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N/A N=77 Randomized Single-blind Treatment

The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia

Sarcopenia · High Blood Pressure · Hypertension

Enrolled (actual)
77
Serious AEs
0.0%
Results posted
Jun 2026
Primary outcome: Primary: Change in Blood Pressure — 125.5; 131.4; 125.0; 127.5 mmHg

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
progressive resistance training (Behavioral)
Age
Adult, Older Adult · 60+ yrs
Sex
All
Sponsor
University of Illinois at Chicago
Primary completion
Jun 2024

Outcome Measures

OutcomeResultp-value
PRIMARY
Change in Blood Pressure
125.5; 131.4; 125.0; 127.5; 81.2; 81.6

Summary

Current prevention and treatment of high blood pressure (BP) in sarcopenia, by non-pharmacological approaches remain limited and are far from optimal. This randomized control intervention pilot study will provide new evidence of the unexplored relationship between muscle strength and high BP in sarcopenia, and experimentally test the effects of an evidence-based progressive resistance training intervention on BP, while also examining reversibility to identify muscle strength as a non-pharmacological target for BP control in older sarcopenic adults.

Eligibility Criteria

Inclusion Criteria

  • Adults (men and women) aged 60 years and older (any racial/ethnic background)
  • Demonstrates adequate cognitive function by the MoCA (education adjusted score of >22 at screening)
  • Sedentary or low active adults (not active in strength training)
  • Resides in the Chicagoland Area
  • Able to walk/perform exercise without complete dependence on assisted device
  • Able and willing to enroll and provide written informed consent, i.e., to meet the time and data collection requirements of the study, be randomized to 1 of 2 treatment arms, follow through assignment during 3 months active period, participate in 1 follow-up visit at 12 months

Exclusion Criteria

  • Subjects with self-report of inability to walk at least ¼ mile or walk 400 meters in <15 minutes without sitting
  • Subjects who self-reported having a history of a cardiovascular disease event or physician diagnosed cardiovascular disease (heart attack, heart failure, congenital heart disease, peripheral vascular disease, coronary revascularization, or angina that required overnight hospitalization), cerebrovascular disease (stroke, transient ischemic attack)
  • Diagnosis of cancer (other than non-melanoma skin cancer) that is/was active or treated with radiation or chemotherapy within the past 5 years;
  • Subjects with orthopedic pathology or deformity that prevents exercising safely
  • Diagnosis or history of cognitive impairment (Dementia, Alzheimer's Disease) or bipolar or psychotic disorder or hospitalization for psychological or emotional problems within the last 2 years
  • Diagnosis of autoimmune diseases, such as (but not limited to) lupus, multiple sclerosis, advanced/severe rheumatoid arthritis that would preclude exercising safely
  • Diagnosis of advanced or severe osteoporosis or orthopedic deformities that may prevent strength training exercise safely
  • Participants from the same household as those already enrolled in the study
  • Current abuser of alcohol or usage of illicit drugs or history of alcohol or drug abuse
  • Planning to move out of the area or take an extended vacation during the study period
  • Current or planned participation in in another structured program that overtly focuses on exercise
  • Currently enrolled or planning to enroll into another research study that would limit full participation in the study
  • Investigator discretion for clinical safety or protocol adherence reasons
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04255745). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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