Early Phase 1
Completed N=24
Age-Related Effects of THC
Tolerance · Adolescent Behavior · THC
Source: ClinicalTrials.gov NCT04294966 ↗
Enrolled (actual)
24
Serious AEs
0.0%
Results posted
Nov 2023
Primary outcomePrimary: Change From Baseline in Profile of Mood States (POMS) — 5.75; 12.46; 18.55; 4.08 units on a scale
Summary
Increased accessibility to cannabis and its primary psychoactive constituent THC has raised public health concerns. One major concern surrounds the potential risks associated with acute THC intoxication and who might be most at risk. A second major concern is the need to develop sensitive measures that can detect THC intoxication after recent use and enable robust comparisons of intoxication to determine sources of risk. One potential source of risk is age, specifically during the period of adolescence.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline in Profile of Mood States (POMS) |
5.75; 12.46; 18.55; 4.08; 5.05; 6.25 | — |
Eligibility Criteria
Inclusion Criteria
- 18-20 years old OR 30-40 years old
- Body Mass Index 19-26
- High school education, fluent in English
- Occasional cannabis users ( 0 times in past 30 days AND used cannabis no more than 20 times in lifetime)
Exclusion Criteria
- History of daily cannabis use
- Past or present severe substance use disorder
- Current or past diagnosis with drug treatment for psychosis/bipolar/schizophrenia
- Cardiovascular illness, high blood pressure, abnormal electrocardiogram
- Current medications
- Pregnant or planning to become pregnant
Data sourced from ClinicalTrials.gov (NCT04294966). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.