

Exclusion Criteria

  • Patients age less than 18 or greater than 89 years
  • Illiterate or non-English speaking patients
  • Patients with contraindications to ketorolac
  • History of drug or alcohol abuse
  • Chronic use of analgesic or psychotropic drugs
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04246541). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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