N/A
N=92
Neuroproprioceptive "Facilitation, Inhibition" and Brain Plasticity
Multiple Sclerosis
Bottom Line
View on ClinicalTrials.gov: NCT04355663 ↗Enrolled (actual)
92
Serious AEs
1.1%
Results posted
Jul 2020
Primary outcome: Primary: White Matter Integrity — 0.5023; 0.5168; 0.4747 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Motor program activating therapy (Behavioral); Vojta's reflex locomotion (Behavioral); Functional electric stimulation (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Charles University, Czech Republic
- Primary completion
- May 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY White Matter Integrity |
0.5023; 0.5168; 0.4747 | — |
| SECONDARY Berg Balance Scale, BBS |
49.79; 47.92; 32.76 | — |
| SECONDARY Timed up and go Test, TUG |
10.15; 10.31; 16.88 | — |
| SECONDARY the 12-item Multiple Sclerosis Walking Scale, MSWS - 12 |
61.57; 59.77; 73.94 | — |
| SECONDARY the 29-item Multiple Sclerosis Impact Scale, MSIS -29 |
32.93; 33.38; 43.47 | — |
Summary
This study investigates whether neuroproprioceptive "facilitation, inhibition" physical therapy induces plastic and adaptive processes of the CNS (white matter integrity changes), if they relate to clinical improvement, and whether therapeutic effect differs between different kinds of therapies.
Eligibility Criteria
Inclusion Criteria
- prevailed spastic paraparesis, stable clinical status and treatment in the preceding 3 months determined by neurologist,
- Expanded Disability Status Scale score (EDSS) max. 7.5
Exclusion Criteria
- other neurological disease or conditions disabling movement
Data sourced from ClinicalTrials.gov (NCT04355663). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.