N/A N=137

Beige Fat, Energy, and the Natriuretic Peptide System

Obesity

Bottom Line

View on ClinicalTrials.gov: NCT04357964 ↗

Enrolled (actual)

137

Serious AEs

0.0%

Results posted

Aug 2024

Primary outcome: Primary: Adipose Tissue Gene Expression of UCP1 (Uncoupling Protein 1)- Differences by Obesity Status — 7.79; 24.33 fold change — p=<0.01

Study Design & Population

Study type: Observational
Phase: N/A
Interventions: —
Age: Adult · 18+ yrs
Sex: All
Sponsor: VA Office of Research and Development
Primary completion: Oct 2022

Outcome Measures

Outcome	Result	p-value
PRIMARY Adipose Tissue Gene Expression of UCP1 (Uncoupling Protein 1)- Differences by Obesity Status	7.79; 24.33	<0.01 sig
SECONDARY Associations of Adipose Tissue Gene Expression of UCP1 (Uncoupling Protein 1) With Natriuretic Peptide Markers	0.28	<0.01 sig
SECONDARY Adipose Tissue Gene Expression of UCP1 (Uncoupling Protein 1)- Differences by Race	14.7; 20.9	0.52

Summary

Obese individuals experience an increased risk of cardiovascular and metabolic diseases. Evidence from genetic studies indicate that the natriuretic peptide (NP) system may protect against these diseases. NP levels differ by obesity status and race has not been established in humans. Thus, the investigators propose a study in which will quantify adipose tissue gene expression and energy expenditure in states of NP deficiency in humans. The overarching postulate is that obese and black individuals have NP deficiencies that contribute to less beige adipose tissue and lower energy expenditure.

Eligibility Criteria

Inclusion Criteria

Men and women ages 18-55 years
Body Mass Index (BMI) >= 18.5 and = 6.5%
Liver Function Tests (LFTs) elevated >3x upper limit of normal
Estimated Glomerular Filtration Rate (eGFR) <40 ml/min
Currently abnormal thyroid stimulating hormone (TSH)

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Data sourced from ClinicalTrials.gov (NCT04357964). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.