Phase 4
N=168
A Study to Evaluate Androderm®'s Effect on Blood Pressure in Adult Hypogonodal Male Participants
Hypogonadism
Bottom Line
View on ClinicalTrials.gov: NCT04320745 ↗Enrolled (actual)
168
Serious AEs
1.2%
Results posted
Jul 2022
Primary outcome: Primary: Change From Baseline in 24-hour Average Systolic Blood Pressure (SBP) Obtained at Week 16 — 123.2; 3.5 millimeters of mercury (mmHg)
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Androderm® (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- Male
- Sponsor
- Allergan
- Primary completion
- Jun 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline in 24-hour Average Systolic Blood Pressure (SBP) Obtained at Week 16 |
123.2; 3.5 | — |
| SECONDARY Change From Baseline in 24-hour Average Diastolic Blood Pressure (DBP) Obtained at Week 16 |
74.4; 1.2 | — |
| SECONDARY Change From Baseline in 24-hour Average Mean Arterial Pressure (MAP) Obtained at Week 16 |
90.4; 1.7 | — |
| SECONDARY Change From Baseline in 24-hour Average Pulse Pressure Obtained at Week 16 |
48.8; 2.3 | — |
| SECONDARY Change From Baseline in 24-hour Average Heart Rate Obtained at Week 16 |
72.4; 2.2 | — |
Summary
This study will evaluate the effect of a once daily Androderm® dose on Blood Pressure (BP) in adult hypogonadal men as measured by 24-hour ABPM.
Eligibility Criteria
Inclusion Criteria
- Naïve to testosterone replacement, clomiphene, compounded or over-the-counter androgenic steroid derivatives, and dehydroepiandrosterone (DHEA), including investigational products that may affect the reproductive hormonal system or has not been treated with these compounds in the past 6 months
- Male participants willing to minimize the risk of inducing pregnancy for the duration of the clinical study and follow-up period
- Participant must be 18 to 80 years of age inclusive, at the time of signing the informed consent
- Body mass index (BMI) < 35 kilograms per metre square (kg/m^2)
- Male
Exclusion Criteria
- Uncontrolled systemic disease or clinically significant disease, in particular, liver, kidney or heart disease, including hypertension, congestive heart failure, coronary heart disease, chronic atrial fibrillation, sleep apnea or psychiatric illness, that in the investigator's opinion, would put the participant at an unacceptable risk with exposure to Androderm®
- History of prostate (current or in the past) or breast cancer
- Had a recent (within 2 years) history of stroke, transient ischemic attack, acute coronary event, venous thrombotic, or thromboembolic event
- History of alcohol or other substance abuse within the previous 2 years
- Known allergy or sensitivity to the study intervention or its components or other testosterone replacement medications
- Participant who works night shifts or who will need to perform strenuous manual labor while wearing the ABPM monitor
Data sourced from ClinicalTrials.gov (NCT04320745). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.