N/A
Completed N=137
Beige Fat, Energy, and the Natriuretic Peptide System
Source: ClinicalTrials.gov NCT04357964 ↗Enrolled (actual)
137
Serious AEs
0.0%
Results posted
Aug 2024
Primary outcomePrimary: Adipose Tissue Gene Expression of UCP1 (Uncoupling Protein 1)- Differences by Obesity Status — 7.79; 24.33 fold change — p=<0.01
Summary
Obese individuals experience an increased risk of cardiovascular and metabolic diseases. Evidence from genetic studies indicate that the natriuretic peptide (NP) system may protect against these diseases. NP levels differ by obesity status and race has not been established in humans. Thus, the investigators propose a study in which will quantify adipose tissue gene expression and energy expenditure in states of NP deficiency in humans. The overarching postulate is that obese and black individuals have NP deficiencies that contribute to less beige adipose tissue and lower energy expenditure.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Adipose Tissue Gene Expression of UCP1 (Uncoupling Protein 1)- Differences by Obesity Status |
7.79; 24.33 | <0.01 sig |
| SECONDARY Associations of Adipose Tissue Gene Expression of UCP1 (Uncoupling Protein 1) With Natriuretic Peptide Markers |
0.28 | <0.01 sig |
| SECONDARY Adipose Tissue Gene Expression of UCP1 (Uncoupling Protein 1)- Differences by Race |
14.7; 20.9 | 0.52 |
Eligibility Criteria
Inclusion Criteria
- Men and women ages 18-55 years
- Body Mass Index (BMI) >= 18.5 and = 6.5%
- Liver Function Tests (LFTs) elevated >3x upper limit of normal
- Estimated Glomerular Filtration Rate (eGFR) <40 ml/min
- Currently abnormal thyroid stimulating hormone (TSH)
Data sourced from ClinicalTrials.gov (NCT04357964). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.